A5046232052- Acute Ischemic Stroke Management
- Infectious Encephalopathies and Encephalitis
- Cerebrovascular and Carotid Artery Diseases
- Innovations in Medical Education
- Infectious Diseases and Tuberculosis
- Bacterial Infections and Vaccines
- Clinical Reasoning and Diagnostic Skills
- Neurosurgical Procedures and Complications
- Cardiovascular Health and Risk Factors
- Parkinson's Disease Mechanisms and Treatments
- Neurological Complications and Syndromes
- Cerebral Venous Sinus Thrombosis
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological disorders and treatments
- Health and Medical Research Impacts
- Machine Learning in Healthcare
- Genetics and Neurodevelopmental Disorders
- Nutritional Studies and Diet
- Sarcoidosis and Beryllium Toxicity Research
- Esophageal and GI Pathology
- Medical Imaging Techniques and Applications
- Syphilis Diagnosis and Treatment
- Genomics and Rare Diseases
- Vascular Malformations Diagnosis and Treatment
- Peripheral Neuropathies and Disorders
University of Michigan
2016-2025
Michigan United
2016-2025
Northwestern University
2017-2023
HealthPartners
2023
Northwestern Memorial Hospital
2022
Outcomes Research Consortium
2017
Background and Purpose: This study aims to determine whether machine learning (ML) natural language processing (NLP) from electronic health records (EHR) improve the prediction of 30-day readmission after stroke. Methods: Among index stroke admissions between 2011 2016 at an academic medical center, we abstracted discrete data EHR on demographics, risk factors, medications, hospital complications, discharge destination unstructured textual clinician notes. Readmission was defined as any...
Introduction: Four randomized clinical trials have not demonstrated the superiority of anticoagulation over antiplatelet therapy in prevention recurrent embolic stroke undetermined source (ESUS). In this multicenter observational cohort study, we evaluated long-term outcomes associated with various antithrombotic strategies according to potential sources. Methods: A retrospective consecutive adult patients ESUS was queried (n=27 sites). Comparisons were made between treated single or...
Background: It is known that there are discrepancies between insurance status and access to care for a variety of health conditions. In addition, differences have been shown in initial in-hospital management stroke as well outcomes the acute setting. We sought examine relationship risk recurrent stroke, major bleeding or death following an incident cryptogenic stroke. Methods: Patients with included multicenter (n=27 sites) retrospective observational cohort complete were evaluated primary...
Background: Left ventricular (LV) injury is a cardioembolic etiology of ischemic stroke. We aimed to 1) evaluate recurrent stroke risk among patients with cryptogenic and LV injury, 2) determine if there treatment effect anticoagulation in this population. Methods: analyzed the multicenter, retrospective Cardiac Abnormalities Stroke Prevention Recurrence cohort The exposure was defined by ejection fraction (EF) 20-40% and/or wall motion abnormality (hypokinesis or akinesis). primary...
Introduction: Malignancy represents an important subgroup of embolic stroke undetermined source (ESUS). We aim to compare infarct features, potential sources, and long-term outcomes in ESUS patients with without malignancy. Methods: In this pre-specified secondary analysis the Cardiac Abnormalities Stroke Prevention Recurrence (CASPR) retrospective cohort study, active cancers were identified by site investigators adjudicated as malignant if they non-squamous or non-basal cell skin cancers....
Strokes involving the artery of Percheron (AOP), an anatomic variant thalamic vascular supply, are rare. Little is known about inpatient hospital course for these patients. We retrospectively identified consecutive patients with AOP in their medical charts from a university-based tertiary care January 1, 2000, to August 15, 2017. A chart review demographics, transfer status, in-hospital versus community onset stroke, emergency services (EMS) use, presenting signs/symptoms, time radiologic...
Cytotoxic lesions of the corpus callosum (CLOCCs) have broad differential diagnoses. Differentiating these from vascular etiology is high clinical significance. We compared and radiological characteristics outcomes between splenial CLOCCs in a retrospective cohort study. examined radiologic 155 patients with diffusion restriction splenium callosum. Patients attributed to (N = 124) were older (64.1 vs. 34.6 years old, p < 0.001) had >1 risk factor (91.1% 45.2%, 0.001), higher LDL A1c...
Diffusion-restricted (DR) lesions of the splenium are encountered in a wide variety pathologies, and their significance is often unclear. We sought to report spectrum clinical presentations, neuroimaging patterns, predictors radiographic outcomes from DR splenial lesions.
Introduction: In 2014, the Eighth Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC8) included race-specific recommendations for antihypertensive treatments (e.g. calcium channel blockers [CCBs] Black persons). The impact these guidelines anti-hypertensive regimen changes over time, if this varied by prevalent stroke status, is unclear. Methods: REGARDS participants reporting medications with without history who completed an in-home...
Recent hypertension guidelines for the general population have included race-specific recommendations antihypertensives, whereas current stroke-specific antihypertensives do not vary by race. The impact of these on antihypertensive regimen changes over time, and if this has varied prevalent stroke status, is unclear. use medications was studied cross-sectionally among self-identified Black White participants, aged ≥45 years, with without history stroke, from REGARDS study (Reasons Geographic...
Burnout has become an increasingly recognized problem in higher medical education and is particularly prevalent within the field of Neurology its training programs. Many previously reported wellness initiatives other residencies focused mainly on community/team building. We developed a comprehensive Wellness Curriculum (WC) established new role Resident Liaison order to facilitate across department program. Here we present 6-step outline our WC which can easily be adapted needs The steps...
Objective: To explore the role of elevated blood pressure as a risk factor for motor decline in Parkinson disease (PD). Background: Microvascular brain pathology occurs aging, where it associates with subclinical impairments. We have previously reported that white matter hyperintensities (WMHs) correlate more rapid rate feature accrual PD. Advanced age and higher systolic are two key factors development WMHs may influence progressive burden Design/Methods: Using data from multicenter CALM-PD...
A 77-year-old-man presents with chorea, parasomnias, dysarthria and dysphagia, cognitive issues. broad workup reveals positive anti-IgLON5 antibody. This case report represents a textbook example of syndrome.
An 18-year-old man with C6 quadriparesis presented two 30-minute episodes of thunderclap headache, vision loss, new urinary incontinence, hypertension (200s/90s), and bradycardia more than 24 hours. Imaging demonstrated multifocal cerebrovascular narrowing (Figure 1), restricted diffusion, hyperintense T2/FLAIR signal 2); transcranial Dopplers (TCDs) displayed increased velocities. Reversible cerebral vasoconstriction syndrome (RCVS) was diagnosed.
Introduction: Diffusion restriction within the splenium of corpus callosum poses a clinical challenge. Whereas cytotoxic lesions (CLOCC) have broad differential diagnoses and often favorable prognosis, vascular splenial may require acute stroke evaluation initiation secondary prevention. Differentiating these is significance; however, no prior studies compared them. We sought to compare radiological characteristics outcomes between CLOCCs. Methods: This was retrospective cohort study using...
Objective: Tumor Necrosis Factor-α inhibitors (TNF-α) such as infliximab are increasingly being utilized for the management of neurosarcoidosis. Although there is growing evidence efficacy CNS involvement, adverse consequences this patient population not well-described. We report first case infliximab-induced demyelinating polyneuropathy (D-PN) in a with Background: A 55-year-old African-American woman multi-systemic sarcoidosis including history diffuse leptomeningeal involvement presented...