A5024895384- Multiple Sclerosis Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Biotin and Related Studies
- Amyotrophic Lateral Sclerosis Research
- Biochemical and Structural Characterization
- Single-cell and spatial transcriptomics
- Botulinum Toxin and Related Neurological Disorders
- Myasthenia Gravis and Thymoma
- Immune responses and vaccinations
- Peripheral Neuropathies and Disorders
- Immune Response and Inflammation
- Polyomavirus and related diseases
- Neurological disorders and treatments
- Immune cells in cancer
- Parkinson's Disease Mechanisms and Treatments
Établissement Français du Sang
2021-2025
Inserm
2021-2025
Centre Hospitalier Universitaire de Nantes
2018-2021
Hôpital Saint-Jacques
2019
Multiple sclerosis (MS) is an immune-driven demyelinating disease of the central nervous system. Immune cell features are particularly promising as predictive biomarkers due to their role in pathogenesis but also drug targets, even if nowadays, they have no impact clinical practice. Recently, high-resolution approaches, such mass cytometry (CyTOF), helped better understand diversity and functions immune In this study, we performed exploratory analysis blood response profiles healthy controls...
Myeloid cells trafficking from the periphery to central nervous system are key players in multiple sclerosis (MS) through antigen presentation, cytokine secretion and repair processes. Combination of mass cytometry on blood 60 MS patients at diagnosis 29 healthy controls, along with single cell RNA sequencing paired cerebrospinal fluid (CSF) samples 5 were used for myeloid detailing. compartment study demonstrated an enrichment a peculiar classical monocyte population 22% time diagnosis....
Importance Vitamin D deficiency is a risk factor for multiple sclerosis (MS) and associated with the of disease activity, but data on benefits supplementation are conflicting. Objective To evaluate efficacy high-dose cholecalciferol as monotherapy in reducing activity patients clinically isolated syndrome (CIS) typical MS. Design, Setting, Participants The D-Lay MS trial was parallel, double-blind, randomized placebo-controlled clinical 36 centers France. Patients were enrolled from July...
Background: A recent controlled trial suggested that high-dose biotin supplementation reverses disability progression in patients with progressive multiple sclerosis. Objective: To analyze the impact of routine clinical practice on at 12 months. Methods: Progressive sclerosis who started Nantes or Rennes Hospital between 3 June 2015 and 15 September 2017 were included this prospective study. Disability outcome measures, patient-reported relapses, magnetic resonance imaging (MRI) data,...
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