A5052133253- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Neuroblastoma Research and Treatments
- Metabolism and Genetic Disorders
- Cancer-related Molecular Pathways
- Alzheimer's disease research and treatments
- Cancer, Hypoxia, and Metabolism
- Microtubule and mitosis dynamics
- Lung Cancer Research Studies
- Neuroscience and Neuropharmacology Research
- Cardiac Fibrosis and Remodeling
- Adipose Tissue and Metabolism
- Neuroendocrine Tumor Research Advances
- Signaling Pathways in Disease
- Ion channel regulation and function
- Receptor Mechanisms and Signaling
- Metabolism, Diabetes, and Cancer
- Advertising and Communication Studies
- Cancer therapeutics and mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiomyopathy and Myosin Studies
- Nerve injury and regeneration
- Cardiac electrophysiology and arrhythmias
Hospital Sant Joan de Déu Barcelona
2021-2025
Universitat de Barcelona
2013-2024
Hospital de Sant Pau
2023
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2013-2023
Instituto de Salud Carlos III
2012-2023
Institut d'Investigacions Biomèdiques de Barcelona
2023
Institute for Research in Biomedicine
2012-2022
University of Chile
2002-2017
Centro de Investigación Biomédica en Red
2017
Austral University of Chile
2005-2015
Mitochondria are dynamic organelles that play a key role in energy conversion. Optimal mitochondrial function is ensured by quality-control system tightly coupled to fusion and fission. In this connection, mitofusin 2 (Mfn2) participates undergoes repression muscle from obese or type diabetic patients. Here, we provide vivo evidence Mfn2 plays an essential metabolic homeostasis. Liver-specific ablation of mice led numerous abnormalities, characterized glucose intolerance enhanced hepatic...
Increasing evidence indicates that endoplasmic reticulum (ER) stress activates the adaptive unfolded protein response (UPR), but beyond a certain degree of ER damage, this triggers apoptotic pathways. The general mechanisms UPR and its pathways are well characterized. However, metabolic events occur during phase stress, before cell death response, remain unknown. Here, we show that, onset reticular mitochondrial networks redistributed towards perinuclear area their points connection...
Parkinson's disease (PD) is associated with the degeneration of ventral midbrain dopaminergic neurons (vmDAns) and accumulation toxic α-synuclein. A non-cell-autonomous contribution, in particular astrocytes, during PD pathogenesis has been suggested by observational studies, but remains to be experimentally tested. Here, we generated induced pluripotent stem cell-derived astrocytes from familial mutant LRRK2 G2019S patients healthy individuals. Upon co-culture on top control vmDAns...
Mitofusin 2 (Mfn2) plays a major role in mitochondrial fusion and the maintenance of mitochondria-endoplasmic reticulum contact sites. Given that macrophages play inflammation, we studied contribution Mfn2 to activity these cells. Pro-inflammatory stimuli such as lipopolysaccharide (LPS) induced expression. The use Mfn1 myeloid-conditional knockout (KO) mouse models reveals but not is required for adaptation respiration stress conditions production reactive oxygen species (ROS) upon...
A set of different protein kinases have been involved in tau phosphorylations, including glycogen synthase kinase 3β (GSK3β), MARK kinase, MAP the cyclin‐dependent 5 (Cdk5) system and others. The latter include catalytic component Cdk5 regulatory proteins p35, p25 p39. its neuron‐specific activator p35 are essential molecules for neuronal migration laminar configuration cerebral cortex. Recent evidence that Cdk5/p35 complex concentrates at leading edge axonal growth cones, together with...
The ability of a cell to independently regulate nuclear and cytosolic Ca(2+) signaling is currently attributed the differential distribution inositol 1,4,5-trisphosphate receptor channel isoforms in nucleoplasmic versus endoplasmic reticulum. In cardiac myocytes, T-tubules confer necessary compartmentation signals, which allows sarcomere contraction response plasma membrane depolarization, but whether there similar structure tunneling extracellular stimulation control signals locally has not...
There were errors published in J. Cell Sci. 124, 2143-2152.In the section given below, PtdIns(3,4,5)P3 was on four occasions incorrectly printed instead of correct Ins(1,4,5)P3.We apologise for this mistake.Increased mitochondrial Ca2+ drives adaptive metabolic boost observed during early phases ER stressIncreases respiration and ATP production are often consequences increases (Green Wang, 2010). In order to determine whether stress induced by tunicamycin increased Ca2+, we treated cells...
Patients with high-risk neuroblastoma (HR-NB) who are unable to achieve a complete response (CR) induction therapy have worse outcomes. We investigated the combination of humanized anti-GD2 mAb naxitamab (Hu3F8), irinotecan (I), temozolomide (T), and sargramostim (GM-CSF)-HITS-against primary resistant HR-NB. Eligibility criteria included having measurable chemo-resistant disease at end (EOI) treatment. were excluded if they had progressive (PD) during induction. Prior and/or I/T was...
Naxitamab is a humanized anti-disialoganglioside (GD2) monoclonal antibody approved for treatment of bone/bone marrow refractory high-risk neuroblastoma (HR-NB). Compassionate use (CU) expanded access program at Hospital Sant Joan de Deu permitted patients in complete remission (CR). We here report the survival, toxicity, and relapse pattern first or second CR treated with naxitamab sargramostim (GM-CSF).Seventy-three consecutive HR-NB (stage M age >18 months MYCN-amplified stages L1/L2 any...
Glucocorticoids, such as dexamethasone, enhance hepatic energy metabolism and gluconeogenesis partly through changes in mitochondrial function. Mitochondrial function is influenced by the balance between fusion fission events. However, whether glucocorticoids modulate regulation of dynamics currently unknown.Here, we report that effects dexamethasone on hepatoma cells are dependent protein dynamin-related 1 (Drp1). Dexamethasone increased routine oxygen consumption, maximal respiratory...