A5091753897- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Urinary and Genital Oncology Studies
- Renal and related cancers
- Cancer Genomics and Diagnostics
- Urological Disorders and Treatments
- Multiple and Secondary Primary Cancers
- Testicular diseases and treatments
- Esophageal Cancer Research and Treatment
- Prostate Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Urologic and reproductive health conditions
- Prostate Cancer Treatment and Research
- Ferroptosis and cancer prognosis
- Sarcoma Diagnosis and Treatment
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Epigenetics and DNA Methylation
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Lipids, and Metabolism
- Pediatric Urology and Nephrology Studies
- Cancer Diagnosis and Treatment
- Cardiac tumors and thrombi
- Ureteral procedures and complications
- Pancreatic and Hepatic Oncology Research
The University of Texas Southwestern Medical Center
2016-2025
Southwestern Medical Center
2016-2025
Advanced Imaging Research (United States)
2025
Brigham and Women's Hospital
2025
Sechenov University
2019-2023
Creative Commons
2023
Lomonosov Moscow State University
2019-2022
Harold C. Simmons Comprehensive Cancer Center
2019-2022
Bristol-Myers Squibb (Germany)
2022
Astellas Pharma (China)
2022
The literature on upper tract urothelial carcinoma (UTUC) has been limited to small, single center studies. A large series of patients treated with radical nephroureterectomy for UTUC were studied, and variables associated poor prognosis identified.Data 1363 at 12 academic centers collected. All pathologic slides re-reviewed by genitourinary pathologists according strict criteria.Pathologic review revealed renal pelvis location (64%), necrosis (21.6%), lymphovascular invasion (LVI) (24.8%),...
Purpose To assess the association of lymphovascular invasion (LVI) with cancer recurrence and survival in a large international series patients treated radical nephroureterectomy (RNU) for upper urinary tract urothelial carcinoma (UTUC). Patients Methods Data were collected on 1,453 RNU at 13 academic centers combined into relational database. Pathologic slides rereviewed by genitourinary pathologists according to strict criteria. LVI was defined as presence tumor cells within an...
The NCCN Guidelines for Bladder Cancer provide recommendations the diagnosis, evaluation, treatment, and follow-up of patients with bladder cancer other urinary tract cancers (upper tumors, urothelial carcinoma prostate, primary urethra). These Insights summarize panel discussion behind recent important updates to guidelines regarding treatment non–muscle-invasive cancer, including how treat in event a bacillus Calmette-Guérin (BCG) shortage; new roles immune checkpoint inhibitors non–muscle...
Most kidney cancers are metabolically dysfunctional
Abstract BACKGROUND: The authors evaluated the incidence of pathologic downstaging and complete remission (CR) in patients with high‐grade ureteral renal pelvic transitional cell carcinoma (TCC) (upper tract TCC) who received neoadjuvant chemotherapy followed by surgery. METHODS: study group comprised biopsy‐demonstrated, disease nephrouterectomy from 2004 to 2008, during which time uniformly were considered for chemotherapy. control underwent initial nephroureterectomy 1993 2004, when...
There is relatively little literature on adjuvant chemotherapy after radical nephroureterectomy in patients with upper tract urothelial carcinoma. We determined the incidence of high risk and ensuing effect overall cancer specific survival.Using an international collaborative database we identified 1,390 who underwent for nonmetastatic carcinoma between 1992 2006. Of these cases 542 (39%) were classified as (pT3N0, pT4N0 and/or lymph node positive). These divided into 2 groups, including...
Abstract BACKGROUND: The benefits of cytoreductive nephrectomy (CN) in metastatic renal cell carcinoma (mRCC) should outweigh surgical morbidity. Even when the generally agreed upon selection criteria for CN are met, some patients do poorly after surgery. objective this study was to identify preoperative factors that were prognostic outcome who being considered CN. METHODS: authors conducted a retrospective investigate overall survival (OS) underwent using OS with mRCC did not undergo as...
We created a prognostic tool for the accurate preoperative prediction of nonorgan confined upper tract urothelial carcinoma.A computerized data bank containing comprehensive information on 1,453 patients who underwent radical nephroureterectomy at 13 academic institutions was generated and continuously updated. This study comprised subset 659 in whom all appropriate variables (age, gender, race, symptoms, Eastern Cooperative Oncology Group performance status, primary tumor location,...
We examined the impact of lymphadenectomy on clinical outcomes patients with upper tract urothelial cancer treated radical nephroureterectomy.Data were collected 1,130 consecutive pT1-4 nephroureterectomy at 13 centers worldwide. Patients grouped according to nodal status (pN0 vs pNx pN+). The choice perform was determined by treating surgeon. All pathology slides reevaluated dedicated genitourinary pathologists. Univariable and multivariable Cox regression models measured association pN+)...
Most anticancer drugs entering clinical trials fail to achieve approval from the U.S. Food and Drug Administration. development is hampered by lack of preclinical models with therapeutic predictive value. Herein, we report validation a tumorgraft model renal cell carcinoma (RCC) its application evaluation an experimental drug. Tumor samples 94 patients were implanted in kidneys mice without additives or disaggregation. Tumors 35 these formed tumorgrafts, 16 stable lines established. Samples...
BACKGROUND High‐grade upper tract urothelial carcinoma (UTUC) is frequently upstaged after surgery and associated with uniformly poor survival. Neoadjuvant chemotherapy may offer a way to improve clinical outcomes. The authors compared the survival rates of patients UTUC who received neoadjuvant before among did not. METHODS A retrospective review was conducted high‐risk followed by from 2004 2008 (study group) matched cohort underwent initial 1993 2003 (control group). Fisher exact tests,...
OBJECTIVE To assess whether tumour architecture can help to refine the prognosis of patients treated with nephroureterectomy (NU) for urothelial carcinoma (UC) upper urinary tract (UT), as prognostic value (papillary vs sessile) in UTUC remains elusive. PATIENTS AND METHODS The study included 1363 and radical NU at 12 centres worldwide. All slides were re‐reviewed according strict criteria by genitourinary pathologists who unaware findings original pathology clinical outcomes. Gross was...