A5081652574- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Renal cell carcinoma treatment
- Renal and related cancers
- Esophageal Cancer Research and Treatment
- Urologic and reproductive health conditions
- Healthcare Policy and Management
- Pediatric Urology and Nephrology Studies
- Multiple and Secondary Primary Cancers
- Epigenetics and DNA Methylation
- Testicular diseases and treatments
- Renal Transplantation Outcomes and Treatments
- Cancer, Lipids, and Metabolism
- Renal and Vascular Pathologies
- Cancer Genomics and Diagnostics
- Cancer Research and Treatments
- Ferroptosis and cancer prognosis
- Prostate Cancer Diagnosis and Treatment
- Organ Donation and Transplantation
- Colorectal Cancer Screening and Detection
- Prostate Cancer Treatment and Research
- Infectious Disease Case Reports and Treatments
- Genetic factors in colorectal cancer
- Tissue Engineering and Regenerative Medicine
The University of Texas Southwestern Medical Center
2014-2025
Texas Medical Center
2014-2017
University of California System
2017
Southwestern Medical Center
2005-2016
The University of Texas at Austin
2010-2011
Southwestern University
2011
Ludwig-Maximilians-Universität München
2009-2010
Université de Montréal
2006-2009
Université Laval
2009
University of Bonn
2009
We present the characteristics and outcomes of a large, contemporary, consecutive series patients treated with radical cystectomy pelvic lymphadenectomy for transitional cell carcinoma bladder.We developed multi-institutional database collected retrospective prospective data on 888 bladder who were at 3 academic centers in United States between 1984 2003.Of 25% had extravesical tumor extension negative lymph nodes 23% node metastasis. The rate involvement increased advancing pathological...
Purpose We hypothesized that bladder cancer patients with associated lymphovascular invasion (LVI) are at increased risk of occult metastases. Methods A multi-institutional group (University Texas Southwestern [Dallas, TX], Baylor College Medicine [Houston, Johns Hopkins University [Baltimore, MD]) carried out a retrospective study 958 who underwent cystectomy for between 1984 and 2003. Of transitional-cell carcinoma (n = 776), LVI status was available 750. defined as the presence tumor...
Abstract Aims: To develop multivariate nomograms that determine the probabilities of all-cause and bladder cancer–specific survival after radical cystectomy to compare their predictive accuracy American Joint Committee on Cancer (AJCC) staging. Methods: We used Cox proportional hazards regression analyses model variables 731 consecutive patients treated with bilateral pelvic lymphadenectomy for transitional cell carcinoma. Variables included age patient, gender, pathologic stage (pT), grade,...
American Joint Committee on Cancer staging represents the gold standard for prediction of recurrence after radical cystectomy in patients with invasive bladder cancer. We tested hypothesis that stage based predictions may be improved when pathological tumor and node information is combined additional clinical variables within a prognostic nomogram.We used Cox proportional hazards regression analysis to model 728 transitional cell carcinoma treated bilateral pelvic lymphadenectomy at 1 3...
Background Tuberous sclerosis (TSC) related tumors are characterized by constitutively activated mTOR signaling due to mutations in TSC1 or TSC2. Methods We completed a phase 2 multicenter trial evaluate the efficacy and tolerability of inhibitor, sirolimus, for treatment kidney angiomyolipomas. Results 36 adults with TSC TSC/LAM were enrolled started on daily sirolimus. The overall response rate was 44.4% (95% confidence intervals [CI] 28 61); 16/36 had partial response. remainder stable...
Tested was whether the assessment of 5 established bladder cancer biomarkers (p53, pRB, p21, p27, and cyclin E1) could improve ability to predict disease recurrence cancer-specific survival after radical cystectomy in patients with pTa-3N0M0 urothelial carcinoma (UCB).The study comprised 191 UCB treated bilateral lymphadenectomy (median follow-up, 3.1 years). Biomarker expression assayed on serial tissue microarray slides using quantitative immunohistochemistry advanced cell imaging color...
We evaluated the association of soft tissue surgical margins with characteristics and outcomes patients treated radical cystectomy for urothelial carcinoma bladder.We retrospectively collected data 4,410 pelvic lymphadenectomy without neoadjuvant chemotherapy at 12 academic centers in United States, Canada Europe. A positive margin was defined as presence tumor inked areas on specimen.Positive were identified 278 (6.3%). On univariate analysis significantly associated advanced pT stage,...
The effect of bladder cancer histological subtypes other than transitional cell carcinoma (nonTCC) on clinical outcomes remains uncertain. We conducted a multi-institutional retrospective study patients with treated radical cystectomy to assess the impact nonTCC histology specific outcomes.A total 955 consecutive underwent bilateral pelvic lymphadenectomy for at 3 academic institutions. TCC was present in specimen 888 (93%). NonTCC 67 (7%), including squamous 26, adenocarcinoma 13, small 10...
We developed and validated nomograms that accurately predict disease recurrence progression in patients with Ta, T1, or CIS transitional cell carcinoma (TCC) of the bladder using a large international cohort.Univariate multivariate logistic regression models targeted histologically confirmed recurrence, focused on 2,542 TCC from 10 participating centers. Variables consisted pre-cystoscopy voided urine Nuclear Matrix Protein 22 (NMP22) assay, cytology, age gender. Resulting were internally...
Most anticancer drugs entering clinical trials fail to achieve approval from the U.S. Food and Drug Administration. development is hampered by lack of preclinical models with therapeutic predictive value. Herein, we report validation a tumorgraft model renal cell carcinoma (RCC) its application evaluation an experimental drug. Tumor samples 94 patients were implanted in kidneys mice without additives or disaggregation. Tumors 35 these formed tumorgrafts, 16 stable lines established. Samples...