A5083979745- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- PI3K/AKT/mTOR signaling in cancer
- Genetic factors in colorectal cancer
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Adrenal and Paraganglionic Tumors
- Uterine Myomas and Treatments
- Cervical Cancer and HPV Research
- Sarcoma Diagnosis and Treatment
- Circular RNAs in diseases
- Retinoids in leukemia and cellular processes
- Epigenetics and DNA Methylation
- Pleural and Pulmonary Diseases
- Extracellular vesicles in disease
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Cutaneous Melanoma Detection and Management
- Estrogen and related hormone effects
- melanin and skin pigmentation
- Lymphoma Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Chromatin Remodeling and Cancer
Hospital Universitari Arnau de Vilanova
2016-2025
Universitat de Lleida
2016-2025
Biomedical Research Institute of Lleida
2016-2025
Centro de Investigación Biomédica en Red de Cáncer
2017-2023
Hospital Arnau de Vilanova
2023
Instituto de Salud Carlos III
2019-2021
Memorial Sloan Kettering Cancer Center
2015
Molecular Oncology (United States)
2015
Hospital Universitario Ramón y Cajal
2015
Synchronous early-stage endometrioid endometrial carcinomas (EECs) and ovarian (EOCs) are associated with a favorable prognosis have been suggested to represent independent primary tumors rather than metastatic disease. We subjected sporadic synchronous EECs/EOCs from five patients whole-exome massively parallel sequencing, which revealed that the EEC EOC of each case displayed strikingly similar repertoires somatic mutations gene copy number alterations. Despite presence restricted or in...
Targeted therapies in endometrial cancer (EC) using kinase inhibitors rarely result complete tumor remission and are frequently challenged by the appearance of refractory cell clones, eventually resulting disease relapse. Dissecting adaptive mechanisms is vital importance to circumvent clinical drug resistance improve efficacy targeted agents EC. Sorafenib an FDA-approved multitarget tyrosine serine/threonine inhibitor currently used treat hepatocellular carcinoma, advanced renal carcinoma...
// Noel P. Fusté 1,4,* , Esmeralda Castelblanco 2,5,* Isidre Felip 2,4,* Maria Santacana 2,5 Rita Fernández-Hernández 1,4 Sònia Gatius Neus Pedraza Judit Pallarés Tània Cemeli Joan Valls 3 Marc Tarres Francisco Ferrezuelo Xavier Dolcet 2,4 Matias-Guiu 2,4,5 and Eloi Garí 1 Department of Cell Cycle, Lleida, Catalonia, Spain 2 Oncological Pathology, Biostatistics Epidemiology Unit the Institut de Recerca Biomèdica Lleida (IRBLLEIDA), 4 Basic Medical Sciences at University 5 Pathology Molecular...
In developed countries, endometrial carcinoma is the most common cancer that affects female genital tract. Endometrial divided into two main histological types, type I or endometrioid and II non-endometrioid, each of which have characteristic, although not exclusive, molecular alterations mutational profiles. Nevertheless, information about implication relevance some these genes in this disease lacking. We sought here to identify new recurrently mutated cancers play a role tumourigenesis...
Abstract Lung cancer is the leading cause of cancer-related deaths among men and women in world, accounting for 25% mortality. Early diagnosis an unmet clinical issue. In this work, we focused to develop a novel approach identify highly sensitive specific biomarkers by investigating use extracellular vesicles (EVs) isolated from pleural lavage, proximal fluid lung patients, as source potential biomarkers. We EVs ultracentrifuge method 25 control fluids 21 lavages patients. Analysis...
Summary PTEN is one of the most frequently mutated tumor suppressor genes in human cancers. The role carcinogenesis has been validated by knockout mouse models. heterozygous mice develop neoplasms multiple organs. Unfortunately, embryonic lethality biallelic excision inhibited study complete deletion development and progression cancer. By crossing conditional with transgenic expressing a tamoxifen-inducible Cre-ERT under control chicken actin promoter, we have generated model that allows...
In some tumors, phosphatase and tensin homolog (PTEN) inactivation may have prognostic importance predictive value for targeted therapies. Immunohistochemistry (IHC) be an effective method to demonstrate PTEN loss. It was claimed that IHC showed poor reproducibility, lack of standardization, variable effects preanalytical factors. this study, we developed optimal protocol IHC, with clone 6H2.1, by checking the relevance analytical variables in normal tissue tumors endometrium, breast,...
Colorectal cancer (CRC) is the third leading cause of cancer-related mortality worldwide. Current systematic methods for diagnosing have inherent limitations so development a minimally-invasive diagnosis, based on identification sensitive biomarkers in liquid biopsies could therefore facilitate screening among population at risk.In this study, we aim to develop novel approach identify highly and specific by investigating use extracellular vesicles (EVs) isolated from peritoneal lavage as...
Endometrial cancer (EC) is the sixth most common in women worldwide and responsible for more than 89,000 deaths every year. Mortality associated with presence of poor prognostic factors at diagnosis, i.e., diagnosis an advanced stage, a high grade and/or aggressive histology. Development novel approaches that would permit us to improve clinical management EC patients unmet need. In this study, we investigate approach identify highly sensitive specific biomarkers using extracellular vesicles...
Analyzing different tumor regions by next generation sequencing allows the assessment of intratumor genetic heterogeneity (ITGH), a phenomenon that has been studied widely in some types but less well explored endometrial carcinoma (EC). In this study, we sought to characterize spatial and temporal 9 ECs using whole-exome sequencing, performing targeted validation 42 primary 30 metastatic samples analyzed. addition, copy number alterations serous carcinomas were assessed comparative genomic...
PTEN is one of the most frequently mutated genes in human cancers. The frequency alterations particularly high endometrial carcinomas. Loss leads to dysregulation cell division, and promotes accumulation cycle complexes such as cyclin D1-CDK4/6, which an important feature tumour phenotype. Cell proteins have been presented key targets treatment pathogenesis cancer, several CDK inhibitors developed a strategy generate new anticancer drugs. Palbociclib (PD-332991) specifically inhibits CDK4/6,...