A5022806186- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Inflammatory Bowel Disease
- Long-Term Effects of COVID-19
- Autoimmune and Inflammatory Disorders
- Microscopic Colitis
- Vaccine Coverage and Hesitancy
- Cardiac Health and Mental Health
- Diabetes Management and Research
- Diabetes and associated disorders
- Influenza Virus Research Studies
- Cardiovascular Health and Disease Prevention
- Animal Virus Infections Studies
- COVID-19 epidemiological studies
- Cerebrovascular and Carotid Artery Diseases
- Retinal Diseases and Treatments
- Viral gastroenteritis research and epidemiology
- Cardiovascular Disease and Adiposity
- Birth, Development, and Health
- Diagnosis and treatment of tuberculosis
- Sex and Gender in Healthcare
- Telemedicine and Telehealth Implementation
- Health Systems, Economic Evaluations, Quality of Life
- Diabetes Treatment and Management
- Peroxisome Proliferator-Activated Receptors
Institut Universitari d'Investigació en Atenció Primària Jordi Gol
2021-2025
Institut Català de la Salut
2021-2025
Fundació CTM Centre Tecnològic
2022-2024
Hospital Clínic de Barcelona
2014-2019
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2015-2019
Hospital Universitari Germans Trias i Pujol
2018-2019
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2017
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2017
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2015
Universitat de Barcelona
2013-2015
Measurement of the component fibrosis in Crohn's disease (CD) may have important therapeutic implications. The aim this study was to characterize Magnetic Resonance Imaging (MRI) findings that are differentially associated with presence and those inflammatory activity, using pathological analysis surgically resected intestinal lesions as reference standard.MRI studies identical imaging protocol 41 CD patients who underwent elective bowel resection within 4 months before surgery were...
Ex vivo-generated autologous tolerogenic dendritic cells [tolDCs] can restore immune tolerance in experimental colitis. The aim of this study was to determine the safety and tolerability administration tolDCs refractory Crohn's disease [CD] patients. A phase-I, single-centre, sequential-cohorts, dose-range designed. Stable were generated ex vivo from monocytes following a previously developed protocol, administered by sonography-guided intraperitoneal injection. Six sequential refractory-CD...
<h3>Objective</h3> Severe endoscopic lesions (SEL) in patients with colonic Crohn9s disease (CD) have been linked to higher risk of colectomy. The aims this study were reassess the predictive value colonoscopy compared against MRI for requirement resection surgery CD and determine influence current therapeutic options. <h3>Design</h3> In single-centre, observational, prospective, longitudinal study, an established diagnosis suspected activity included. After baseline assessment, including...
<h3>Objective</h3> To evaluate the feasibility and toxicity of autologous haematopoietic stem cell transplantation (HSCT) for treatment refractory Crohn9s disease (CD). <h3>Design</h3> In this prospective study, patients with CD suffering an aggressive course despite medical treatment, impaired quality life in whom surgery was not acceptable option underwent HSCT. Toxicity complications during procedure within first year following were evaluated, along impact introduction supportive measures...
We assessed the duration and baseline determinants of antibody responses to SARS-CoV-2 spike antigens occurrence reinfections in a prospective cohort 173 Spanish primary health care worker patients followed initially for 9 months subsequently up 12.5 after COVID-19 symptoms onset. Seropositivity receptor-binding domain 149-270 days was 92.49% (90.17% IgG, 76.3% IgA, 60.69% IgM). In subset 64 workers who had not yet been vaccinated by April 2021, seropositivity 96.88% (95.31% 82.81% IgA)...
The COVID-19 pandemic has turned the care model of health systems around world upside down, causing abrupt cancellation face-to-face visits and redirection toward telemedicine. Digital transformation boosts information systems-the more robust they are, easier it is to monitor system in a highly complex state allow for agile reliable analysis.The purpose this study was analyze diagnoses from primary distinguish between those that had higher lower variations, relative 2019 2020 periods...
OBJECTIVE To test whether differences in serum concentrations of adiposity-related low-grade inflammatory mediators could help to differentiate patients with latent autoimmune diabetes adults (LADA), classic adult-onset type 1 diabetes, and 2 diabetes. RESEARCH DESIGN AND METHODS This cross-sectional study involved 75 LADA, 67 390 Serum adiponectin, soluble tumor necrosis factor-α receptor (sTNFRII), interleukin-6, hs-CRP, total leukocyte number were measured. evaluate the these markers...
<sec> <title>BACKGROUND</title> Background: Constipation is one of the most common digestive problems in today's society. In Spain, it estimated that this condition affects between 12% and 20% population, being more frequent women, contributing considerably to quality life, increase medical visits high costs for health system. </sec> <title>OBJECTIVE</title> The objectives study are reduce rate constipation laxative use short term with a structured rehabilitation programme consisting...
<title>Abstract</title> Background Vaccine hesitancy (VH) poses a significant challenge to achieving optimal vaccination coverages worldwide. Paediatric healthcare workers (PHCWs) are fundamental in promoting but often lack adequate training address VH. We designed CONFIVAC, an evidence-based program developed using intervention mapping enhance PHCWs' knowledge, self-efficacy, and skills managing VH fostering culture of immunization primary care. This study aimed evaluate its effectiveness....
Immune memory is essential for the effectiveness of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. In current context pandemic, with a diminished vaccine efficacy against emerging variants, it remains crucial to perform long-term studies evaluate durability and quality immune responses. Here, we examined antibody B-cell responses in cohort 113 healthcare workers distinct exposure histories over 3-year period. Previously infected naive participants developed...
Abstract This study evaluated the persistence of IgM, IgA, and IgG to SARS-CoV-2 spike nucleocapsid antigens up 616 days since onset symptoms in a longitudinal cohort 247 primary health care workers from Barcelona, Spain, followed start pandemic. The also assesses factors affecting antibody levels, including comorbidities responses variants concern as well frequency reinfections. Despite gradual significant decline levels with time, seropositivity five combined was always higher than 90%...
Recent studies have shown that retinal neurodegeneration may precede visible vascular changes in diabetic retinopathy (DR). In addition, the relationship of choroidal thickness (CT) with DR stage is not well defined. To assess inner and structural type 1 subjects (T1D), a cross-sectional study was conducted 242 T1D patients 69 age-matched, non-diabetic individuals. The nasal nerve fibre layer (RNFL) lower without (p < 0.001), mild advanced 0.001) compared to control subjects. ganglion...
We aimed to assess food intake and adherence the Mediterranean Diet in patients with T1D compared nondiabetic individuals. This was an observational, multicenter study 262 subjects 254 age- sex-matched subjects. A validated food-frequency questionnaire administered. The alternate Score (aMED) Healthy Eating Index (aHEI) were assessed. clinical variables also collected. analysis of data included comparisons between groups multivariate models. Compared controls, had a higher dairy products (p...
Diabetes mellitus entails increased atherosclerotic burden and medial arterial calcification, but the precise mechanisms are not fully elucidated. We aimed to investigate implication of CD36 in inflammation calcification processes orchestrated by vascular smooth muscle cells (VSMCs) under hyperglycemic atherogenic conditions. examined expression CD36, pro-inflammatory cytokines, endoplasmic reticulum (ER) stress markers, mineralization-regulating enzymes RT-PCR human VSMCs, cultured a medium...
Women with type 2 diabetes mellitus (T2DM) have a 40% excess risk of cardiovascular diseases (CVD) compared to men due the interaction between sex and gender factors in development, risk, outcomes disease. Our aim was assess differences women T2DM management degree control (CVRF). This matched cross-sectional study including 140,906 subjects without previous CVD 39,186 prior obtained from System for Development Research Primary Care (SIDIAP) database. The absolute relative means or...
Abstract The ongoing evolution of SARS-CoV-2, particularly through the emergence new variants, continues to challenge our understanding immune protection. While antibody levels correlate with protection against earlier variants like Alpha and Delta, their relationship Omicron sub-variants remains unclear. To investigate role neutralizing activity in preventing breakthrough infections, we analyzed longitudinal SARS-CoV-2 humoral responses ancestral virus major emerging a well-characterized...
Antibodies to the nucleocapsid (N) antigen are suggested be used monitor infections after COVID-19 vaccination, as first generation subunit vaccines based on spike (S) protein. We multiplex immunoassays simultaneously measure antibody responses different fragments of SARS-CoV-2 S and N antigens for evaluating immunogenicity mRNA-1273 (Spykevax) BNT162b2 (Comirnaty) in 445 health care workers. report a >4-fold increase post-vaccination IgG levels full length (N FL) C-terminus CT) 5.2% 18.0%...
Evaluar el efecto de una intervención terapia ocupacional en usuarios diagnosticados recientemente síndrome del declive, con disminución índice Barthel y/o Lawton último mes y susceptible mejora según criterio clínico. Estudio cuasiexperimental longitudinal no controlado. Intervención pre-post. Centro salud Sant Hipòlit Voltregà. Osona, Barcelona. Pacientes remitidos por profesional enfermería, trabajo social o medicina familia centro diagnóstico reciente declive que pueda beneficiarse...