A5055947590- Multiple Sclerosis Research Studies
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Systemic Sclerosis and Related Diseases
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Gut microbiota and health
- interferon and immune responses
- Macrophage Migration Inhibitory Factor
- Salivary Gland Disorders and Functions
- Cytokine Signaling Pathways and Interactions
- Prion Diseases and Protein Misfolding
- Psoriasis: Treatment and Pathogenesis
- Hereditary Neurological Disorders
- Adenosine and Purinergic Signaling
- Viral Infections and Immunology Research
- Mycobacterium research and diagnosis
- RNA regulation and disease
- Cytomegalovirus and herpesvirus research
- Dermatology and Skin Diseases
- Genomic variations and chromosomal abnormalities
- Peripheral Neuropathies and Disorders
- T-cell and Retrovirus Studies
Inserm
2017-2024
Nantes Université
2017-2024
Center for Research in Transplantation and Translational Immunology
2018-2024
Centre Hospitalier Universitaire de Nantes
2021-2024
Centre Hospitalier Universitaire de Nice
2023
Université de Montpellier
2023
Centre National de la Recherche Scientifique
2023
Institut de Génomique Fonctionnelle
2023
Centre Hospitalier Universitaire de Nîmes
2023
Université de Rennes
2022
Abstract In multiple sclerosis (MS), alterations of the gut microbiota lead to inflammation. However, role other microbiomes in body MS has not been fully elucidated. a pilot case-controlled study, we carried out simultaneous characterization faecal and oral conducted an in-depth analysis bacterial associated with MS. Using 16S rRNA sequencing metabolic inference tools, compared oral/faecal metabolism pathways French patients (n = 14) healthy volunteers (HV, n 21). A classification model...
Ocrelizumab (OCR), a humanized anti-CD20 monoclonal antibody, is highly efficient in patients with relapsing-remitting multiple sclerosis (RR-MS). We assessed early cellular immune profiles and their association disease activity at treatment start under therapy, which may provide new clues on the mechanisms of action OCR pathophysiology.A first group 42 an RR-MS, never exposed to disease-modifying was included 11 centers participating ancillary study ENSEMBLE trial (NCT03085810) evaluate...
Background and Objectives Inhibition of de novo pyrimidine synthesis in proliferating T B lymphocytes by teriflunomide, a pharmacological inhibitor dihydroorotate dehydrogenase (DHODH), has been shown to be an effective therapy treat patients with MS placebo-controlled phase 3 trials. Nevertheless, the underlying mechanism contributing efficacy DHODH inhibition only partially elucidated. Here, we aimed determine impact teriflunomide on immune compartment longitudinal high-dimensional...
Tertiary lymphoid structures and aggregates are reported in the meninges of patients with multiple sclerosis (MS), especially at progressive stage, strongly associated cortical lesions disability. Besides B cells, these comprise follicular helper T (Tfh) cells that crucial to support B-cell differentiation. Tfh play a pivotal role amplifying autoreactive promoting autoantibody production several autoimmune diseases, but very few known MS. In this study, we examined phenotype, frequency,...
Several lines of evidence support a key role for CD8+ T cells in central nervous system tissue damage patients with multiple sclerosis. However, the precise phenotype circulating that may be recruited from peripheral blood to invade CNS remains largely undefined date. It has been suggested IL-17 secreting CD8 (Tc17) involved, and humans these are characterized by expression CD161. We focused our study on unique recently described subset an intermediate CD161 as its neuroinflammation not...
MS is a chronic inflammatory disease of the CNS involving T cell and B responses. Recently, several studies have described modifications specific bacterium abundances gut microbiota in patients with remitting–relapsing compared healthy individuals (see for review1). This was often associated an increase Akkermansia muciniphila bacteria. In experimental autoimmune encephalomyelitis, transfer from to mice induced proinflammatory responses exacerbation disease, whereas volunteers (HVs) were...
Abstract Multiple sclerosis is an autoimmune disease of the central nervous system. Yet, targets are still undefined. The extracellular e1 sequence KCNJ10, inwardly rectifying potassium channel 4.1, has been subject to fierce debate for its role as a candidate autoantigen in multiple sclerosis. Inwardly 4.1 expressed system but also peripheral tissues, raising concerns about system-specificity such autoreactivity. Immunization C57Bl6/J female mice with peptide (amino acids 83–120 Kir4.1)...