A5034583515- Thyroid Cancer Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Management and Research
- Diabetes and associated disorders
- Cardiovascular Health and Disease Prevention
- Epigenetics and DNA Methylation
- Cardiovascular Function and Risk Factors
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Lipoproteins and Cardiovascular Health
- RNA modifications and cancer
- Cerebrovascular and Carotid Artery Diseases
- Diet and metabolism studies
- Nutritional Studies and Diet
- Ferroptosis and cancer prognosis
- Cancer-related Molecular Pathways
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Obesity, Physical Activity, Diet
- MicroRNA in disease regulation
- Peroxisome Proliferator-Activated Receptors
- Cardiovascular Disease and Adiposity
- Bioinformatics and Genomic Networks
- Metabolomics and Mass Spectrometry Studies
- Cardiac Imaging and Diagnostics
Washington University in St. Louis
2021-2025
Institut Universitari d'Investigació en Atenció Primària Jordi Gol
2019-2023
Hospital Universitari Arnau de Vilanova
2009-2023
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2016-2022
Hospital de Sant Pau
2019-2022
Instituto de Salud Carlos III
2016-2021
Centro de Investigación Biomédica en Red
2021
Universitat Autònoma de Barcelona
2020
Hospital Universitari Germans Trias i Pujol
2017-2019
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2016-2018
The purpose of this study was to determine the global patterns aberrant DNA methylation in thyroid cancer.We have used arrays determine, for first time, genome-wide promoter status papillary, follicular, medullary, and anaplastic tumors.We identified 262 352 hypermethylated 13 21 hypomethylated genes differentiated papillary follicular tumors, respectively. Interestingly, other tumor types analyzed displayed more (280 393 medullary tumors) than aberrantly (86 131 tumors). Among indentified,...
Therapeutic options for patients with metastatic medullary thyroid carcinoma (MTC) are limited due to lack of effective treatments. Thus, there is a need thoroughly characterize the pathways molecular pathogenesis and identify potential targets therapy in MTC. Since epidermal growth factor receptor (EGFR) seems play crucial role RET activation, key feature MTCs, several promising EGFR/vascular endothelial 2 (VEGFR2)-targeted drugs have been developed, present study was designed investigate...
Thyroid cancer is a heterogeneous disease with several subtypes characterized by cytological, histological and genetic alterations, but the involvement of epigenetics not well understood. Here, we investigated role aberrant DNA methylation in development well-differentiated thyroid tumors. We performed genome-wide profiling largest tumor series reported to date, comprising 83 primary tumors as 8 samples adjacent normal tissue. The epigenetic profiles were closely related only histology also...
OBJECTIVE We sought to examine the presence and severity of brain small vessel disease (SVD) in patients with type 2 diabetes diabetic retinopathy (DR) compared those without DR. RESEARCH DESIGN AND METHODS evaluated 312 previous cardiovascular (men 51%; mean age 57 years; range 40–75 years); 153 (49%) had MRI was performed evaluate (age-related white matter changes scale) lesions (WMLs) lacunes, transcranial Doppler ultrasound used measure Gosling pulsatility index (PI) middle cerebral...
MicroRNA deregulation could be a crucial event in thyroid carcinogenesis. However, current knowledge is based on studies that have used inherently biased methods. Thus, we aimed to define an unbiased way list of deregulated microRNAs well-differentiated cancer order identify diagnostic and prognostic markers. We performed microRNA deep-sequencing study using the largest tumor collection reported date, comprising 127 molecularly characterized tumors with follicular or papillary patterns...
In this study, we evaluated the lipidome alterations caused by type 1 diabetes (T1D) and 2 (T2D), determining lipids significantly associated with overall in both sexes, glycaemic state.
Traditional risk factors cannot accurately predict cardiovascular events (CVE) in type 2 diabetes (T2D). The LIPOCAT study aimed to prospectively evaluate the clinical utility of advanced lipoprotein characteristics and glycoproteins future a large cohort subjects with mellitus From four different Spanish prospective cohorts, total 933 T2D were selected form study. Advanced 1H-Nuclear Magnetic Resonance (1H-NMR) analysis included (Liposcale®) glycoprotein (Glycoscale) profiling. Random...
Patients with Type 1 Diabetes (T1DM) have a higher risk of cardiovascular disease. This study used carotid ultrasound to identify subclinical plaques and Optical Coherence Tomography (OCT) evaluate ophthalmological markers as predictors plaque presence in 242 adults T1DM, employing machine learning models for early assessment. Individuals (N = 67) did not show significant differences retinal nerve fiber layer (RNFL) ganglion cell (GCL) inner plexiform (IPL) complex compared those without...
Cardiovascular (CV) disease due to atherosclerosis is a major cause of morbidity and mortality in adult patients with diabetes, either type 1 or 2 diabetes. The aim the study was assess association frequency burden subclinical carotid atherosclerotic diabetes according presence severity diabetic retinopathy (DR). A cross-sectional conducted 340 (41.5% DR), 304 non-diabetic individuals. All participants were free from previous CV chronic kidney (CKD). B-mode ultrasound imaging performed all...
// Noel P. Fusté 1,4,* , Esmeralda Castelblanco 2,5,* Isidre Felip 2,4,* Maria Santacana 2,5 Rita Fernández-Hernández 1,4 Sònia Gatius Neus Pedraza Judit Pallarés Tània Cemeli Joan Valls 3 Marc Tarres Francisco Ferrezuelo Xavier Dolcet 2,4 Matias-Guiu 2,4,5 and Eloi Garí 1 Department of Cell Cycle, Lleida, Catalonia, Spain 2 Oncological Pathology, Biostatistics Epidemiology Unit the Institut de Recerca Biomèdica Lleida (IRBLLEIDA), 4 Basic Medical Sciences at University 5 Pathology Molecular...
OBJECTIVE To test whether differences in serum concentrations of adiposity-related low-grade inflammatory mediators could help to differentiate patients with latent autoimmune diabetes adults (LADA), classic adult-onset type 1 diabetes, and 2 diabetes. RESEARCH DESIGN AND METHODS This cross-sectional study involved 75 LADA, 67 390 Serum adiponectin, soluble tumor necrosis factor-α receptor (sTNFRII), interleukin-6, hs-CRP, total leukocyte number were measured. evaluate the these markers...
Aim This study’s objective was to assess the risk of severe in-hospital complications patients admitted for COVID-19 and diabetes mellitus (DM). Design a cross-sectional study. Settings We used pseudonymised medical record data provided by six general hospitals from HM Hospitales group in Spain. Outcome measures Multiple logistic regression analyses were identify variables associated with mortality composite or invasive mechanical ventilation (IMV) overall population, stratified presence...
This study aimed to evaluate the predictive value of diabetic retinopathy (DR) and its stages with incidence major cardiovascular events all-cause mortality in type 2 diabetes mellitus (T2DM) persons our large primary healthcare database from Catalonia (Spain). A retrospective cohort pseudo-anonymized routinely collected health data SIDIAP was conducted 2008 2016. We calculated rates [coronary heart disease (CHD), stroke, or both-macrovascular events] for subjects without DR different DR....
Abstract Environmental factors may alter the fetal genome to cause metabolic diseases. It is unknown whether embryonic immune cell programming impacts risk of type 2 diabetes in later life. We demonstrate that transplantation hematopoietic stem cells (HSCs) made vitamin D deficient utero induce D-sufficient mice. Vitamin deficiency epigenetically suppresses Jarid2 expression and activates Mef2 / PGC1a pathway HSCs, which persists recipient bone marrow, resulting adipose macrophage...
Evidence regarding any association of HDL-particle (HDL-P) derangements and HDL-cholesterol content with cardiovascular (CV) death in chronic heart failure (HF) is lacking. To investigate the prognostic value HDL-P size (HDL-Sz) number cholesterol molecules per for CV HF patients. Outpatient patients were enrolled. Baseline number, subfractions HDL-Sz measured using 1H-NMR spectroscopy. The HDL-C/P ratio was calculated as over HDL-P. Endpoint death, non-CV competing event. 422 included...
Individuals with diabetes have remarkably high rates of cardiovascular morbidity and mortality. However, the incremental risk in is heterogeneous has often been related to renal involvement. The purpose this study was analyse prognostic value subclinical atherosclerosis determining incidence first events (CVEs) individuals chronic kidney disease (CKD) compared CKD without diabetes.
Recent studies have shown that retinal neurodegeneration may precede visible vascular changes in diabetic retinopathy (DR). In addition, the relationship of choroidal thickness (CT) with DR stage is not well defined. To assess inner and structural type 1 subjects (T1D), a cross-sectional study was conducted 242 T1D patients 69 age-matched, non-diabetic individuals. The nasal nerve fibre layer (RNFL) lower without (p < 0.001), mild advanced 0.001) compared to control subjects. ganglion...
To investigate the prevalence and risks factors associated with presence of liver fibrosis in subjects nonalcoholic fatty disease (NAFLD) without type 2 diabetes mellitus (T2D).This study was part a population-based conducted Barcelona metropolitan area among aged 18-75 years old. Secondary causes steatosis were excluded. Moderate-to-advanced defined as stiffness measurement (LSM) ≥ 8.0 kPa assessed by transient elastography.Among 930 NAFLD, moderate-to-advanced higher T2D compared those...
Abstract Background Evidence from prospective cardiovascular (CV) outcome trials in type 2 diabetes (T2DM) patients supports the use of sodium–glucose co-transporter-2 inhibitors (SGLT2i) to reduce risk CV events. In this study, we compared several outcomes between new users SGLT2i and other glucose-lowering drugs (oGLDs) Catalonia, Spain. Methods CVD-REAL Catalonia was a retrospective cohort study using real-world data routinely collected 2013 2016. The cohorts oGLDs were matched by...
Abstract Background Subjects with Type 1 diabetes mellitus (T1DM) have an increased incidence of heart failure (HF). Several pathophysiological mechanisms been involved in its development. The aim this study was to analyze the potential contribution advanced lipoprotein profile and plasma glycosylation (GlycA) presence subclinical myocardial dysfunction subjects T1DM. Methods We included from a Danish cohort T1DM ( Thousand & ) either diastolic and/or systolic dysfunction, control group...