A5024799633- Renal Diseases and Glomerulopathies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Renal Transplantation Outcomes and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Parathyroid Disorders and Treatments
- Polyomavirus and related diseases
- Complement system in diseases
- Vasculitis and related conditions
- Autoimmune Bullous Skin Diseases
- HIV/AIDS drug development and treatment
- Neuroendocrine Tumor Research Advances
- Chronic Lymphocytic Leukemia Research
- Eosinophilic Disorders and Syndromes
- Chronic Kidney Disease and Diabetes
- IgG4-Related and Inflammatory Diseases
- Transplantation: Methods and Outcomes
- Bladder and Urothelial Cancer Treatments
- Genetic and Kidney Cyst Diseases
- Cystic Fibrosis Research Advances
- Renal and related cancers
- Systemic Lupus Erythematosus Research
- Lymphoma Diagnosis and Treatment
- Parvovirus B19 Infection Studies
- Neurological Complications and Syndromes
- Diagnosis and treatment of tuberculosis
Hôpitaux Universitaires Henri-Mondor
2015-2025
Institut Mondor de Recherche Biomédicale
2016-2025
Inserm
2014-2025
Assistance Publique – Hôpitaux de Paris
2013-2024
Université Paris-Est Créteil
2014-2024
Hôpital Albert-Chenevier
2016-2023
Centre Hospitalier Universitaire Henri-Mondor
2013-2022
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2022
CEA Paris-Saclay - Etablissement de Fontenay-aux-roses
2022
Université Gustave Eiffel
2021
Abstract Background The coronavirus disease 2019 (COVID-19) may be associated with kidney injury, which impact patient's prognosis. Methods We report a multicentric retrospective case series of patients COVID-19 who developed acute injury (AKI) and/or proteinuria and underwent biopsy in Paris its metropolitan area. Results Forty-seven (80.9% men) between 8 March 19 May 2020 were included. median age was 63 years (interquartile range 52–69). Comorbidities included hypertension (66.0%),...
Data from the PEXIVAS trial challenged role of plasma exchange (PLEX) in ANCA-associated vasculitides (AAV). We aimed to describe kidney biopsy patients with AAV treated PLEX, evaluate whether histopathologic findings could predict function, and identify which would most benefit PLEX.We performed a multicenter, retrospective study on 188 AKI PLEX 237 not PLEX. The primary outcome was mortality or KRT at 12 months (M12).No significant for found. To benefitting we developed model predicting...
The benefit of belatacept on antibody-mediated rejection (ABMR) incidence after kidney transplant with preformed donor-specific antibodies (DSAs) has never been assessed. Between 2014 and 2016, we conducted a multicenter prospective clinical trial 49 patients to determine allograft outcome in recipients DSAs (maximal mean fluorescence intensity 500 3000) treated (BELACOR trial). Immunosuppressive strategy included antithymocyte globulin, belatacept, mycophenolate mofetil, steroids. An...
Abstract Background The recent success achieved with the use of B cell-depleting agents in some patients minimal change nephrotic syndrome (MCNS) suggests an unexpected role for lymphocytes pathogenesis this immune-mediated glomerular disease. Nevertheless, no extensive B-cell phenotyping analysis has ever been performed untreated adult soon after MCNS diagnosis. Methods We investigated distribution different subpopulations 22 biopsy-proven [MCNS relapse (MCNS-Rel)]. compared these data...
Cardiac amyloidosis (CA) has a poor prognosis which is aggravated by diagnostic delay. Amyloidosis extracardiac and cardiac events (AECE ACE) may help improve CA diagnosis typing. The aim of this study was to compare AECE ACE between different types assess their relationship with survival.This retrospective cohort conducted in France from June 2008 May 2019, at the Henry Mondor Hospital. This included 983 patients CA. Mean age inclusion 73.1 ± 11.4 years, 726 (75.1%) were male mean body mass...
Few studies have examined the occurrence of minimal change nephrotic syndrome (MCNS) in patients with non-Hodgkin lymphoma (NHL). We report here a series 18 MCNS occurring among 13,992 new cases NHL. analyzed clinical and pathologic characteristics this association, along response to treatment, determine if association relies on particular disorder. The most frequent NHLs associated were Waldenström macroglobulinemia (33.3%), marginal zone B-cell (27.8%), chronic lymphocytic leukemia...
Abstract Basal/squamous (Ba/Sq) subtype represents an intrinsic and robust group in the consensus molecular classification of muscle‐invasive bladder cancer (MIBC), with poor outcome controversial chemosensitivity. We aimed to investigate spectrum intratumor heterogeneity (ITH) Ba/Sq subtype. First, we validated a 29‐gene NanoString CodeSet predict for FFPE samples. identified heterogeneous tumors series 331 MIBC samples using dual GATA3/KRT5/6 immunohistochemistry (IHC). Heterogeneous...
Key Points We evidenced terminal pathway activation (C5b-9 deposits) in most of the glomeruli on kidney biopsy C3 glomerulopathy. The amount C5b-9 deposits correlated with disease prognosis Increased was found predominantly a subgroup exhibiting an immuno-fibroblastic signature. Background glomerulopathy is rare resulting from overactivation complement alternative pathway. Although there also evidence activation, its occurrence and consequences have been poorly studied. Methods...
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