Dolores Cocho
A5023770121- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Atrial Fibrillation Management and Outcomes
- Neurosurgical Procedures and Complications
- Cardiovascular and Diving-Related Complications
- Intracranial Aneurysms: Treatment and Complications
- COVID-19 and healthcare impacts
- Cerebrovascular and genetic disorders
- Long-Term Effects of COVID-19
- Peripheral Artery Disease Management
- Cardiovascular Syncope and Autonomic Disorders
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 Clinical Research Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Neurological diseases and metabolism
- Tracheal and airway disorders
- Dysphagia Assessment and Management
- Blood Coagulation and Thrombosis Mechanisms
- Traumatic Brain Injury Research
- Botulinum Toxin and Related Neurological Disorders
- Peripheral Neuropathies and Disorders
Hospital General de Granollers
2015-2024
Universitat Internacional de Catalunya
2023-2024
Clinical Trial Investigators
2023
Biomedical Research Institute
2016-2019
Universitat Autònoma de Barcelona
2000-2017
Hospital de Sant Pau
2000-2016
Hospital Universitari Germans Trias i Pujol
2005-2016
Hospital Del Mar
2016
Hospital Clínic de Barcelona
2016
Hospital Universitari Arnau de Vilanova
2016
Importance In nonurban areas with limited access to thrombectomy-capable centers, optimal prehospital transport strategies in patients suspected large-vessel occlusion stroke are unknown. Objective To determine whether, areas, direct a center is beneficial compared the closest local center. Design, Setting, and Participants Multicenter, population-based, cluster-randomized trial including 1401 acute attended by emergency medical services where was not capable of performing thrombectomy...
Background and Purpose— Statins may be beneficial for patients with acute ischemic stroke. We tested the hypothesis that pretreated statins at onset of stroke have less severe neurological effects a better outcome. Methods— prospectively included consecutive <24-hour duration. recorded demographic data, vascular risk factors, Oxfordshire Classification, National Institutes Health Stroke Scale (NIHSS) score, admission blood glucose body temperature, cause (Trial Org 10172 in Acute...
Rationale Optimal pre-hospital delivery pathways for acute stroke patients suspected to harbor a large vessel occlusion have not been assessed in randomized trials. Aim To establish whether subjects with rapid arterial evaluation scale based suspicion of evaluated by emergency medical services the field higher rates favorable outcome when transferred directly an endovascular center (endovascular treatment center), as compared standard transfer closest local (local-SC). Design Multicenter,...
Prehospital transfer protocols are based on rapid access to reperfusion therapies for patients with ischemic stroke. The effect of different among receiving a final diagnosis intracerebral hemorrhage (ICH) is unknown.
Whether intravenous thrombolysis adds a further benefit when given before endovascular thrombectomy (EVT) is unknown. Furthermore, delays time to groin puncture, mainly among drip and ship patients.Using region-wide registry data, we selected cases that received direct EVT or combined thrombolysis+EVT for anterior circulation strokes between January 2011 October 2015. Treatment effect was estimated by stratification on propensity score. The average odds ratios the association of treatment...
Despite evidence for the efficacy of thrombolytic therapy in acute ischemic stroke, only 1 to 7% patients receive this therapy. The authors sought determine reasons exclusion from tissue plasminogen activator (tPA) an setting and found avoidable causes 18% patients. Improvements intrahospital coordination would increase number who might benefit tPA treatment at authors' center.
ABSTRACT Background and Purpose. Transesophageal echocardiography (TEE) transcranial Doppler (TCD) are the methods of choice to study patent foramen ovale (PFO), but there discrepancies between 2 concerning PFO detection. No has analyzed right‐to‐left shunt (RLS) quantification concordance. The carried out in different hemodynamic states, Valsalva maneuver (VM) required each also differs. authors compared detection concordance RLS classifications performing studies simultaneously. Methods....
We sought to assess outcomes after endovascular treatment/therapy of acute ischemic stroke, overall and by subgroups, looked for predictors outcome.We used data from a mandatory, population-based registry that includes external monitoring completeness, which assesses reperfusion therapies consecutive patients with stroke since 2011. described subgroups (age ≤ or >80 years; onset-to-groin puncture >6 hours; anterior posterior strokes; previous IV recombinant tissue-type plasminogen activator...
We tested the hypothesis that risk of intracranial hemorrhage (ICH) in patients with cardioembolic ischemic stroke who are treated oral anticoagulants (OAs) can be predicted by evaluating surrogate markers hemorrhagic-prone cerebral angiopathies using a baseline MRI.Patients were participants multicenter and prospective observational study. They older than 64 years, had recent stroke, new users OAs. underwent MRI analysis to evaluate microbleeds, white matter hyperintensities, cortical...
Hospital admission delay is a main limiting factor for effective thrombolytic therapy in stroke patients. We developed code system rapid request of emergency transportation to the hospital and priority availability attending neurologist on patient's arrival at Emergency Department (ED).Over 1-year period, 24-hour telephone hotline between Barcelona public coordination service was established. Priority 1 (P1) defined as patient with symptoms suggestive acute onset less than 3 h, which case...
We evaluated whether stroke severity, functional outcome, and mortality are different in patients with ischemic or without coronavirus disease 2019 (COVID-19) infection.A prospective, observational, multicentre cohort study Catalonia, Spain. Recruitment was consecutive from mid-March to mid-May 2020. Patients had an acute within 48 hours a previous modified Rankin Scale (mRS) score of 0 3. collected demographic data, vascular risk factors, prior mRS score, National Institutes Health Stroke...
Whether the outcome of patients with spontaneous intracerebral hemorrhage (ICH) differs depending on type hospital where they are admitted is uncertain. The objective this study was to determine influence at admission (telestroke center [TSC], primary stroke [PSC], or comprehensive [CSC]) for ICH. We hypothesized that outcomes may be better a CSC.
<b>Objective: </b> To determine whether pretreatment markers of coagulation and fibrinolysis are related to recanalization functional outcome. <b>Methods: The authors included patients treated with IV rt-PA occlusion on baseline transcranial Doppler (Thrombolysis in Brain Ischemia [TIBI] criteria) whom within 6 hours was monitored. At baseline, the recorded data about demographics, vascular risk factors, NIH Stroke Scale (NIHSS) score, early CT signs, etiology, blood glucose, time rt-PA....
Symptomatic intracerebral hemorrhage (ICH) is a major complication of thrombolysis in patients with acute ischemic stroke. We analyzed whether baseline hemostatic markers could predict symptomatic ICH (SICH).In multicenter study treated intravenous tissue plasminogen activator (t-PA) within 3 hours stroke onset, we the following variables: demographic data, vascular risk factors, blood glucose at admission, time from onset symptoms to t-PA infusion, pressure, neurological deficit measured by...
Previous studies have reported differences in the management and outcome of women stroke patients comparison with men. We aim to analyze sex gender medical assistance, access treatment acute Catalonia.Data were obtained from a prospective population-based registry code activations Catalonia (CICAT) January/2016 December/2019. The includes demographic data, severity, subtype, reperfusion therapy, time workflow. Centralized clinical at 90 days was assessed receiving therapy.A total 23,371...
Background Intravenous immunoglobulin (IVIG) and rituximab are considered the first-line second-line treatments for Chronic Ataxic Neuropathy Ophthalmoplegia with IgM-paraprotein, cold Agglutinins, anti-Disialosyl antibodies (CANOMAD), an overall clinical response around 50%. New anti-CD38 daratumumab, targeting long-lived plasma cells, has been reported as a promising therapy treatment-refractory antibody-mediated disorders. We report first case of severe refractory CANOMAD, successfully...
<b><i>Objective:</i></b> To investigate whether data obtained by transcranial Doppler (TCD) have prognostic value in patients with intracerebral hemorrhage (ICH). <b><i>Methods:</i></b> A prospective study of an acute (<12 hours from onset symptoms) spontaneous supratentorial ICH was conducted. Mortality assessed at 30-day follow-up. TCD parameters were both middle cerebral arteries: systolic, diastolic, and mean velocities Pulsatility Index (PI) the affected unaffected hemispheres. The...
The efficacy of thrombolysis in clinical stroke subtypes is unclear. We compared the benefit intravenous rt-PA 11 patients with lacunar syndrome that 33 a non-lacunar syndrome. Patients were matched by NIHSS score and time to treatment. Although no statistically significant differences detected outcome, was greater non- group.
Remote parenchymal hemorrhage (rPH) after intravenous thrombolysis with recombinant tissue-type plasminogen activator may be associated cerebral amyloid angiopathy, although supportive data are limited. We aimed to investigate risk factors of rPH activator.This is an observational study patients ischemic stroke who were treated and included in a multicenter prospective registry. was defined as any extraischemic detected the follow-up computed tomography. collected demographic, clinical,...
Background and Purpose— Vascular recurrence occurs in 11% of patients during the first year after ischemic stroke (IS) or transient attack. Clinical scores do not predict whole vascular risk; therefore, we aimed to find genetic variants associated with that might improve clinical predictive models IS. Methods— We analyzed 256 polymorphisms from 115 candidate genes 3 patient cohorts comprising 4482 IS attack patients. The discovery cohort was prospectively recruited included 1494 patients,...
To determine the frequency and predictors of symptomatic intracerebral hemorrhage (SICH) in patients treated with recombinant tissue plasminogen activator (rt-PA).We reviewed databases 7 tertiary hospitals that ischemic stroke intravenous rt-PA. We recorded demographic data, vascular risk factors, time between onset treatment, dose, NIHSS score, body temperature, blood pressure, platelet count, glucose, antiplatelet CT data. also registered study protocol used for treatment deviations from...
The study aimed to evaluate the impact of a telestroke network on acute stroke care in Catalonia, by measuring thrombolysis rates, access endovascular treatment, and clinical outcome patients population-based study.Telestroke was implemented March 2013 consists 12 community hospitals 1 expert neurologist 24 h/7 day, covering population 1.3 million inhabitants. Rest (6.2 million) Catalonia is covered 8 primary centers (PSC) 6 comprehensive (CSC). After 2-way videoconference visualization...
We aim to assess whether time of day modified the treatment effect in RACECAT trial (Direct Transfer an Endovascular Center Compared Closest Stroke Acute Patients With Suspected Large Vessel Occlusion Trial), a cluster-randomized that did not demonstrate benefit direct transportation thrombectomy-capable center versus nearest local stroke for patients with suspected large vessel triaged nonurban Catalonia between March 2017 and June 2020.We performed post hoc analysis evaluate if association...