A5101642014- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Intracranial Aneurysms: Treatment and Complications
- Cerebral Venous Sinus Thrombosis
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological Disorders and Treatments
- Food Chemistry and Fat Analysis
- Lipoproteins and Cardiovascular Health
- Proteins in Food Systems
- S100 Proteins and Annexins
- Cell Adhesion Molecules Research
- Journalism and Media Studies
- Advanced Statistical Modeling Techniques
- Statistical and numerical algorithms
- Peripheral Artery Disease Management
- Educational Outcomes and Influences
- Cardiovascular Health and Disease Prevention
- Psychological Treatments and Disorders
- Microencapsulation and Drying Processes
- Education and Critical Thinking Development
- Literary and Philosophical Studies
- Statistical Methods and Applications
Hospital Clínic de Barcelona
2016-2025
Health and Education Research Management and Epidemiologic Services (United States)
2023
Universitat de les Illes Balears
2022
Universitat de Barcelona
2015-2021
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2015-2021
Biomedical Research Institute
2017-2021
Universitat Autònoma de Barcelona
2016-2017
Vall d'Hebron Hospital Universitari
2016-2017
Centro de Investigación Biomédica en Red
2017
University of Pittsburgh Medical Center
2017
The purpose of the study is to analyze how coronavirus disease 2019 (COVID-19) pandemic affected acute stroke care in a Comprehensive Stroke Center.On February 28, 2020, contingency plans were implemented at Hospital Clinic Barcelona contain COVID-19 pandemic. Among them, decision refrain from reallocating Team and Unit patients with COVID-19. From March 1 31, we measured number emergency calls Emergency Medical System Catalonia (7.5 million inhabitants), Codes dispatched Barcelona. We...
Background and Purpose— Less than half of acute ischemic stroke patients treated with mechanical thrombectomy obtain permanent clinical benefits. Consequently, there is an urgent need to identify mechanisms implicated in the limited efficacy early reperfusion. We evaluated predictors prognostic significance vessel wall permeability impairment its association blood–cerebrospinal fluid barrier (BCSFB) disruption after thrombectomy. Methods— A prospective cohort stent retrievers was analyzed....
Higher rates of target vessel patency at 24 hours were noted in the thrombectomy group compared with control recent randomized trials. As a prespecified secondary end point, we aimed to assess 24-hour revascularization by treatment groups and occlusion site as they related clinical outcome infarct volume REVASCAT (Randomized Trial Revascularization With Solitaire FR Device Versus Best Medical Therapy Treatment Acute Stroke Due Anterior Circulation Large Vessel Occlusion Presenting Within...
Introduction The efficacy of intracranial rescue stenting (RS) following failed mechanical thrombectomy (MT) in large-vessel occlusion (LVO) stroke remains uncertain. We aimed to evaluate clinical outcomes RS patients with anterior circulation LVO unsuccessful MT. Patients and methods conducted a retrospective analysis using the Stroke Code Registry Catalonia (January 2016–March 2022), prospective, population-based registry including treated at 10 comprehensive centers. compared between who...
<h3>Objective:</h3> To investigate the effect of endovascular treatment on cognitive function as a prespecified secondary analysis REVASCAT (Endovascular Revascularization With Solitaire Device Versus Best Medical Therapy in Anterior Circulation Stroke Within 8 Hours) trial. <h3>Methods:</h3> randomized 206 patients with anterior circulation proximal arterial occlusion stroke to thrombectomy or best medical alone. Patients established dementia were excluded from enrollment. Cognitive was...
Background and Purpose- The clinical course in patients with ischemic stroke treated mechanical thrombectomy (MT) is heterogeneous. We aimed to study the relevance of timing improvement prediction long-term outcome MT. Methods- studied a cohort 423 anterior circulation MT, whom 334 (79.0%) achieved good (modified Rankin Scale score 0-2 at 90-day follow-up). National Institutes Health Stroke scores were assessed before end MT (d0), day 1 (d1), 7 or discharge (d7). explored predictive value...
Computed tomography perfusion (CTP) allows the estimation of pretreatment ischemic core after acute stroke. However, CTP-derived may overestimate final infarct volume. We aimed to evaluate accuracy for prediction volume according time from stroke onset recanalization in 104 patients achieving complete mechanical thrombectomy who had a CTP and 24-h follow-up MRI-DWI. A range thresholds was explored maps at constant increments calculation. Time modified significantly association between DWI...
Endovascular reperfusion therapy is increasingly used for acute ischemic stroke treatment. The occurrence of parenchymal hemorrhage clinically relevant and increases with therapies. Herein we aimed to examine the optimal perfusion CT-derived parameters impact duration brain ischemia prediction after endovascular therapy. A cohort 146 consecutive patients anterior circulation occlusions treated was analyzed. Recanalization assessed at end treatment, rate follow-up neuroimaging. In regression...
Stroke patients with good collateral circulation achieve the best recovery after mechanical thrombectomy (MT) but strict imaging selection may result in untreated that could benefit from MT. We assessed whether extent of collaterals had modifying effects on amount ischemic tissue saved infarction MT over medical treatment (BMT).This was a single center cohort consecutive (n=339) proximal occlusions carotid territory. Patients were categorized according to four point category scale CT...
Abstract Several pretreatment variables such as elevated glucose and hypoperfusion severity are related to brain hemorrhage after endovascular treatment of acute stroke. We evaluated whether severe have synergistic effects in the promotion parenchymal (PH) mechanical thrombectomy (MT). included 258 patients MT-treated who had a computed tomography perfusion (CTP) post-treatment follow-up MRI. Severe was defined regions with cerebral blood volume (CBV) values < 2.5% normal [very-low CBV...
The presence of postinterventional subarachnoid hyperdensities (SA-HD) is a relatively common finding after mechanical thrombectomy (MT). We aimed to assess the incidence, characteristics, clinical relevance, and predictors SA-HD MT as categorized through use dual-energy CT (DE-CT).A single-center consecutive series patients with acute stroke treated was retrospectively reviewed. Posttreatment were defined incident extraaxial in follow-up DE-CT performed within median 8 hours MT. further...
Background Balloon guide catheter (BGC) in stent retriever based thrombectomy (BGC+SR) for patients with large vessel occlusion strokes (LVOS) improves outcomes. It is conceivable that the addition of a bore distal access (DAC) to BGC+SR leads higher efficacy. We aimed investigate whether combined BGC+DAC+SR approach angiographic and clinical outcomes compared alone anterior circulation LVOS. Methods Consecutive LVOS from June 2019 November 2020 were recruited ROSSETTI registry. Demographic,...
<b><i>Background:</i></b> Collateral circulation may modify the effect of neuroprotective therapies. We report a post hoc analysis URICO-ICTUS trial (NCT00860366) assessing modifying treatment pretreatment collaterals on clinical and radiological outcomes in patients with large-vessel acute ischemic stroke receiving uric acid therapy or placebo. <b><i>Methods:</i></b> was randomized where 411 alteplase-treated also received 1,000 mg...
<h3>BACKGROUND AND PURPOSE:</h3> Leukoaraiosis frequently coexists in patients with acute stroke. We studied whether leukoaraiosis could confound the interpretation of CTP findings treated mechanical thrombectomy. <h3>MATERIALS METHODS:</h3> analyzed 236 stroke thrombectomy and CTP, whom 127 (53.8%) achieved complete reperfusion. Periventricular white matter hyperintensities on MR imaging hypodensities NCCT were assessed through Fazekas score. CTP-predicted nonviable tissue was defined as...
The use of artificial neural networks (ANNs) is proposed to optimize the formulation stable oil-in-water emulsions (oil 6% w/w) with a flour made from orange by-products (OBF), rich in pectins (21 g/100 g fresh matter), different concentrations (0.95, 2.38, and 3.40% w/w), combined or without soy proteins (0.3 0.6% w/w). Emulsions containing OBF were against coalescence flocculation (with 2.4 3.4% OBF) creaming (3.4% for 24 h; droplets’ diameter decreased up 44% viscosity increased 37%...