A5080047931- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Parasite Biology and Host Interactions
- Marine Ecology and Invasive Species
- Parasites and Host Interactions
- Vector-Borne Animal Diseases
- Toxin Mechanisms and Immunotoxins
- Pharmaceutical Practices and Patient Outcomes
- Identification and Quantification in Food
- Eosinophilic Disorders and Syndromes
- Biochemical and Molecular Research
- Insect and Pesticide Research
- Dermatological diseases and infestations
- Synthesis and Biological Evaluation
- Vector-borne infectious diseases
- Orthoptera Research and Taxonomy
- Fish Biology and Ecology Studies
- E-Learning and Knowledge Management
- Problem and Project Based Learning
- Cardiovascular Issues in Pregnancy
- Viral Infections and Vectors
- Insect symbiosis and bacterial influences
- Parasitic Infections and Diagnostics
- Insect Pest Control Strategies
- Innovations in Medical Education
Universitat de Barcelona
2015-2024
Departament de Salut
1998-2021
Research Institute of Health Sciences
2016
Universitat de les Illes Balears
2016
Banc de Sang i Teixits
2016
Universitat Autònoma de Barcelona
1998-2013
Vall d'Hebron Institut de Recerca
2013
Universidad de Murcia
2012
Zero to Three
2012
Université de franche-comté
2007
We performed a prospective screening for Trypanosoma cruzi infection in 1350 Latin American pregnant women and their offspring Barcelona, Spain. The rate of seroprevalence was 3.4%, 7.3% the newborns were infected. Routine management programs maternity wards may be warranted.
The extent of cryptic leishmaniasis in blood donors from a Spanish endemic area, (Eivissa Island) was studied using various immunological and parasitological methods. Sera 656 were analysed: 16 (2.4%) positive by ELISA 50 (7.6%) Western blot. Peripheral mononuclear cells (PBMC) buffy coat (BC) samples, analyzed culture nested-PCR. DNA L. infantum amplified 27 (22.1%) 122 PBMC. Parasites isolated 3 (4.5%) 67 BC cultures the strains identified as zymodeme MON-28. No parasites PBMC culture....
Visceral leishmaniasis (VL) caused by Leishmania infantum is a zoonotic disease endemic throughout the Mediterranean basin. The existence of asymptomatic human infection entails risk transmission blood transfusion.The prevalence was studied in 1437 donors from Balearic Islands (Majorca, Formentera, and Minorca) using immunologic (Western blot [WB] delayed-type hypersensitivity [DTH]), parasitologic (culture), molecular (nested polymerase chain reaction [PCR]) methods. In addition, efficiency...
Abstract Background Feline leishmaniosis is a vector-borne parasitic disease caused by Leishmania spp. infection in dogs prevalent the Mediterranean basin, but other animals, such as cats, it could also play role epidemiology of disease. Information on geographical distribution and epidemiological features L. infantum cats scarce, particularly urban stray living regions where canine endemic. As diagnosis can be challenging, combining different serological molecular methods useful approach....
ABSTRACT The problems associated with the drugs currently used to treat leishmaniasis, including resistance, toxicity, and high cost of some formulations, call for urgent identification new therapeutic agents novel modes action. aggregated protein dye YAT2150 has been found be a potent antileishmanial compound, half-maximal inhibitory concentration (IC 50 ) approximately 0.5 µM against promastigote amastigote stages Leishmania infantum . encapsulation in liposomes significantly improved its...
Here we report a documented case of congenital transmission Trypanosoma cruzi from Bolivian mother with chronic Chagas disease living in Spain. The serology and blood nested polymerase chain reaction (PCR) were positive for the mother, amastigote forms observed histopathological study placenta umbilical cord. Direct examination, culture, PCR neonate. At age 8 days, neonate began treatment 5-7.5 mg/kg/day benznidazol, which was continued 60 days. negative to T. 20 days after start remained 4...
Aim: A new paromomycin micellar nanogel based on poloxamer 407 was developed. Materials & methods: In vitro release and ex vivo permeation/retention studies were conducted. tolerance assayed by transepidermal water loss. Ex cytotoxicity RAW VERO cells antileishmanial activity Leishmania promastigotes tested. Results: The particle size 9.19 nm (99% loading efficiency) exhibiting Newtonian behavior at 4°C pseudoplastic 25 40°C. Drug followed a Weibull model the drug remaining in skin 31.652...
Human African trypanosomiasis (HAT), Chagas disease and leishmaniasis, which are caused by the trypanosomatids Trypanosoma brucei, cruzi Leishmania species, among most deadly neglected tropical diseases. The development of drugs that active against several is appealing from a clinical economic viewpoint, seems feasible, as these parasites share metabolic pathways hence might be treatable common drugs. From benzonapthyridine 1, an inhibitor acetylcholinesterase (AChE) for we have found...
Amphotericin B (AmB) is a potent antifungal successfully used intravenously to treat visceral leishmaniasis but depending on the Leishmania infecting species, it not always recommended against cutaneous (CL). To address need for alternative topical treatments of CL, aim this study was elaborate and characterize an AmB gel. The physicochemical properties, stability, rheology in vivo tolerance were assayed. Release permeation studies performed nylon membranes human skin, respectively. Toxicity...
Serum samples collected from 237 dogs in Catalonia (northeastern Spain) were screened by Western blot analysis to detect the presence of antibodies specific different Leishmania infantum polypeptide fractions. Leishmaniasis was confirmed 72 these direct examination and/or culture. Another 165 animals Priorat region studied periodically for 2-8 years between 1987 and 1995, giving a total 565 determinations. A control group 93 nonendemic areas also studied. Sera with leishmaniasis recognized...
Visceral leishmaniasis (VL) is characterized by frequent relapses in HIV-infected patients, even those who receive secondary prophylaxis. The aim of our study was to evaluate the efficacy liposomal amphotericin B (L-AMB) for prophylaxis VL patients. From January 2001 December 2005, 17 HIV with at least one previous episode received L-AMB as VL, were included study. Efficacy measured proportion patients remaining free (non-relapse) different time points. Relapses analysed time-to-relapse...
Leishmaniasis is a parasitic disease prevalent in countries of the Mediterranean area.The potential role Leishmania as aetiological factor for cutaneous granulomatous lesions series patients from Western area was evaluated. The practical usefulness Leishmania-specific polymerase chain reaction (PCR) amplification and immunohistochemical techniques skin biopsy specimens assessed.Twenty-five biopsies diagnosed nonspecific dermatoses were included study. A panel histopathological features...
A Western blot (WB) method using a lysate from Trypanosoma cruzi (Maracay strain) epimastigotes was evaluated. Serum samples 37 patients with confirmed Chagas disease (cohort I), 27 Spanish visceral leishmaniasis caused by Leishmania infantum II), and 28 Colombian cutaneous L. panamensis negative serology for III) were tested. The controls 55 healthy seronegative subjects T. Leishmania; of the region endemic IV), non-endemic area V). homogeneous standard band pattern consisting six antigenic...
Molecular methods have been proposed as an alternative tool for the diagnosis of visceral leishmaniasis (VL), but no data are available regarding use monitoring clinical outcome. A prospective cohort study human immunodeficiency virus-(HIV) and VL-coinfected patients was conducted in a university-affiliated hospital Barcelona, Spain. Leishmania parasite load monitored using real-time polymerase chain reaction (PCR) at baseline every 3 months. Cutoff values PCR were determined receiver...