Tomas Dobrocky
A5074519999- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Neurosurgical Procedures and Complications
- Stroke Rehabilitation and Recovery
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Head and Neck Surgical Oncology
- Intracranial Aneurysms: Treatment and Complications
- Cerebral Venous Sinus Thrombosis
- Spinal Hematomas and Complications
- Cerebrospinal fluid and hydrocephalus
- Peripheral Artery Disease Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Advanced X-ray and CT Imaging
- Vascular Malformations Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Spinal Fractures and Fixation Techniques
- Meningioma and schwannoma management
- Radiation Dose and Imaging
- Medical Imaging Techniques and Applications
- Moyamoya disease diagnosis and treatment
- Medical Imaging and Analysis
- Spine and Intervertebral Disc Pathology
- Neurological Disease Mechanisms and Treatments
University Hospital of Bern
2016-2025
University of Bern
2014-2025
University of Freiburg
2020-2025
United States Nuclear Regulatory Commission
2025
Kaiser Permanente Santa Clara Medical Center
2024
Hospital for Special Surgery
2024
Cornell University
2024
University of Colorado Anschutz Medical Campus
2024
University of California, San Francisco
2024
Mayo Clinic in Florida
2024
Various signs may be observed on brain magnetic resonance imaging (MRI) in patients with spontaneous intracranial hypotension (SIH). However, the lack of a classification system integrating these findings limits decision making clinical practice.To develop probability score based most relevant MRI to assess likelihood an underlying spinal cerebrospinal fluid (CSF) leak SIH.This case-control study consecutive investigated for SIH was conducted at single hospital department from February 2013...
International guidelines recommend avoiding intravenous thrombolysis (IVT) in patients with ischemic stroke who have a recent intake of direct oral anticoagulant (DOAC). To determine the risk symptomatic intracranial hemorrhage (sICH) associated use IVT DOAC ingestion. This international, multicenter, retrospective cohort study included 64 primary and comprehensive centers across Europe, Asia, Australia, New Zealand. Consecutive adult received (both without thrombectomy) were included....
BackgroundEndovascular treatment (EVT) of stroke with large-vessel occlusion is known to be safe and effective. The effect EVT for medium or distal vessels unclear.MethodsWe randomly assigned participants an isolated (occlusion the nondominant codominant M2 segment middle cerebral artery [MCA]; M3 M4 MCA; A1, A2, A3 anterior artery; P1, P2, P3 posterior artery) receive plus best medical alone within 24 hours after participant was last seen well. primary outcome level disability at 90 days,...
Background: There are limited therapeutic options in cases of failed reperfusion (modified thrombolysis cerebral infarction [mTICI] score < 2b) after stent-retriever and/or aspiration based endovascular treatment (EVT) for acute ischemic stroke. Despite the absence data supporting its use, rescue therapy (balloon angioplasty stent implantation) is often utilized such cases. Studies to large vessel occlusions, while outcomes and complications medium/distal occlusions (MDVOs) have not been...
Background and Purpose- Sustained successful reperfusion is an important prognostic factor for good clinical outcome in acute ischemic stroke. We aimed to identify the prevalence, impact, predictors of early reocclusion after initially thrombectomies within a prospective cohort. Methods- A total 711 stroke patients with (modified Thrombolysis Cerebral Infarction, 2b/3) followed magnetic resonance or computed tomographic angiography at 24 48 hours were included. Multivariable logistic...
The benefit of endovascular therapy (EVT) among stroke patients with large ischemic core (ASPECTS 0-5) in the extended time window outside trial settings remains unclear. We analyzed effect EVT these real-world settings.
Background and purpose Thrombus composition has been postulated to affect the success of endovascular therapy. Calcified clots are composed large amounts calcium phosphate which influences their mechanical properties may serve as a model for testing this hypothesis. The aim study was evaluate recanalization complication rates calcified thromboemboli in patients with acute ischemic stroke who underwent thrombectomy. Material methods A retrospective analysis performed all intracranial...
Randomized controlled trials have shown that mechanical thrombectomy (MT) plus best medical treatment improves outcome in stroke patients with large-vessel occlusion the anterior circulation. Whether direct MT is equally effective as bridging thrombolysis (intravenous MT) intravenous eligible remains unclear.We compared clinical and radiological outcomes at 3 months 249 111 receiving for circulation from 2 prospective registries (study period Essen: June 2012 to August 2013, Bern February...
<h3>BACKGROUND AND PURPOSE:</h3> In 5%–10% of patients with acute ischemic stroke an intention to treat mechanical thrombectomy, no reperfusion can be achieved (Thrombolysis in Cerebral Infarction score = 0/1). Purpose this analysis was a systematic assessment underlying reasons for failures. <h3>MATERIALS METHODS:</h3> An intention-to-treat single-center cohort (<i>n</i> 592) re-evaluated all whom could 63). Baseline characteristics were compared between and without After qualitative review...
Achieving complete reperfusion is a key determinant of good outcome in patients treated with mechanical thrombectomy (MT). However, data on treatments geared toward improving after incomplete MT are sparse.
Purpose To propose a modified dynamic CT myelographic technique to locate cerebrospinal fluid (CSF) leaks, also known as cryptogenic in patients with spontaneous intracranial hypotension (SIH) whom previous imaging did not show the dural breach. Materials and Methods This retrospective analysis included 74 consecutive SIH myelographically proven CSF leak who were evaluated between February 2013 October 2017. In 14 patients, myelography prone or lateral position showed exact leakage point...
Spinal cerebrospinal fluid (CSF) leaks cause spontaneous intracranial hypotension (SIH). Microsurgery can sufficiently seal spinal CSF leaks. Yet, some patients suffer from residual symptoms. Aim of the study was to assess predictors for favorable outcome after surgical treatment SIH.We included consecutive with SIH treated surgically January 2013 May 2020. Subjects were surveyed by a questionnaire. Primary resolution symptoms as rated patient. Secondary postoperative headache intensity on...
Very poor outcome despite IV thrombolysis (IVT) and mechanical thrombectomy (MT) occurs in approximately 1 of 4 patients with ischemic stroke is associated a high logistic economic burden. We aimed to develop validate multivariable prognostic model identify futile recanalization therapies (FRTs) undergoing those therapies.Patients from prospectively collected observational registry single academic center treated MT and/or IVT were included. The data set was split into training (N = 1,808,...
Despite evolving treatments, functional recovery in patients with large vessel occlusion stroke remains variable and outcome prediction challenging. Can we improve estimation of interpretable deep learning models using clinical magnetic resonance imaging data?In this observational study, collected data 222 middle cerebral artery M1 segment who received mechanical thrombectomy. In a 5-fold cross validation, evaluated for predicting terms modified Rankin scale at 3 months variables, diffusion...
BACKGROUND: Studies comparing bridging intravenous thrombolysis (IVT) with direct endovascular therapy (EVT) in patients acute ischemic stroke who present late are limited. We aimed to compare the clinical outcomes and safety of IVT due anterior circulation large vessel occlusion underwent EVT 6 24 hours after time last known well. METHODS: enrolled a National Institutes Health Stroke Scale score ≥6 from 20 centers across 10 countries multicenter retrospective CLEAR study (CT for Late...
<h3>Objective</h3> To assess the pathophysiologic changes in patients with spontaneous intracranial hypotension (SIH) based on measures of CSF dynamics, and duration symptoms, a retrospective case-controlled study. <h3>Methods</h3> We included consecutive investigated for SIH at our department from January 2012 to February 2018. leak was considered confirmed if extrathecal contrast spillage seen imaging (CT or MRI) after intrathecal application, dural breach detected by direct intraoperative...