A5059647775- Environmental Toxicology and Ecotoxicology
- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- NF-κB Signaling Pathways
- Collagen: Extraction and Characterization
- Toxic Organic Pollutants Impact
- Nanoparticles: synthesis and applications
- Pharmaceutical and Antibiotic Environmental Impacts
- Maternal and Perinatal Health Interventions
- Advanced Nanomaterials in Catalysis
- Pregnancy-related medical research
- Gold and Silver Nanoparticles Synthesis and Applications
- Carcinogens and Genotoxicity Assessment
- Mercury impact and mitigation studies
- Birth, Development, and Health
- Heavy metals in environment
- Preterm Birth and Chorioamnionitis
- Insect-Plant Interactions and Control
- Gestational Diabetes Research and Management
- DNA Repair Mechanisms
- Psychedelics and Drug Studies
- Forensic Toxicology and Drug Analysis
- Pelvic floor disorders treatments
- Streptococcal Infections and Treatments
- Pesticide and Herbicide Environmental Studies
Barcelona Biomedical Research Park
2009-2022
Hospital Sant Joan de Déu Barcelona
2001-2020
Institut de Recerca Sant Joan de Déu
2020
Vitenparken
2015
Universitat de Barcelona
1997-2013
Consejo Superior de Investigaciones Científicas
2013
Universitat Politècnica de Catalunya
2008
Fundació Clínic per a la Recerca Biomèdica
1997
Owing to their radical scavenging and UV-filtering properties, ceria nanoparticles (CeO2-NPs) are currently used for various applications, including as catalysts in diesel particulate filters. Because of ability filter UV light, CeO2-NPs have garnered significant interest the medical field and, consequently, poised use applications. The aim this work was investigate effects short-term (24 h) long-term (10 days) CeO2-NP exposure A549, CaCo2 HepG2 cell lines. Cytotoxicity assays tested over a...
Abstract Bacterial resistance to almost all available antibiotics is an important public health issue. A major goal in antimicrobial drug discovery the generation of new chemicals capable killing pathogens with high selectivity, particularly multi-drug-resistant ones. Here we report design, preparation and activity compounds based on a tunable, chemically accessible upscalable lipopeptide scaffold amenable suitable hit-to-lead development. Such could become therapeutic candidates future...
Abstract Textile manufacturing is one of the most polluting industrial sectors because release potentially toxic compounds, such as synthetic dyes, into environment. Depending on class their loss in wastewaters can range from 2% to 50% original dye concentration. Consequently, uncontrolled use dyes negatively affect human health and ecological balance. The present study assessed toxicity textile Direct Black 38 (DB38), Reactive Blue 15 (RB15), Orange 16 (RO16), Vat Green 3 (VG3) using...
Gold nanoparticles (AuNPs) are considered useful vehicles for medical therapy and diagnosis. Despite the progress made in this field, there is need to find direct, reliable, versatile synthetic procedures their preparation as well new multifunctional coating agents. In sense, we have explored use of imidazolium amphiphiles prepare AuNPs designed anion recognition transport. Thus, work describe (a) synthesis, by a phase transfer method, gold using gemini-type surfactants ligands based on...
Bats have been proposed as major reservoirs for diverse emerging infectious viral diseases, with rabies being the best known in Europe. However, studies exploring ecological interaction between lyssaviruses and their natural hosts are scarce. This study completes our active surveillance work on Spanish bat colonies that began 1992. Herein, we analyzed factors might affect infection dynamics observed those colonies. Between 2001 2011, collected tested 2,393 blood samples 45 dead bats from 25...
Safety and toxic effects of nanoparticles are still largely unexplored due to the multiple aspects that influence their behaviour toward biological systems. Here, we focus attention on 12 nm spherical gold nanoparticle coated or not with hyaluronic acid compared its precursor counterpart salt. Results ranging from a 10-days exposure in an vitro model BALB/c 3T3 fibroblast cells show how internalized by endo-lysosomal pathway indirect measurement technique; nanoparticles, though being severe...
Surface-enhanced Raman scattering (SERS) substrates are garnering increasing interest for ultrasensitive high-throughput sensing. Notably, SERS-encoded nanostructures stand out due to their potential nearly unlimited codification with excellent optical properties. In this paper we report a simple, versatile and cost-effective method preparing clusters. These clusters consist of encoded silver nanoparticles assembled onto magnetic microparticles, which externally coated oxide-based...
Mouse infection with intracellular bacteria induces a potent inflammatory response that requires protective mechanisms to avoid infection‐induced immune pathology. CD69 is expressed in all leukocytes during activation after wide range of microbial pathogens. This study explores the way which affects cell Listeria monocytogenes (Lm) and its effects on host protection. We show infectivity bacterial clearance capability are unaltered −/− peritoneal macrophages, bone marrow‐derived macrophages...
The biological activity of two fluorescent Zn(II)–salophen derivatives has been evaluated. In vitro studies (AFM, emission and UV-vis titration with ethidium bromide cell growth inhibition) show different mechanisms interaction DNA. It observed that these compounds enter the cells. Comet assays (with cultured fibroblast cells) have revealed cellular uptake occurs without damaging DNA strands. Preliminary carried out living cells shown IC50 values in a millimolar range, indicative...
Ultra small Gd<sup>3+</sup>/[Fe(CN)<sub>6</sub>]<sup>3−</sup> nanoparticles are investigated <italic>in vivo</italic> as contrast agents for Magnetic Resonance Imaging.
Prussian blue (PB) and its analogues on the nanometric scale are exciting nano-objects that combine advantages of molecular-based materials nanochemistry. Herein, we demonstrate ultra-small PB nanoparticles 2-3 nm can be easily labelled with radioactive (201)Tl(+) to obtain new nanoprobes as radiotracers for 201-thallium-based imaging.
The attention on CeO 2 -NPs environmental and in vivo effects is due to their presence diesel exhaust filters that release a more water-soluble form of ceria NPs, as well use for medical applications. In this work, acute subacute toxicity assays demonstrate no lethal effect these NPs. Anyhow, performing evaluations CD-1 mouse systems, we it even not correct assert NPs are harmless living systems they can induce status inflammation, revealed by hematological-chemical-clinical histological TEM...
TREX2 is a proofreading 3'-5' exonuclease that can be involved in genome maintenance; however, its biological role remains undefined. To better understand the function and physiologic relevance of TREX2, we generated mice deficient by targeted disruption unique coding exon. The knockout are viable do not show relevant differences growth, survival, lymphocyte development, or spontaneous tumor incidence compared with their wild-type counterparts over period up to 2 years. Also, did observe...
The biomedical properties of a porous bio-collagenic polymer extracted from leather industrial waste residues have been investigated in wound healing and tissue regeneration induced wounds rats. Application the pure undiluted bio-collagen to rats dramatically improved its after 7 days terms collagen production filling as well migration differentiation keratinocytes. formulation tested was found be three times more effective than commercial reference product Catrix® (Heal Progress (HP): 8 ±...
<i>Aims:</i> To study the predictive value for preterm delivery of colonization cervix and vagina by <i>ureaplasmas</i> other potentially pathogenic microorganisms. <i>Methods:</i> Prospective analysis a group 200 pregnant women with labor intact membranes, control 50 women. The subjects in both groups were between 24 34 weeks gestation. <i>Ureaplasma </i>spp. <i>Mycoplasma hominis</i> endocervical cultures performed groups....