A5037062313- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Vascular Malformations Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Acute Ischemic Stroke Management
- Meningioma and schwannoma management
- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrospinal fluid and hydrocephalus
- Moyamoya disease diagnosis and treatment
- Management of metastatic bone disease
- Venous Thromboembolism Diagnosis and Management
- Vascular Procedures and Complications
- Spinal Hematomas and Complications
- Spine and Intervertebral Disc Pathology
- Aortic aneurysm repair treatments
- Spinal Fractures and Fixation Techniques
- Cerebral Venous Sinus Thrombosis
- Stroke Rehabilitation and Recovery
- Antiplatelet Therapy and Cardiovascular Diseases
- Spinal Dysraphism and Malformations
- CAR-T cell therapy research
- Virus-based gene therapy research
Orlando Health
2019-2025
TESLA (Czechia)
2024
Neuroscience Institute
2022
Brigham and Women's Hospital
2022
University of Alabama at Birmingham
2013-2021
Harvard University
2017-2020
Geisinger Medical Center
2019-2020
Beth Israel Deaconess Medical Center
2017-2020
Geisinger Health System
2019
University of Toronto
2019
M032 is a second-generation oncolytic herpes simplex virus (oHSV) that selectively replicates in tumor cells. kills cells directly through replication and then proceeds to infect proximity, continuing the process of destruction. In addition this direct activity, carries therapeutic payload—thus acting as gene therapy vector—and causes cell synthesize secrete immunity-stimulating protein interleukin-12 (IL-12) before death.1 Human IL-12 expressed promotes an immune response against surviving...
Thromboembolic complications constitute a significant source of morbidity after neurointerventional procedures. Flow diversion using the pipeline embolization device for treatment intracranial aneurysms necessitates use dual antiplatelet therapy to reduce this risk. The platelet function testing before placement remains controversial.A retrospective review prospectively maintained databases at 3 academic institutions was performed from years 2009 2016 identify patients with treated...
Abstract Background Radiographic leptomeningeal disease (LMD) develops in up to 30% of patients following postoperative stereotactic radiosurgery (SRS) for brain metastases. However, the clinical relevancy this finding and outcomes after various salvage treatments are not known. Methods Patients with metastases, which 1 was resected treated adjunctive SRS, who subsequently developed LMD were combined from 7 tertiary care centers. pattern categorized as nodular (nLMD) or classical...
OBJECTIVE Flow diversion for posterior circulation aneurysms performed using the Pipeline embolization device (PED) constitutes an increasingly common off-label use otherwise untreatable aneurysms. The safety and efficacy of this treatment modality has not been assessed in a multicenter study. METHODS A retrospective review prospectively maintained databases at 8 academic institutions was years 2009 to 2016 identify patients with treated PED placement. RESULTS total 129 consecutive underwent...
Postresection hydrocephalus is observed in approximately 30% of pediatric patients with posterior fossa tumors. However, which will develop postresection not known. The Canadian Preoperative Prediction Rule for Hydrocephalus (CPPRH) was developed an attempt to identify this subset patients, allowing the optimization their care. authors sought validate and critically appraise CPPRH.
Abstract BACKGROUND: To date, the use of flow-diverting Pipeline Embolization Device (PED) for small intracranial aneurysms (≤ 7 mm) has been reported only in single-center series. OBJECTIVE: evaluate safety and efficacy PED a multicenter cohort. METHODS: Five major academic institutions United States provided data on patient demographics, aneurysm features, treatment characteristics consecutive patients with ≤ mm treated between 2009 2015. Radiographic outcome was assessed digital...
<h3>BACKGROUND AND PURPOSE:</h3> Flow diversion with the Pipeline Embolization Device (PED) for treatment of intracranial aneurysms is associated a high rate aneurysm occlusion. However, clinical and radiographic predictors incomplete occlusion are poorly defined. In this study, at last angiographic follow-up after PED were assessed. <h3>MATERIALS METHODS:</h3> A retrospective analysis consecutive treated between 2009 2016, 3 academic institutions in United States, was performed. Cases...
Background The Woven EndoBridge (WEB) device is frequently used for the treatment of intracranial aneurysms. Postoperative management, including use aspirin, varies among clinicians and institutions, but its impact on outcomes WEB has not been thoroughly investigated. Methods This was a retrospective, multicenter study involving 30 academic institutions in North America, South Europe. Data from 1492 patients treated with were included. Patients categorized into two groups based their...
OBJECTIVE Contemporary treatment for paraophthalmic artery aneurysms includes flow diversion utilizing the Pipeline Embolization Device (PED). Little is known, however, about potential implications of anatomical relationship ophthalmic (OA) origin and aneurysm, especially in smaller aneurysms. METHODS Four major academic institutions United States provided data on small (≤ 7 mm) that were treated with PED between 2009 2015. The OA radiographic outcomes aneurysm occlusion, patency assessed...
OBJECTIVE The Pipeline embolization device (PED) is a routine choice for the endovascular treatment of select intracranial aneurysms. Its success based on high rates aneurysm occlusion, followed by near-zero recanalization probability once occlusion has occurred. Therefore, identification patient factors predictive incomplete last angiographic follow-up critical to its success. METHODS A multicenter retrospective cohort analysis was conducted consecutive patients treated with PED unruptured...
<h3>BACKGROUND AND PURPOSE:</h3> Flow diversion with the Pipeline Embolization Device is increasingly used for endovascular treatment of intracranial aneurysms due to high reported obliteration rates and low associated morbidity. While covered branches in anterior circulation generally asymptomatic, this has not been studied within posterior circulation. The aim study was evaluate association between branch coverage occlusion, as well ischemic events a cohort patients treated Device....
Mechanical thrombectomy is the established treatment for acute ischemic stroke due to large vessel occlusion (LVO). The authors sought identify early predictors of a favorable outcome in patients treated with mechanical thrombectomy.