A5048530861- Liver Disease Diagnosis and Treatment
- Nutritional Studies and Diet
- Obesity, Physical Activity, Diet
- Phytochemicals and Antioxidant Activities
- Health and Lifestyle Studies
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Lipid metabolism and disorders
- Diet, Metabolism, and Disease
- Hormonal Regulation and Hypertension
- Pharmacogenetics and Drug Metabolism
- Consumer Attitudes and Food Labeling
- PI3K/AKT/mTOR signaling in cancer
- Vitamin D Research Studies
- Antioxidant Activity and Oxidative Stress
- Psidium guajava Extracts and Applications
- Botanical Research and Applications
- Drug Transport and Resistance Mechanisms
- Nanocomposite Films for Food Packaging
- Liver physiology and pathology
- Pancreatic function and diabetes
- Pancreatitis Pathology and Treatment
- Nutrition and Health in Aging
- Drug-Induced Hepatotoxicity and Protection
- Erythrocyte Function and Pathophysiology
San Sebastián University
2020-2025
Hospital Universitario San Ignacio
2024
Instituto de Investigación Sanitaria La Fe
2007-2022
Universitat de València
2015-2022
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2010-2022
Universidad de La Frontera
2020
Leitat Technological Center
2019
Universidad de León
2015
CIC bioGUNE
2015
Hospital Universitari i Politècnic La Fe
2012
The effect on the physical, mechanical, and antibacterial properties of films composed alginate-chitosan with incorporation oregano (EOO) or thyme (EOT) essential oils was evaluated. These showed a thickness between 37.7 38.2 µm, no significant differences for oil content. Water vapor permeability decreased from 4.03 (oil-free film) to 1.65 (g/msPa) × 10−9 in 3% EO. Mechanical reflected reduction tensile strength (TS) 73 films) values 34 38 MPa EO, while elongation (E%) increased 4.8%...
Triglyceride accumulation in nonalcoholic fatty liver (NAFL) results from unbalanced lipid metabolism which, the liver, is controlled by several transcription factors. The Foxa subfamily of winged helix/forkhead box (Fox) factors comprises three members which play important roles controlling both and homeostasis through regulation multiple target genes pancreas adipose tissue. In mouse Foxa2 repressed insulin mediates fasting responses. Unlike however, role Foxa1 has not yet been...
The capacity of human hepatic cell-based models to predict hepatotoxicity depends on the functional performance cells. major limitations hepatocytes include scarce availability and rapid loss phenotype. Hepatoma cells are readily available easy handle, but metabolically poor compared with hepatocytes. Recently developed upcyte offer advantage combining many features primary unlimited hepatoma We analyzed phenotype comparatively HepG2 adult characterize their as a differentiated cell model....
Scope Gut microbiota contributes to non‐alcoholic fatty liver disease (NAFLD) pathogenesis by multiple mechanisms not yet completely understood. Novel differential features between germ‐free mice (GFm) transplanted with protective or non‐protective cecal against NAFLD are investigated. Methods and results composition, plasma, fecal bile acids (BAs) mRNAs quantified in GFm recipients from four donor differing severity (control diet, high‐fat diet [HFD]‐responder, HFD‐non‐responder,...
The vitamin D receptor (VDR) must be relevant to liver lipid metabolism because VDR deficient mice are protected from hepatosteatosis. Therefore, our objective was define the role of on overall in human hepatocytes. We developed an adenoviral vector for and performed transcriptomic metabolomic analyses cultured hepatocytes upon activation by (VitD). Twenty percent responsive genes were related metabolism, including MOGAT1, LPGAT1, AGPAT2, DGAT1 (glycerolipid metabolism); CDS1, PCTP, MAT1A...
The indiscriminate use of oral ferrous sulfate (FeSO4) doses induces significant oxidative damage to health. However, carotene-rich foods such as buriti oil can help the endogenous antioxidant defense and still maintain other body functions. This study aimed assess effects intake in iron-overloaded rats by FeSO4 administration. Buriti has β-carotene (787.05 mg/kg), α-tocopherol (689.02 a predominance monounsaturated fatty acids (91.30 g/100 g). Wistar (n = 32) were subdivided into two...
The small heterodimer partner (SHP) (NR0B2) is an atypical nuclear receptor that lacks a DNA-binding domain. It interacts with and inhibits many transcription factors, affecting key metabolic processes, including bile acid, cholesterol, fatty drug metabolism. Our aim was to determine the influence of steatotic drugs nonalcoholic liver disease (NAFLD) on SHP expression investigate potential mechanisms. found be repressed by (valproate, doxycycline, tetracycline, cyclosporin A) in cultured...
The transcription of tissue-specific and inducible genes is usually subject to the dynamic control multiple activators. Dedifferentiated hepatic cell lines lose expression activators many characteristic genes, such as drug-metabolizing cytochrome P450. Here we demonstrate that by combining adenoviral vectors for CCAAT/enhancer-binding protein alpha (C/EBPalpha), hepatocyte nuclear factor 4alpha (HNF4alpha), constitutive androstane receptor, CYP2B6 inducibility CITCO are restored in human...
Dietary fiber has been associated with health benefits, therefore, the availability of validated tools to assess food consumption high-fiber foods would allow quantification intake this functional nutrient, identification risk groups and target populations, development public policies and/or programs aimed at improving population. In study, a short frequency questionnaire (FFQ) was translated into Spanish its content validity determined by group experts, subsequently conduct pilot test...
The vitamin D receptor (VDR) mediates 1,25-dihydroxyvitamin D3 pleiotropic biological actions through transcription regulation of target genes. expression levels this ligand-activated nuclear are regulated by multiple mechanisms both at transcriptional and post-transcriptional levels. Vitamin is the natural VDR activator, but other molecules signaling pathways have also been reported to regulate activity. In study, we identify valproic acid (VPA) short-chain fatty acids (SCFAs) as novel...
Background: The objective is to provide updated data on the intake of total dietary fibre in population residing Chile and identify food sources that contribute most its intake, as well association with different sociodemographic nutritional status-related determinants. Methods: In this descriptive cross-sectional study, a nationwide survey was applied determine using an instrument has been previously validated resident Chile. Results: sample consisted 1761 participants. Dietary 12.8 ± 7.1...
The Berberidaceae family of shrubs has about 20 species present in Chile; however, the Calafate (Berberis microphylla) native to Chilean and Argentinean Patagonia, is most widely distributed. objective this study was compare antioxidant capacity collected at different locations southern Chile, specifically Aysén Magallanes. Methods: 2000 g berries were harvested both regions. fruit lyophilized for subsequent quantification polyphenols, anthocyanins capacity. Results: All parameters evaluated...
BACKGROUND: Polyphenols are a group of compounds distributed in foods plant origin and have been considered as effective protective agents against chronic diseases. To date, there limited data on polyphenol intakes worldwide. OBJECTIVE: The aim the present study was to describe intake polyphenols their subclasses Chile based extracted from National Food Consumption Survey 2010 –2012 (ENCA). METHODS: A total 3658 participants were selected whom information food consumption frequency,...
The PI3K/AKT pathway, negatively regulated by PTEN, plays a paramount role in glucose metabolism regulation due to its activation the insulin receptor signaling pathway. We generated PTEN-KO mouse evaluate systemic effect of overactivation pathway and homeostasis. Our results demonstrate that mice show very low levels fasted state, which poorly respond pyruvate administration. Insulinemia decreased without alterations pancreatic islets. Among possible reasons, we uncover deregulation...
Background: Polyphenols represent a group of bioactive compounds interest for their efficacy in the prevention and treatment some diseases cardiovascular nature. Calafate (Berberis microphylla) is native Chilean fruit, promising due to its high number phenolic compounds, with predominance anthocyanins delphinidin-3-hexoside petunidin-3-hexoside. Methods: Sprague Dawley rats fed high-fat diet (HFD) were supplemented 350 mg/kg freeze-dried calafate 10 weeks. Dietary variables, plasma glucose,...
The World Health Organization (WHO) is urging Latin American countries to prioritize the prevention of chronic noncommunicable diseases. Diet a crucial factor in determining one’s health, and healthy eating recommendations emphasize consumption fish at least twice week due its protein, vitamin, mineral, essential fatty acids, eicosapentaenoic acid (EPA) docosahexaenoic (DHA). This review was designed compare status as source EPA DHA acids some (namely Brazil, Chile, Colombia, Ecuador),...
Abstract Introduction Alterations in lipid metabolism are responsible for atherogenesis and an increased risk of atherosclerotic cardiovascular disease. The triglycerides to high-density lipoprotein cholesterol ratio (TG/HDL-C) is used assess the diseases; however, it has not been evaluated older adults. aim present study evaluate TG/HDL-C elderly patients analyze its correlation discriminatory capacity with factors according data from SABE Colombia survey. Purpose Describe sociodemographic...