Dinesh Jillella
A5039990217- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Long-Term Effects of COVID-19
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebral Venous Sinus Thrombosis
- Neurological Disorders and Treatments
- Neurological Complications and Syndromes
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Intracerebral and Subarachnoid Hemorrhage Research
- Moyamoya disease diagnosis and treatment
- Neurological and metabolic disorders
- Clinical practice guidelines implementation
- Pharmacological Effects and Toxicity Studies
- Cardiac Imaging and Diagnostics
- Epilepsy research and treatment
- Vitamin D Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Obstructive Sleep Apnea Research
- Cardiac Ischemia and Reperfusion
- Cerebrovascular and genetic disorders
Grady Memorial Hospital
2020-2025
Emory University
2020-2025
Emory Johns Creek Hospital
2024-2025
Emory University Hospital
2020-2024
Boston Medical Center
2022
Boston University
2022
Cleveland Clinic
2019-2022
The Neurological Institute
2020-2022
Emory and Henry College
2021
Universitat Autònoma de Barcelona
2020
Mutations in SCN2A, a gene encoding the voltage-gated sodium channel Nav1.2, have been associated with spectrum of epilepsies and neurodevelopmental disorders. Here, we report phenotypes 71 patients review 130 previously reported patients. We found that (i) encephalopathies infantile/childhood onset (≥3 months age) occur almost as often those an early infantile (<3 months), are thus more frequent than reported; (ii) distinct can be seen within late group, including myoclonic-atonic epilepsy...
Background Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has been associated with a significant risk of thrombotic events in critically ill patients. Aim To summarize the findings multinational observational cohort patients SARS-CoV-2 and cerebrovascular disease. Methods Retrospective consecutive adults evaluated emergency department and/or admitted coronavirus disease 2019 (COVID-19) across 31 hospitals four countries (1 February 2020–16 June 2020). The primary outcome was...
COVID-19 infection has been known to predispose patients both arterial and venous thromboembolic events such as deep thrombosis, pulmonary embolism, myocardial infarction, stroke. A few reports from the literature suggest that Cerebral Venous Sinus Thrombosis (CVSTs) may be a direct complication of COVID-19.
The pandemic caused by the novel coronavirus disease 2019 (COVID-19) has led to an unprecedented paradigm shift in medical care. We sought evaluate whether COVID-19 may have contributed delays acute stroke management at comprehensive centers.Pooled clinical data of consecutive adult patients from 14 US centers (January 1, 2019, July 31, 2020) were queried. rate thrombolysis for nontransferred within Target: Stroke goal 60 minutes was compared between admitted March and (pre-COVID-19), 2020,...
Coronavirus disease 2019 (COVID-19) is associated with a small but clinically significant risk of stroke, the cause which frequently cryptogenic. In large multinational cohort consecutive COVID-19 patients we evaluated clinical predictors cryptogenic short-term functional outcomes and in-hospital mortality among according to stroke etiology.We explored characteristics consecutively 18 years age or older acute ischemic (AIS) laboratory-confirmed from 31 hospitals in 4 countries...
To analyse the clinical characteristics of COVID-19 with acute ischaemic stroke (AIS) and identify factors predicting functional outcome.Multicentre retrospective cohort study patients AIS who presented to 30 centres in USA Canada between 14 March August 2020. The primary endpoint was poor outcome, defined as a modified Rankin Scale (mRS) 5 or 6 at discharge. Secondary endpoints include favourable outcome (mRS ≤2) mortality discharge, ordinal mRS (shift analysis), symptomatic intracranial...
In the setting of Coronavirus Disease 2019 (COVID-19) global pandemic caused by SARS-CoV-2, a potential association this disease with stroke has been suggested. We aimed to describe characteristics patients who were admitted COVID-19 and had an acute ischemic (AIS).This is case series PCR-confirmed academic health system in metropolitan Atlanta, Georgia (USA) between March 24th, 2020 July 17th, 2020. Demographic, clinical, radiographic described.Of 396 during study period, 13 (2.5%) also...
Background: Multiple randomized clinical trials failed to show benefit of anticoagulation over antiplatelets in the secondary prevention for embolic stroke undetermined source (ESUS). However, combination antithrombotic regimens remains unexplored same patient population. Methods: This is a subgroup analysis multicenter retrospective observational cohort consecutive adult patients with ESUS (n=27 sites, 2015-2024). Comparisons were made between treated single (SAPT) or dual antiplatelet...
Introduction: Four randomized clinical trials have not demonstrated the superiority of anticoagulation over antiplatelet therapy in prevention recurrent embolic stroke undetermined source (ESUS). In this multicenter observational cohort study, we evaluated long-term outcomes associated with various antithrombotic strategies according to potential sources. Methods: A retrospective consecutive adult patients ESUS was queried (n=27 sites). Comparisons were made between treated single or...
Background: Nearly one-quarter of ischemic strokes (IS) in the U.S. are recurrent. The purpose this study is to determine risk recurrent IS associated with left ventricular fractional shortening (LVFS), a measure LV dysfunction, patients cryptogenic stroke and atrial cardiopathy enrolled ARCADIA trial. Methods: We performed post-hoc exploratory analysis trial, phase III RCT 1,015 from February 2018 2023. Those ejection fraction <30% were not eligible. dichotomized by LVFS <25%...
Background: Left ventricular (LV) injury is a cardioembolic etiology of ischemic stroke. We aimed to 1) evaluate recurrent stroke risk among patients with cryptogenic and LV injury, 2) determine if there treatment effect anticoagulation in this population. Methods: analyzed the multicenter, retrospective Cardiac Abnormalities Stroke Prevention Recurrence cohort The exposure was defined by ejection fraction (EF) 20-40% and/or wall motion abnormality (hypokinesis or akinesis). primary...
Background: Nearly one-quarter of ischemic strokes (IS) in the U.S. are recurrent. We aimed to determine risk recurrent IS associated with reduced left ventricular ejection fraction (LVEF) patients enrolled ARCADIA trial. Methods: performed a post-hoc exploratory analysis trial, phase III RCT 1,015 cryptogenic stroke atrial cardiopathy from February 2018 2023. Those LVEF <30% were not eligible. dichotomized into <50% and > 50% built adjusted Cox proportional hazard models estimate...
Introduction: Malignancy represents an important subgroup of embolic stroke undetermined source (ESUS). We aim to compare infarct features, potential sources, and long-term outcomes in ESUS patients with without malignancy. Methods: In this pre-specified secondary analysis the Cardiac Abnormalities Stroke Prevention Recurrence (CASPR) retrospective cohort study, active cancers were identified by site investigators adjudicated as malignant if they non-squamous or non-basal cell skin cancers....
Computed tomography perfusion (CTP) has played an important role in patient selection for mechanical thrombectomy (MT) acute ischemic stroke. We aimed to investigate the agreement between parametric maps of 3 software packages - RAPID (RapidAI-IschemaView), Viz CTP(Viz.ai), and e-CTP(Brainomix) estimating baseline core volumes near completely/completely reperfused patients.We retrospectively reviewed a prospectively maintained MT database identify patients with anterior circulation large...
To measure the impact of covid-19 pandemic on admissions to hospital and interventions for acute ischemic stroke myocardial infarction.A retrospective analysis.746 qualifying hospitals in USA from Premier Healthcare Database.Patients aged 18 years older who were admitted with a primary diagnosis or infarction between 1 March 2019 28 February 2021.Relative changes volumes assessed as well intravenous thrombolysis, mechanical thrombectomy, percutaneous coronary intervention (overall only)...
Unprecedented workflow shifts during the coronavirus disease 2019 (COVID-19) pandemic have contributed to delays in acute care delivery, but whether it adversely affected endovascular thrombectomy metrics large vessel occlusion (LVO) is unknown.We performed a retrospective review of observational data from 14 comprehensive stroke centers nine US states with LVO. EVT were compared between March July against 2020 (primary analysis), and state-specific pre-peak peak COVID-19 months (secondary...
Infarct growth rate (IGR) in acute ischemic stroke is highly variable. We sought to evaluate impact of symptom-reperfusion time on outcomes patients undergoing mechanical thrombectomy (MT).
We have demonstrated in a multicenter cohort that the COVID-19 pandemic has led to delay intravenous thrombolysis (IVT) among stroke patients. Whether this contributes meaningful short-term outcome differences these patients warranted further exploration. conducted nested observational study of adult acute ischemic receiving IVT from 9 comprehensive centers across 7 U.S states. Patients admitted prior (1/1/2019–02/29/2020) were compared during early (3/1/2020–7/31/2020). Multivariable...