A5071144602- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Intracranial Aneurysms: Treatment and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Stroke Rehabilitation and Recovery
- Blood Coagulation and Thrombosis Mechanisms
- Meningioma and schwannoma management
- Neurosurgical Procedures and Complications
- Neurofibromatosis and Schwannoma Cases
- Vascular Malformations Diagnosis and Treatment
- Vascular Malformations and Hemangiomas
- Glioma Diagnosis and Treatment
- Peripheral Artery Disease Management
- Pituitary Gland Disorders and Treatments
- Spinal Fractures and Fixation Techniques
- Advanced X-ray and CT Imaging
- Head and Neck Surgical Oncology
- Machine Learning in Healthcare
- Vascular Procedures and Complications
- Vascular Tumors and Angiosarcomas
- Dysphagia Assessment and Management
- Clinical practice guidelines implementation
- Migraine and Headache Studies
University Medical Center Hamburg-Eppendorf
2020-2025
Stadtspital Waid
2023-2025
Eppendorf (Germany)
2025
Baylor School
2025
University Hospital of Basel
2020-2024
Universität Hamburg
2020-2024
Heidelberg University
2020-2024
University Hospital Heidelberg
2020-2024
Hospital Base
2024
Triemli Hospital
2024
The introduction of stent retrievers allows for a complete extraction and histological analysis human thrombi. Ischemic stroke is major health issue, differentiation underlying causes highly relevant to prevent recurrent stroke. Therefore, histopathologic the embolic clots after removal may provide valuable information about pathologies. This study analyzes clot composition aims identify specific patterns that might help distinguish ischemic stroke.Patients with occlusion carotid-T or middle...
The impact of endovascular vessel recanalization on patients with a low initial Alberta Stroke Program Early Computer Tomography Score (ASPECTS) is still uncertain. We hypothesized that leads to an improvement in mortality and degree disability by reducing brain oedema malignant mass effect. In this multicentre observational study, acute ischaemic stroke due large occlusion the anterior circulation ASPECTS ≤ 5 were analysed. Patients assembled into two groups: successful (thrombolysis...
Clinical evidence of the potential treatment benefit mechanical thrombectomy for posterior circulation distal, medium vessel occlusion (DMVO) is sparse.To investigate frequency as well clinical and safety outcomes isolated DMVO stroke to compare them with standard medical or without intravenous thrombolysis (IVT) in daily practice.This multicenter case-control study analyzed patients who were treated primary distal cerebral artery (PCA) P2 P3 segment. These received (with IVT) at 1 23...
For patients with symptomatic acute occlusions of the internal carotid artery below circle Willis, endovascular and best medical treatment were both effective safe therapeutic options.
<h3>Importance</h3> Randomized clinical trials have shown the efficacy of thrombectomy large intracranial vessel occlusions in adults; however, any association therapy with outcomes children is unknown. <h3>Objective</h3> To evaluate use endovascular recanalization pediatric patients arterial ischemic stroke. <h3>Design, Setting, and Participants</h3> This retrospective, multicenter cohort study, conducted from January 1, 2000, to December 31, 2018, analyzed databases 27 stroke centers...
The introduction of stent retrievers has made the complete extraction and histological analysis human thrombi possible. A number large randomized trials have proven efficacy thrombectomy for ischemic stroke; however, thrombus composition could an impact on risk intervention. We therefore investigated histologic features interventional outcome procedure-related embolisms. For a pre-interventional estimation parameters, we assessed CT attenuation thrombi.We prospectively included all...
The aim of the present European Stroke Organisation guideline is to provide clinically useful evidence-based recommendations on management patients with intracranial atherosclerotic disease (ICAD). guidelines were prepared following Standard Operational Procedure and according GRADE methodology. ICAD represents a major cause ischemic stroke worldwide, affected by this condition are exposed high risk for future strokes other cardiovascular events, despite best medical therapy available. We...
Background Evidence supporting a potential benefit of thrombectomy for distal medium vessel occlusions (DMVOs) the anterior cerebral artery (ACA) is, to knowledge authors, unknown. Purpose To compare clinical and safety outcomes between mechanical (MT) best medical treatment (BMT) with or without intravenous thrombolysis primary isolated ACA DMVOs. Materials Methods Treatment Primary Medium Vessel Occlusion Stroke, TOPMOST, is an international, retrospective, multicenter, observational...
Significant early hematoma growth in patients with intracerebral hemorrhage is an independent predictor of poor functional outcome. Recently, the novel blend sign (BS) has been introduced as a new imaging for predicting noncontrast computed tomography. Another parameter increasing size well-established spot (SS) visible tomographic angiography. We, therefore, aimed to clarify association between established SS and BS their values secondary neurological deterioration.Retrospective study...
Blend sign (BS) and black hole (BHS) on non-contrast computed tomography (NCCT) spot (SS) CT-angiography (CTA) are indicators of early hematoma expansion in spontaneous intracerebral hemorrhage (ICH). However, their independent contributions to outcome have not been well explored.In this retrospective study, inclusion criteria were: 1) ICH 2) NCCT CTA performed admission within 6 hours after onset symptoms. Discharge was dichotomized as good (modified Rankin Scale [mRS] 0-3) poor (mRS 4-6)...
Identification of risk factors for perioperative epilepsy remains crucial in the care patients with meningioma. Moreover, associations brain invasion clinical and radiological variables have been largely unexplored. The authors hypothesized that cortex subsequent increased edema facilitate seizures, they compared data seizures brain-invasive or noninvasive
Background and Purpose: Intracranial hemorrhage (ICH) remains a major complication of endovascular treatment (ET) in acute stroke. The aim this study was to identify clinical imaging predictors for ICH patients with ischemic stroke undergoing successful ET. Methods: We performed retrospective analysis large vessel occlusion the anterior circulation who underwent ET at our university medical center between 2015 2018. diagnosed on non-enhanced CT binary outcome defined: occurrence immediate...
Studies evaluating the effect of reperfusion on ischemic edema in acute stroke described conflicting results. Net water uptake (NWU) per brain volume is a new quantitative imaging biomarker space-occupying edema, which can be measured computed tomography (CT). We sought to investigate effects vessel recanalization formation using NWU. In this multicenter observational study, patients with large occlusion (LVO) anterior circulation were consecutively screened. Patients (thrombolysis cerebral...
Abstract We hypothesized that imaging-only-based machine learning algorithms can analyze non-enhanced CT scans of patients with acute intracerebral hemorrhage (ICH). This retrospective multicenter cohort study analyzed 520 and clinical data spontaneous ICH. Clinical outcome at hospital discharge was dichotomized into good poor using different modified Rankin Scale (mRS) cut-off values. Predictive performance a random forest approach based on filter- texture-derived high-end image features...
Intracranial hemorrhage has been observed in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (COVID-19), but the clinical, imaging, and pathophysiological features of intracranial bleeding during COVID-19 remain poorly characterized. This study describes clinical imaging characteristics who presented a European multicenter cohort.
This study evaluates the benefit of endovascular treatment (EVT) for patients with extensive baseline stroke compared best medical treatment.This retrospective, multicenter compares EVT and computed tomography (CT)–based selection infarcts (Alberta Stroke Program Early CT Score ≤5) attributed to anterior circulation stroke. Patients were selected from German Registry 3 tertiary centers. Primary functional end points rates good (modified Rankin Scale score ≤3) very poor outcome ≥5) at 90...
In the evaluation of oropharyngeal dysphagia, instrumental procedures, for example, flexible endoscopic swallowing or videofluoroscopic study, are essential to improve diagnostic accuracy salient findings such as penetration, aspiration, pharyngeal residue. To date, it is unclear which 2 methods represents gold standard. The aim this therefore, was compare videofluoroscopy and endoscopy during a simultaneous examination in large cohort patients with dysphagia.Prospective observational...
We assessed the efficacy and safety of mechanical thrombectomy (MT) in adult stroke patients with anterior circulation large vessel occlusion presenting late time window not fulfilling DEFUSE-3 (Thrombectomy for Stroke at 6 to 16 Hours With Selection by Perfusion Imaging trial) DAWN 24 After a Mismatch Between Deficit Infarct inclusion criteria.Cohort study adults admitted between hours after last-seen-well 5 participating Swiss centers 2014 2021. was computer tomography or magnetic...
Brain invasion (BI) in meningiomas impacts WHO grading and therefore adjuvant treatment. However, BI is rare neurosurgical sampling neuropathological analyses are not standardised. Moreover, associations with imaging findings sparsely known. Associations between on preoperative MRI were investigated 617 meningioma patients. was strongly correlated other high-grade criteria (p<.001). Presence of a contrast enhancing tumour capsule, disruption the arachnoid layer, intratumoural calcifications...