A5023101211- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- COVID-19 and healthcare impacts
- Peripheral Artery Disease Management
- Stroke Rehabilitation and Recovery
- Intracerebral and Subarachnoid Hemorrhage Research
- Trauma and Emergency Care Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Inflammatory Bowel Disease
- Diagnosis and treatment of tuberculosis
- Diabetic Foot Ulcer Assessment and Management
- Neurosurgical Procedures and Complications
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Vascular Malformations Diagnosis and Treatment
- Global Cancer Incidence and Screening
- MRI in cancer diagnosis
- Spinal Dysraphism and Malformations
- Diagnosis and Treatment of Venous Diseases
- Vascular Anomalies and Treatments
- Foot and Ankle Surgery
- Respiratory Support and Mechanisms
Indiana Spine Group
2025
Columbia St. Mary's Hospital
2020-2024
Ascension
2021-2024
St. Vincent Carmel Hospital
2024
St. Vincent Hospital
2024
St Vincent Medical Center
2024
St Vincent Hospital
2024
Institut de Virologie
2020-2022
University of Birmingham
2020-2021
NIHR Birmingham Biomedical Research Centre
2021
Persons with lower-extremity peripheral arterial disease (PAD) are often asymptomatic or have leg symptoms other than intermittent claudication (IC).To identify clinical characteristics and functional limitations associated a broad range of identified among patients PAD.Cross-sectional study 460 men women PAD 130 without PAD, who were consecutively, conducted between October 1998 January 2000 at 3 Chicago-area medical centers.Ankle-brachial index score less 0.90; scores from 6-minute walk,...
Trials of the efficacy and safety endovascular thrombectomy in patients with large ischemic strokes have been carried out limited populations. Download a PDF Research Summary. We performed prospective, randomized, open-label, adaptive, international trial involving stroke due to occlusion internal carotid artery or first segment middle cerebral assess within 24 hours after onset. Patients had ischemic-core volume, defined as an Alberta Stroke Program Early Computed Tomography Score 3 5...
Symptomatic intracranial hemorrhage (sICH) is a serious complication of stroke thrombolytic therapy. Many centers have adopted 0.25-mg/kg tenecteplase instead alteplase for thrombolysis based on evidence from randomized comparisons to as well its practical advantages. There been no significant differences in symptomatic reported clinical trials or published case series the 0.25-mg/Kg dose.
BACKGROUND: Enrollment in the Stenting and Aggressive Medical Management for Prevention of stroke Intracranial Stenosis (SAMMPRIS) trial was halted owing to higher-than-expected 30-day rates stenting arm. Improvement periprocedural from angioplasty intracranial atherosclerotic disease (ICAD) requires an understanding mechanisms these events. OBJECTIVE: To identify types after ICAD. METHODS: Patients who experienced a hemorrhagic or ischemic cerebral infarct with temporary signs within 30...
Importance The role of endovascular thrombectomy is uncertain for patients presenting beyond 24 hours the time they were last known well. Objective To evaluate functional and safety outcomes (EVT) vs medical management in with large-vessel occlusion Design, Setting, Participants This retrospective observational cohort study enrolled between July 2012 December 2021 at 17 centers across United States, Spain, Australia, New Zealand. Eligible had occlusions internal carotid artery or middle...
Patients with large ischemic core stroke have poor clinical outcomes and are frequently not considered for interfacility transfer endovascular thrombectomy (EVT).
Objective Perfusion imaging identifies anterior circulation stroke patients who respond favorably to endovascular thrombectomy (ET), but its role in basilar artery occlusion (BAO) is unknown. We hypothesized that BAO with limited regions of severe hypoperfusion (time reach maximum concentration seconds [Tmax] > 10) would have a favorable response ET compared more extensive involved. Methods performed multicenter retrospective cohort study perfusion prior ET. prespecified Critical Area...
This study was undertaken to evaluate functional and safety outcomes for endovascular thrombectomy (EVT) versus medical management (MM) in patients with large vessel occlusion (LVO) mild neurological deficits, stratified by perfusion imaging mismatch.The pooled cohort consisted of National Institutes Health Stroke Scale (NIHSS) < 6 internal carotid artery (ICA), M1, or M2 occlusions from the Extending Time Thrombolysis Emergecy Neurological Deficits - Intra-Arterial (EXTEND-IA) Trial,...
Background: Posterior circulation (PC) large-vessel occlusion (LVO) strokes have significant morbidity and mortality, but patient selection for acute interventions remains understudied. Multiple computed tomography (CT)-based scores exist, including the CT-perfusion-based CAPS score, CT-angiogram(CTA)-based BATMAN PC-CTA scores, CTA source image or non-contrast-CT-based PC-ASPECTS their predictive values long-term outcomes after thrombectomy not been directly compared. Methods: We conducted...
Background: Several semi-quantitative imaging scores exist to assess the extent of ischemic injury in basilar artery occlusions using various computed tomography (CT)-based modalities. Their inter-rater agreement has never been compared. Methods: We conducted a retrospective multicenter cohort study patients with occlusions. Four (PC-ASPECTS, CAPS, BATMAN, and PC-CTA) were assessed by two raters. Inter-rater was compared Cohen’s kappa statistic reliability intraclass correlation coefficient...
To define the association between baseline ankle brachial index (ABI) level and subsequent onset of severe disability.Prospective cohort study.Baltimore community.Eight hundred forty-seven disabled women aged 65 older participating in Women's Health Aging Study.At baseline, participants underwent measurement ABI lower extremity functioning. Measures functioning included patient's report their ability to walk one-quarter a mile, number city blocks walked last week, stair flights climbed...
Computed tomography angiography (CTA) is increasingly used as a screening tool in the investigation of spontaneous intracerebral hemorrhage (ICH). However, CTA carries additional costs and risks, necessitating its judicious use. The authors hypothesized that subsets patients with nontraumatic, nonsubarachnoid ICH are unlikely to benefit from part diagnostic workup particular patient risk factors may be increase yield detection vascular sources.The performed retrospective analysis 1376...
We thank the Editors of JNIS for alerting us in advance to concerns about SELECT2 raised by Jadhav1 and colleagues appreciate opportunity explain rationale study design clarify benefits including perfusion imaging-based selection criteria. are confident that will provide high-level, reliable data regarding safety efficacy endovascular thrombectomy (EVT) large core patients. The choice imaging modality identifying acute ischemic stroke remains an area considerable debate. Magnetic resonance...
Background Previous studies on racial disparity in mechanical thrombectomy (MT) treatment of acute large vessel occlusion stroke lack individual patient data that influence decision-making. We assessed patient-level a US health care system from 2016 to 2020 for disparities MT utilization and eligibility. Methods Results A retrospective study was performed 34 596 patients admitted 43 hospitals January September 2020. Data included age, sex, race, residential zip code median income population...
Cerebral aneurysm rupture is associated with high rates of morbidity and mortality. Detecting aneurysms at risk critical in management decision making. Rupture has traditionally been size-measured as a maximum dimension. However, are morphologically dynamic, characteristic ignored by large prospective studies. Manual measurement challenging fraught error. We used an artificial intelligence (AI) tool to study that ruptured during conservative detect changes size not appreciated manual linear...
Clinical MR systems operating at 3.0 Tesla have the potential to significantly improve spatial resolution due boost in intrinsic signal noise ratio. However, body imaging these field strengths presents a number of technical challenges. We performed prospective pilot study which 10 patients underwent an cholangiopancreatography (MRCP) examination consecutively on 1.5 and (both Philips Intera). An axial half Fourier segmented turbo spin echo (HASTE) sequence coronal thick-slab 2D turbo-spin...
We examined various nonSTAT commercially available coagulation activation markers in an attempt to help diagnose or exclude the often subtle clinical presentations of proximal deep vein thrombosis (PDVT) and pulmonary embolism (PE). Fifty-five patients presenting Emergency Department were completely assessed. Eleven diagnosed with PDVT, six PE, three both PDVT PE. Thrombus precursor protein (TpP) excluded diagnosis 19 35 negative for and/or D-Dimer 15 patients, prothrombin fragment 1.2 17...
<h3>BACKGROUND AND PURPOSE:</h3> The initial angiographic occlusion rate is the strongest predictor of later rebleeding in previously ruptured coil-embolized cerebral aneurysms. Angiographic estimations aneurysmal rates are, however, subjective nature and confounded by methodologic problems. COR has been developed, its superiority experimentally established to overcome bias. purpose this study was assess clinical value as a more objective aneurysm when compared with SOR described Raymond...