A5012237817- Multiple Sclerosis Research Studies
- T-cell and B-cell Immunology
- Peripheral Neuropathies and Disorders
- Polyomavirus and related diseases
- Plant Reproductive Biology
- Systemic Sclerosis and Related Diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Immunotherapy and Immune Responses
- Fungal Plant Pathogen Control
Inserm
2020-2022
Université de Rennes
2022
Centre Hospitalier Universitaire de Rennes
2022
Institut de Transplantation Urologie en Nephrologie
2020
Center for Research in Transplantation and Translational Immunology
2020
Centre d'Investigation Clinique de Nantes
2020
Nantes Université
2020
Importance Vitamin D deficiency is a risk factor for multiple sclerosis (MS) and associated with the of disease activity, but data on benefits supplementation are conflicting. Objective To evaluate efficacy high-dose cholecalciferol as monotherapy in reducing activity patients clinically isolated syndrome (CIS) typical MS. Design, Setting, Participants The D-Lay MS trial was parallel, double-blind, randomized placebo-controlled clinical 36 centers France. Patients were enrolled from July...
Tertiary lymphoid structures and aggregates are reported in the meninges of patients with multiple sclerosis (MS), especially at progressive stage, strongly associated cortical lesions disability. Besides B cells, these comprise follicular helper T (Tfh) cells that crucial to support B-cell differentiation. Tfh play a pivotal role amplifying autoreactive promoting autoantibody production several autoimmune diseases, but very few known MS. In this study, we examined phenotype, frequency,...