A5044684517- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- DNA Repair Mechanisms
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Neuroblastoma Research and Treatments
- Advanced MRI Techniques and Applications
- Advanced biosensing and bioanalysis techniques
- Neurogenesis and neuroplasticity mechanisms
- Advanced NMR Techniques and Applications
- Epigenetics and DNA Methylation
- Single-cell and spatial transcriptomics
- Cancer-related molecular mechanisms research
- Barrier Structure and Function Studies
- Cancer-related Molecular Pathways
- Chemical Reactions and Isotopes
- RNA Interference and Gene Delivery
- Photoacoustic and Ultrasonic Imaging
- Nanoplatforms for cancer theranostics
- Neuroscience and Neuropharmacology Research
- Telomeres, Telomerase, and Senescence
- Cancer Research and Treatments
- Circular RNAs in diseases
Dana-Farber Cancer Institute
2003-2025
The University of Texas Southwestern Medical Center
2015-2024
Southwestern Medical Center
2013-2024
Neurology, Inc
2009-2023
Center for Neuro-Oncology
2013-2023
Harold C. Simmons Comprehensive Cancer Center
2014-2023
The University of Texas at Dallas
2020
Nanotherapeutics (United States)
2014-2020
The University of Texas at Arlington
2020
VA North Texas Health Care System
2013-2016
Human solid tumors frequently have pronounced heterogeneity of both neoplastic and normal cells on the histological, genetic, gene expression levels. While current efforts are focused understanding heterotypic interactions between tumor surrounding cells, much less is known about among heterogeneous within a neoplasm. In glioblastoma multiforme (GBM), epidermal growth factor receptor (EGFR) amplification mutation (EGFRvIII/DeltaEGFR) signature pathogenetic events that invariably expressed in...
Activation of the transcription factor STAT3 is thought to potently promote oncogenesis in a variety tissues, leading intense efforts develop inhibitors for many tumors, including highly malignant brain tumor glioblastoma. However, function glioblastoma pathogenesis has remained unknown. Here, we report that plays pro-oncogenic or tumor-suppressive role depending on mutational profile tumor. Deficiency suppressor PTEN triggers cascade inhibits signaling murine astrocytes and human tumors....
Glioblastomas and brain metastases demonstrate avid uptake of 2‐[ 18 F]fluoro‐2‐deoxyglucose by positron emission tomography display perturbations intracellular metabolite pools 1 H MRS. These observations suggest that metabolic reprogramming contributes to tumor growth in vivo . The Warburg effect, excess metabolism glucose lactate the presence oxygen, is a hallmark cancer cells culture. F]Fluoro‐2‐deoxyglucose‐positive tumors are assumed metabolize similar manner, with high rates formation...
Chondroitin sulfate proteoglycans (CSPGs) are a family of extracellular matrix molecules with various functions in regulating tissue morphogenesis, cell division, and axon guidance. A number CSPGs highly upregulated by reactive glial scar tissues after injuries form strong barrier for axonal regeneration the adult vertebrate CNS. Although may negatively regulate growth via binding altering activity other growth-regulating factors, molecular mechanisms which restrict elongation not well...
Glial cells can be in vivo reprogrammed into functional neurons the adult CNS; however, process by which this reprogramming occurs is unclear. Here, we show that a distinct cellular sequence involved SOX2-driven situ conversion of astrocytes to neurons. This includes ASCL1+ neural progenitors and DCX+ neuroblasts (iANBs) as intermediates. Importantly, ASCL1 required, but not sufficient, for robust generation iANBs striatum. These progenitor-derived predominantly give rise calretinin+...
Purpose Proton magnetic resonance spectroscopy (MRS) of the brain can detect 2-hydroxyglutarate (2HG), oncometabolite produced in neoplasms harboring a mutation gene coding for isocitrate dehydrogenase ( IDH). We conducted prospective longitudinal imaging study to determine whether quantitative assessment 2HG by MRS could serve as noninvasive clinical biomarker IDH-mutated gliomas. Patients and Methods was performed 136 patients using point-resolved at 3 T parallel with standard assessment....
Glioblastoma multiforme (GBM) is the most lethal of brain tumors and highly resistant to ionizing radiation (IR) chemotherapy. Here, we report on a molecular mechanism by which key glioma-specific mutation, epidermal growth factor receptor variant III (EGFRvIII), confers resistance. Using Ink4a/Arf-deficient primary mouse astrocytes, astrocytes immortalized p53/Rb suppression, as well human U87 glioma cells, show that EGFRvIII expression enhances clonogenic survival following IR. This...
Glioblastomas (GBM) are lethal brain tumors that highly resistant to therapy. The only meaningful improvement in therapeutic response came from use of the S(N)1-type alkylating agent temozolomide combination with ionizing radiation. However, no genetic markers might predict a better DNA agents have been identified GBMs, except for loss O(6-)methylguanine-DNA methyltransferase via promoter methylation. In this study, using genetically defined primary murine astrocytes as well human glioma...
Abstract Purpose: Telomerase activity is one of the hallmarks cancer and a highly relevant therapeutic target. The effects novel human telomerase antagonist, imetelstat, on primary glioblastoma (GBM) tumor-initiating cells were investigated in vitro vivo. Experimental Design: Tumor-initiating isolated from GBM tumors expanded as neurospheres vitro. treated with imetelstat examined for levels, telomere length, proliferation, clonogenicity, differentiation. Subsequently, mouse orthotopic...
The astrocyte represents the most abundant yet least understood cell type of CNS. Here, we use a stringent experimental strategy to molecularly define lineage by integrating microarray datasets across several in vitro model systems differentiation, primary cultures, and various astrocyterich CNS structures. intersection data sets, coupled with application nonastrocytic exclusion filters, yielded many astrocyte-specific genes possessing strikingly varied patterns regional expression....
The PTEN protein has a single catalytic domain possessing both lipid phosphoinositol and phosphatase activities. activity is essential for to block the cell cycle in G1 phase thereby suppress tumor formation progression (Cantley, L. C., Neel, B. G. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 4240-4245), although mechanisms governing under normal neoplastic growth conditions remain unclear. Here, we report that interacts physically functionally with PCAF, histone acetyltransferase regulates...