A5100751037- DNA Repair Mechanisms
- Global Maternal and Child Health
- ECG Monitoring and Analysis
- Uterine Myomas and Treatments
- Antibiotic Resistance in Bacteria
- Cerebrovascular and Carotid Artery Diseases
- Acute Lymphoblastic Leukemia research
- Reproductive Health and Contraception
- Cardiac Arrest and Resuscitation
- Gastric Cancer Management and Outcomes
- Blood disorders and treatments
- RNA and protein synthesis mechanisms
- Liver Disease Diagnosis and Treatment
- Gynecological conditions and treatments
- Prenatal Screening and Diagnostics
- Anesthesia and Neurotoxicity Research
- Pregnancy and preeclampsia studies
- Vitamin D Research Studies
- Endometriosis Research and Treatment
- Neonatal Respiratory Health Research
- DNA and Nucleic Acid Chemistry
- Global Health and Epidemiology
- Adipokines, Inflammation, and Metabolic Diseases
- Telomeres, Telomerase, and Senescence
- Cardiac Ischemia and Reperfusion
Yale University
2022-2025
Institute of Medical Sciences
2021-2025
Queensland Children’s Hospital
2023-2025
The University of Queensland
2025
Bhabha Hospital
2024
St. Jude Children's Research Hospital
2020-2024
Johns Hopkins Hospital
2024
Tanvir Hospital
2023-2024
HCG Cancer Centre
2024
Guru Teg Bahadur Hospital
2015-2023
Abstract Background Posterior fossa syndrome (PFS) is a known consequence of medulloblastoma resection. Our aim was to clinically define PFS, its evolution over time, and ascertain risk factors for development poor recovery. Methods Children with treated at St Jude Children’s Research Hospital from 6/2013 7/2019 received standardized neurological examinations, before periodically after radiation therapy. Most (98.3%) were enrolled on the ongoing multi-institutional protocol (SJMB12; NCT...
Human telomere biology disorders (TBD)/short syndromes (STS) are heterogeneous caused by inherited loss-of-function mutations in telomere-associated genes. Here, we identify 3 germline heterozygous missense variants the RPA1 gene 4 unrelated probands presenting with short telomeres and varying clinical features of TBD/STS, including bone marrow failure, myelodysplastic syndrome, T- B-cell lymphopenia, pulmonary fibrosis, or skin manifestations. All cluster to DNA-binding domain A protein. is...
Introduction: Blood pressure (BP) control after a stroke is crucial in lowering the risk of recurrence. Our prior work found that over 60% patients recently discharged from regional health system with did not achieve BP according to current guidelines. Less known about impact insurance type and co-morbidities on post-stroke control. Objective: To analyze relationship between type, comorbidities among within system. Methods: This report an observational cohort study. Patients were admitted...
Introduction: Cardiomyopathy (CM) can occur in patients hospitalized with acute ischemic stroke (AIS). The epidemiology of AIS and concomitant CM subtypes is not well-described. Methods: Adult hospitalizations the National Inpatient Sample (NIS) from 2018-2020 diagnosis were characterized by etiologies using International Classification Diseases-10 codes. Demographic characteristics clinical outcome rates computed among each subtype. outcomes interest are detailed Table 1. Further...
Background: Nearly one-quarter of ischemic strokes (IS) in the U.S. are recurrent. We aimed to determine risk recurrent IS associated with reduced left ventricular ejection fraction (LVEF) patients enrolled ARCADIA trial. Methods: performed a post-hoc exploratory analysis trial, phase III RCT 1,015 cryptogenic stroke atrial cardiopathy from February 2018 2023. Those LVEF <30% were not eligible. dichotomized into <50% and > 50% built adjusted Cox proportional hazard models estimate...
Introduction: Malignancy represents an important subgroup of embolic stroke undetermined source (ESUS). We aim to compare infarct features, potential sources, and long-term outcomes in ESUS patients with without malignancy. Methods: In this pre-specified secondary analysis the Cardiac Abnormalities Stroke Prevention Recurrence (CASPR) retrospective cohort study, active cancers were identified by site investigators adjudicated as malignant if they non-squamous or non-basal cell skin cancers....
ABSTRACT Introduction: Urinary tract infections make up a major proportion of encountered in outpatient setting hospitals. Treatment is largely based on the epidemiology locally prevalent flora. Selection an appropriate antibiotic crucial, as inappropriate use could contribute to alarming rise antimicrobial resistance. Materials and Methods: This retrospective observational study conducted tertiary care teaching hospital. The urine samples were inoculated cysteine lactose...
To assess the diagnostic accuracy of Spandan Lead II smartphone-based electrocardiogram (ECG) device regarding cardiac arrhythmia, compared with that only lead ECG strip from gold-standard machine (BPL machine) and diagnosis by a cardiologist. The study, conducted August 2, 2022, to June 2023, in local hospital, included 2799 participants aged 20 years above. This was single-blinded, cross-sectional study comparing against Gold Standard diagnosed Participants referred for testing...
Abstract Background Recent large-scale sequencing studies reveal that up to 18% of children with cancer harbor pathogenic variants (PV) in known predisposing genes (CPG). However, many patients exhibit features an underlying predisposition but lack CPG PV. This observation suggests the presence unidentified and/or genes. To address this gap, we interrogated implicated DNA damage repair (DDR) as a source novel signals could account for missing heritability. Methods We examined germline data...
Background & Objectives: Electrocardiography (ECG) stands as a cornerstone diagnostic tool for assessing cardiac health, particularly in ruling out abnormalities. The integration of smartphone devices presents promising avenue expedited detection irregularities. This study aims to evaluate the efficacy ECG subjects admitted Cardiac Care Units (CCUs) and Intensive (CICUs). Methods: A retrospective analysis was conducted on cohort comprising 62 patients presenting with symptoms. Utilizing...
During end stage renal disease (ESRD) inflammatory pathways are activated which may lead to malnutrition inflammation syndrome (MIS). In the present study, 257 ESRD patients and 200 controls were included. Cytokine levels genotyping was done by polymerase chain reaction–restriction fragment length polymorphism enzyme-linked immunosorbent assay (ELISA). Risk estimated through binary logistic regression. Cox proportional hazards regression Kaplan–Meier used for survival analysis. Tumor...
Endogenous endophthalmitis, accounting for between 0.1% and 4% of paediatric endophthalmitis cases, is a rare yet highly destructive infection the eye [1]. Paediatric endogenous has higher incidence in developing countries, such as India, likely due to immunocompromised states secondary nutritional deficiencies [2]. Stenotrophomonas maltophilia (S. maltophilia) an emerging multi-resistant pathogen that can cause generally following trauma, intraocular lens implantation or intravitreal...
BACK GROUND AND OBJECTIVES: Vitamin D receptor (VDR) gene polymorphism is reported to be associated with end-stage renal disease (ESRD). We have investigated the potential role of VDR polymorphisms among ESRD.The influence in 258 ESRD patients comprising 226 (87.5%) male and 32 (12.5%) females was this study. compared 569 healthy controls. The distribution female controls 485 (85.3%) males 84 (14.7%) females. This studied by using polymerase chain reaction (PCR). product digested restriction...
Abstract Cytokines and intercellular adhesion molecule ( ICAM ) play a crucial role in the pathogenesis of primary kidney disease progression to end‐stage renal (ESRD). Cytokine secretion is reported be dependent on single nucleotide polymorphisms located cytokine genes. The different cytokines genes as probable susceptibility factors for ESRD has been explored present study. study was conducted 258 patients ethnically matched 569 controls. Individuals were genotyped interleukin IL ‐6...
The objective of this study is to evaluate the effect Vitamin D3 on symptoms, uterine and leiomyoma volume in women with symptomatic hypovitaminosis D.In pilot, interventional, prospective study, 30 premenopausal concomitant D (<30 ng/ml) received doses 60,000 IU weekly for 8 weeks followed by every 2 another weeks. Change uterine, was evaluated at 16 Serum levels were repeated therapy.A significant negative correlation observed between baseline 25-hydroxy (25(OH) D3) (r = -0.434, P <...