A5015283577- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- T-cell and B-cell Immunology
- Renal Diseases and Glomerulopathies
- Immune Cell Function and Interaction
- Transplantation: Methods and Outcomes
- Bladder and Urothelial Cancer Treatments
- Adrenal and Paraganglionic Tumors
- Immunotherapy and Immune Responses
- Xenotransplantation and immune response
- Neurological Complications and Syndromes
- Urinary and Genital Oncology Studies
- Pancreatic function and diabetes
- Liver Disease and Transplantation
- Cancer, Hypoxia, and Metabolism
- Organ Donation and Transplantation
- Polyomavirus and related diseases
- Cytomegalovirus and herpesvirus research
- Renal and Vascular Pathologies
- Vasculitis and related conditions
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Medical Imaging and Pathology Studies
- Renal cell carcinoma treatment
- Pituitary Gland Disorders and Treatments
- Complement system in diseases
Inserm
2013-2025
Nantes Université
2014-2025
Center for Research in Transplantation and Translational Immunology
2020-2025
Centre Hospitalier Universitaire de Nantes
2015-2024
Hotel Dieu Hospital
2002-2023
Institut de Transplantation Urologie en Nephrologie
2004-2023
Hôtel-Dieu de Paris
2008-2023
RELX Group (United States)
2020
Centre d'Investigation Clinique de Nantes
2003-2019
Columbia University
2019
The 10th Banff Conference on Allograft Pathology was held in Banff, Canada from August 9 to 14, 2009. A total of 263 transplant clinicians, pathologists, surgeons, immunologists and researchers discussed several aspects solid organ transplants with a special focus antibody mediated graft injury. willingness the process adapt continuously response new research improve potential weaknesses, led implementation six working groups following areas: isolated v‐lesion, fibrosis scoring, glomerular...
Abstract The immune tolerance to rat kidney allografts induced by a perioperative treatment with anti-CD28 Abs is associated severe unresponsiveness of peripheral blood cells donor Ags. In this model, we identified an accumulation in the CD3−class II−CD11b+CD80/86+ plastic-adherent that additionally expressed CD172a as well other myeloid markers. These were able inhibit proliferation, but not activation, effector T and induce apoptosis contact-dependent manner. Their suppressive action was...
The angiotensin II type 1 receptor (AT1R) is an emerging target of functional non-HLA antibodies (Ab). We examined the potential determining degree presensitization against AT1R as a risk factor for graft survival and acute rejection (AR). study included 599 kidney recipients between 1998 2007. Serum samples were analyzed in blinded fashion anti-AT1R (AT1R-Abs) using quantitative solid-phase assay. A threshold AT1R-Ab levels was statistically determined at 10 U based on time to failure. An...
Accurate diagnosis and grading of rejection other pathological processes are paramount importance to guide therapeutic interventions in patients with pancreas allograft dysfunction. A multi-disciplinary panel pathologists, surgeons nephrologists was convened for the purpose developing a consensus document delineating histopathological features transplant biopsies. Based on available published data collective experience, criteria acute cell-mediated (ACMR) were established. Three severity...
The first Banff proposal for the diagnosis of pancreas rejection (Am J Transplant 2008; 8: 237) dealt primarily with acute T-cell-mediated (ACMR), while only tentatively addressing issues pertaining to antibody-mediated (AMR). This document presents comprehensive guidelines AMR, proposed at 10th Conference on Allograft Pathology and refined by a broad-based multidisciplinary panel. Pancreatic AMR is best identified combination serological immunohistopathological findings consisting (i)...
Cytokines and metabolic pathway-controlling enzymes regulate immune responses have potential as powerful tools to mediate tolerance. Blockade of the interaction between CD40 CD40L induces long-term cardiac allograft survival in rats through a CD8+CD45RClo Treg potentiation. Here, we shown that cytokine IL-34, immunoregulatory properties which not been previously studied transplantation or T cell biology, is expressed by rodent Tregs human FOXP3+CD45RCloCD8+ CD4+ Tregs. IL-34 was involved...
Exosomes are MHC-bearing vesicles secreted by a wide array of cells. We have previously shown that donor-haplotype exosomes from bone marrow dendritic cells (DCs) injected before transplantation significantly prolong heart allograft survival in congenic and fully MHC-mismatched Lewis rats. Here we show donor administered after similarly able to survival, however, without inducing tolerance. therefore tested the effect combined with short-term LF 15-0195 (LF) treatment, which blocks...
Long-term function of kidney allografts depends on multiple variables, one which may be the compatibility in size between graft and recipient. Here, we assessed long-term consequences ratio weight to recipient (KwRw ratio) a multicenter cohort 1189 patients who received transplant 1995 2006. The filtration rate increased by mean 5.74 ml/min third sixth posttransplantation months among with low KwRw (<2.3 g/kg; P < 0.0001). In this group, remained stable 6 7 years but then decreased at 3.17...
Buffalo/Mna rats spontaneously develop FSGS and nephrotic syndrome as a result of an immune disorder. Similar to some humans with FSGS, the disease recurs after renal transplantation, suggesting involvement circulating factor. Here, we tested effect several immunosuppressive treatments on these rats. Although corticosteroids, cyclosporin A, anti–T cell receptor treatment reduced proteinuria, only deoxyspergualin derivative LF15-0195 led rapid complete normalization proteinuria. Furthermore,...
In renal transplantation, the unresponsiveness of patients undergoing chronic antibody mediated rejection (CAMR) to classical treatment stress on need for accurate biomarkers improve its diagnosis. We aim determine whether microRNA expression patterns may be associated with a diagnosis CAMR. performed profiling miRNAs in peripheral blood mononuclear cells (PBMC) kidney transplant recipients CAMR or stable graft function. Among 257 expressed miRNAs, 10 were selected. them, miR-142-5p was...
Selective targeting of CD28 might represent an effective immunomodulation strategy by preventing T cell costimulation, while favoring coinhibition since inhibitory signals transmitted through CTLA-4; PD-L1 and B7 would not be affected. We previously showed in vitro vivo that anti-CD28 antagonists suppress effector cells enhancing regulatory (Treg) suppression immune tolerance. Here, we evaluate FR104, a novel antagonist pegylated Fab' antibody fragment, nonhuman primate renal...
Long-term renal transplant outcome is limited by side effects of immunosuppressive drugs, particularly calcineurin inhibitor (CNI). We assumed that some patients selected for a "low immunological risk rejection" could be eligible and benefit from CNI weaning strategy. designed prospective, randomized, multicenter, double-blind placebo-controlled clinical study (Eudract: 2010-019574-33) to analyze the benefit-risk ratio tacrolimus on highly (≥4 years transplantation, normal histology, stable...
Diagnosis of the specific cause late allograft injury is necessary if more personalized and efficient immunosuppressive regimens are to be introduced. This study sought previously unrecognized biomarkers for histologic diagnoses graft scarring by comparison gene sets from published microarray studies. Tribbles-1 (TRIB1), a human homolog Drosophila tribbles, was identified potentially informative biomarker. For testing this, mRNA expression in 76 biopsies, 71 blood samples, 11 urine samples...
Belatacept is a biologic that targets CD80/86 and prevents its interaction with CD28 alternative ligand, cytotoxic T lymphocyte antigen 4 (CTLA-4). Clinical experience in kidney transplantation has revealed high incidence of rejection belatacept, especially intensive regimens, suggesting blocking CTLA-4 deleterious. We performed head to assessment FR104 ( n =5), selective pegylated Fab′ antibody fragment antagonist does not block the pathway, belatacept =5) allotransplantation baboons. The...
Cytology and cystoscopy, the current gold standard for diagnosing urothelial carcinomas, have limits: cytology has high interobserver variability with moderate or not optimal sensitivity (particularly low-grade tumors); while cystoscopy is expensive, invasive, operator dependent. The VISIOCYT1 study assessed benefit of VisioCyt® carcinoma.VISIOCYT1 was a French prospective clinical trial conducted in 14 centers. enrolled adults undergoing endoscopy suspected bladder cancer to explore lower...
Abstract Previous work on blockade of CD40-CD40 ligand interaction in mice and primates with anti-CD40 mAbs has resulted a moderate prolongation allograft survival without the development true tolerance. In this study, we show rats that adenovirus-mediated gene transfer CD40Ig sequences into graft prolonged (&gt;200 days) expression long-term (&gt;300 survival. Recipients expressing displayed strongly (&gt;90%) inhibited mixed leukocyte reactions alloantibody production at early...