Alan Flores
A5048879527- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological Disorders and Treatments
- Atrial Fibrillation Management and Outcomes
- Cerebral Venous Sinus Thrombosis
- Peripheral Artery Disease Management
- Long-Term Effects of COVID-19
- Advanced X-ray and CT Imaging
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Arrhythmias and Treatments
- COVID-19 and healthcare impacts
- Lung Cancer Diagnosis and Treatment
- Trauma and Emergency Care Studies
- MRI in cancer diagnosis
- Cardiac Arrest and Resuscitation
- Blood Pressure and Hypertension Studies
- Radiomics and Machine Learning in Medical Imaging
- Alzheimer's disease research and treatments
- Cardiovascular Health and Risk Factors
- Cardiovascular and Diving-Related Complications
- Obstructive Sleep Apnea Research
- Intracranial Aneurysms: Treatment and Complications
Hospital Universitari Joan XXIII de Tarragona
2020-2025
Institut d'Investigació Sanitària Pere Virgili
2023-2024
Universidade de Caxias do Sul
2024
Universitat Rovira i Virgili
2024
Asociación Mexicana de Psicología y Desarrollo Comunitario
2019-2023
Health and Education Research Management and Epidemiologic Services (United States)
2023
Roche (Spain)
2023
Universidad Nacional de Asunción
2015-2022
Clinical Trial Investigators
2022
Universidad Columbia del Paraguay
2019-2022
Importance ApTOLL is a TLR4 antagonist with proven preclinical neuroprotective effect and safe profile in healthy volunteers. Objective To assess the safety efficacy of combination endovascular treatment (EVT) for patients ischemic stroke. Design, Setting, Participants This phase 1b/2a, double-blind, randomized, placebo-controlled study was conducted at 15 sites Spain France from 2020 to 2022. included aged 18 90 years who had stroke due large vessel occlusion were seen within 6 hours after...
Introduction The efficacy of intracranial rescue stenting (RS) following failed mechanical thrombectomy (MT) in large-vessel occlusion (LVO) stroke remains uncertain. We aimed to evaluate clinical outcomes RS patients with anterior circulation LVO unsuccessful MT. Patients and methods conducted a retrospective analysis using the Stroke Code Registry Catalonia (January 2016–March 2022), prospective, population-based registry including treated at 10 comprehensive centers. compared between who...
Introduction: Stroke is one of the leading causes death in Latin America, a region with countless gaps to be addressed decrease its burden. In 2018, at first American Ministerial Meeting, stroke physician and healthcare manager representatives from 13 countries signed Declaration Gramado priorities improve region, commitment implement all evidence-based strategies for care. The second meeting March 2020 reviewed achievements 2 years discussed new objectives. This paper will review 2-year...
Background: In reperfusion treatment, advanced neuroimaging can be used to indicate treatment or forecasting outcomes, however immediate access is not widely available. This study aims explore the assessment of initial core volume (ICV) measured on NCCT by a machine learning-based algorithm outcomes in overall and according ASPECTS stroke elapsed time. Methods: Consecutive patients who received were studied two stroke-centers (Jan-2021 Dec-2023). On admission, ICV was defined (aICV) an...
Introduction: Tirofiban has shown a potential effect in reducing early neurological deterioration and improving clinical outcomes selected patients with non-embolic stroke. We aim to analyze the of tirofiban versus standard acute therapy on 90-day presumed Methods: Multicentric retrospective cohort study including consecutive AIS presenting within 24h from symptom onset, baseline mRS 0-1, absence cortical symptoms, identifiable vessel occlusion or other imaging features suggestive embolic...
We aim to assess whether time of day modified the treatment effect in RACECAT trial (Direct Transfer an Endovascular Center Compared Closest Stroke Acute Patients With Suspected Large Vessel Occlusion Trial), a cluster-randomized that did not demonstrate benefit direct transportation thrombectomy-capable center versus nearest local stroke for patients with suspected large vessel triaged nonurban Catalonia between March 2017 and June 2020.We performed post hoc analysis evaluate if association...
COVID-19 pandemic has forced important changes in health care worldwide. Stroke networks have been affected, especially during peak periods. We assessed the impact of and lockdowns stroke admissions Latin America.A multinational study (7 countries, 18 centers) patients admitted outbreak (March-June 2020). Comparisons were made with same period 2019. Numbers cases, etiology severity, acute hospitalization outcomes assessed.Most countries reported mild decreases compared to 2019 (1187 vs....
Mechanical thrombectomy (MT) in ischemic stroke patients with poor prestroke conditions remains controversial. We aimed to analyze the frequency of previously disabled treated MT clinical practice, safety and response preexisting disability, patient characteristics associated a better MT.We studied all consecutive anterior circulation occlusion from January 2017 December 2019 included Codi Ictus Catalunya registry-a government-mandated, prospective, hospital-based data set. Prestroke...
Objetivos. Comparar el proceso asistencial prehospitalario y los resultados hospitalarios de pacientes categorizados como Código Ictus (CI) en función del tipo ambulancia que realiza la primera valoración, analizar factores asociados con un buen resultado funcional mortalidad a 3 meses. Método. Estudio observacional cohortes prospectivo multicéntrico. Incluyó todos CI atendidos por sistema emergencias desde enero 2016 abril 2022. Se recogieron variables prehospitalarias hospitalarias. La...
Background Reports on sex differences in stroke outcome and risk factors are scarce Latin America. Our objective was to analyze clinical prognostic according among participants the LASE (Latin American Stroke Registry). Methods Results Nineteen centers across Central South America compiled data demographics, vascular factors, description, ancillary tests, functional outcomes at short-term follow-up of patients included from January 2012 2017. For present study, all these variables were...
Infection is an independent risk factor for adverse outcome in stroke patients. The of developing infection this setting partly related to a stroke-induced immunodepression, which shift predominant Th2 (immunosuppressive) phenotype has been postulated play major role. Our aim was study whether clinical variables or changes plasma cytokine expression can predict poststroke infections.Medical records 92 patients were reviewed, and the baseline concentration cytokines from Th1/Th2 system...
BACKGROUND: The double-stent retriever (SR) technique has been described as an effective rescue when single-SR fails to induce recanalization. We aimed assess the safety and efficacy of first-line double-SR in patients with stroke undergoing thrombectomy. METHODS: This was a multicenter, randomized, controlled, blinded adjudicated primary outcome study. Patients large vessel occlusion within 24 hours after onset thrombectomy were included. Upon confirmation on initial angiogram, randomly...
<b><i>Background:</i></b> The evolution of the symptomatic intracranial occlusion during transfers from primary stroke centers (PSCs) to comprehensive (CSCs) for endovascular treatment (EVT) is not widely known. Our aim was identify factors related partial or complete recanalization (REC) at CSC arrival in patients with a documented large vessel (LVO) PSC transferred EVT evaluation better define workflow this group patients....
Cardiac Echoscan is the simplified transthoracic echocardiogram focused on main source of emboli detection in acute stroke diagnosis (Stroke Echoscan). We describe clinical impact related to Stroke protocol our Center.Acute patients who underwent by a trained neurologist were included (Echoscan group). All examinations reviewed cardiologists. The embolic etiologies were: ventricular akinesia (VA), severe aortic atheroma (AA) plaque and cardiac shunt (SHUNT). rate median length stay (LOS)...
Background: Acute ischemic stroke patients not referred directly to a comprehensive center (CSC) have reduced access endovascular treatment (EVT). The RACECAT trial is population-based cluster-randomized trial, designed compare mothership and drip-and-ship strategies in acute outside the catchment area of CSC. Aims: To analyze evolution performance indicators regions that participated RACECAT. Methods: This retrospective longitudinal observational study included all alerts evaluated by...
Background Door‐in–door‐out time (DIDO) in nonthrombectomy stroke centers is a key performance indicator acute care. Nonetheless, the relative importance of DIDO on outcome patients transferred for endovascular treatment (EVT) not widely known. Therefore, we aim to explore association between and clinical according onset reperfusion undergoing EVT. Methods Observational multicenter study including thrombectomy‐capable center from local who underwent thrombectomy. The primary was favorable...
Prehospital stroke code activation results in reduced pre- and in-hospital delays triage transport of patients to the right centers. In Paraguay, data about acute reper fusion treatment are not available. Recently, a pilot prehospital program was implemented country November 2016. an observational, single-center cohort study with before–after design, from April 2015 July 2018, we found that 193/832 (23.1%) were activated, these, 54 (6.5%) brought hospital under protocol. Fifty-eight (58...
Introducción: la enfermedad cerebro vascular es causa de discapacidad y muerte en las personas. Se presenta cada vez más población adultos jóvenes.
Importance Double stentretriever (double-SR) is used as a rescue technique when recanalization not achieved in stroke patients undergoing thrombectomy. Double-SR, if applied first-line could increase first-pass rates, known to be associated with better outcomes. Objective To assess the safety and efficacy of double-SR Design Randomized, controlled, blinded adjudicated primary outcome study between 2022 2023. Setting Multicenter (5 sites), national (Spain). Participants Patients ischemic due...
Background Among patients with stroke eligible for endovascular treatment, preprocedure identification of those low chances successful recanalization conventional devices (stent‐retrievers and/or direct aspiration) may allow anticipating procedural rescue strategies. We aimed to develop a preprocedural algorithm able predict failure (RFCD). Methods Observational study. Data from consecutive who received treatment between 2019 and 2022 in 10 centers were collected the Catalan Stroke Registry...