A5071638446- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- MRI in cancer diagnosis
- Functional Brain Connectivity Studies
- Lanthanide and Transition Metal Complexes
- Medical Imaging Techniques and Applications
- Advanced NMR Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Atomic and Subatomic Physics Research
- NMR spectroscopy and applications
- EEG and Brain-Computer Interfaces
- Mitochondrial Function and Pathology
- Neurological and metabolic disorders
- Optical Imaging and Spectroscopy Techniques
- Liver Disease Diagnosis and Treatment
- Neural dynamics and brain function
- Radiomics and Machine Learning in Medical Imaging
- Neuroscience and Neuropharmacology Research
- Breast Lesions and Carcinomas
- Breast Cancer Treatment Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
Gachon University
2018-2025
Seoul National University of Science and Technology
2020
Korea University of Science and Technology
2013-2016
Medical College of Wisconsin
2016
Korea Basic Science Institute
2012-2016
The University of Texas Southwestern Medical Center
2009-2012
Advanced Imaging Research (United States)
2012
University of California, Irvine
2007-2009
Structural changes in water molecules are related to physiological, anatomical and pathological properties of tissues. Near infrared (NIR) optical absorption methods sensitive water; however, detailed characterization thick tissues is difficult achieve because subtle spectral shifts can be obscured by multiple light scattering. In the NIR, a peak observed around 975 nm. The precise NIR peak's shape position highly molecular disposition. We introduce bound index (BWI) that quantifies tissue...
Salvia miltiorrhiza (SM) has been used in oriental medicine for its neuroprotective effects against cardiovascular diseases and ischemic stroke. In this study, we investigated the therapeutic mechanism underlying of SM on stroke using a transient middle cerebral artery occlusion (tMCAO) mouse model. Our results showed that administration significantly attenuated acute brain injury, including infarction neurological deficits, 3 days after tMCAO. This was confirmed by our magnetic resonance...
The aim of this study was to determine whether tumor size, MRS parameters and apparent diffusion coefficient (ADC) measurements could be applied predict pathologic complete response (pCR) after neoadjuvant chemotherapy (NAC). Ninety patients with breast cancer (median 4.5 cm; range, 1.6–9.5 cm) were evaluated single‐voxel 1 H dynamic contrast‐enhanced MRI. Diffusion‐weighted imaging performed in 41 these using a 1.5‐T scanner before completion NAC. Pre‐ post‐treatment changes [absolute...
The purpose of this article is to determine whether the peak integral and signal-to-noise ratio (SNR) total choline-containing compounds obtained by MR spectroscopy (MRS) correlate with histologic biomarkers currently used for predicting prognosis in patients breast cancer.Single-voxel proton MRS using a 1.5-T scanner was performed 184 (mean age, 48 years; range, 28-72 years) cancer. We absolute compound integral, normalized volume interest, SNR after MRI. On surgical pathology, pathologic...
Purpose In-vivo proton magnetic resonance spectroscopy (MRS) is a non-invasive method of analyzing choline metabolism that has been used to predict breast cancer prognosis. A strong peak may be surrogate for aggressive tumor biology but its clinical relevance unclear. The present study assessed whether total (tCho), as measured by MRS, can late recurrence in patients with hormone receptor (HR)-positive, HER2-negative early cancer. Methods cohort included 261 HR+/HER2- who underwent...
Stroke affects over 12 million people annually, leading to high mortality, long-term disability, and substantial healthcare costs. Although East Asian herbal medicines are widely used for stroke treatment, the pathways of operation they use remain poorly understood. Our study investigates neuroprotective properties Astragalus mongholicus (AM) in acute ischemic using photothrombotic (PTB) transient middle cerebral artery occlusion (tMCAO) mouse models, as well an vitro oxygen-glucose...
Abstract Background The parkin-interacting substrate (PARIS, also known as ZNF746) is a transcriptional repressor, whose accumulation and phosphorylation play central pathological roles in Parkinson’s disease (PD). PARIS-induced repression of PGC-1α or MDM4 contributes to mitochondrial dysfunction p53-dependent neuron loss PD. Despite the important role PARIS PD pathogenesis, unbiased transcriptomic profiles influenced by dopaminergic neurons remain unexplored. Methods We engineered Tet-Off...
Abstract Purpose To compare the MRI features between estrogen receptor (ER) positive and negative breast cancers. Materials Methods Breast of 90 consecutive patients confirmed with invasive ductal carcinoma (IDC), 51 ER 39 negative, were analyzed. The tumor morphology dynamic contrast‐enhanced (DCE) kinetics evaluated based on American College Radiology (ACR) Imaging Reporting Data System (BI‐RADS) lexicon compared. Enlarged axillary lymph nodes choline (Cho) detection using MR spectroscopy...
Rheumatoid arthritis (RA) is an autoimmune disease characterized by aggressive fibroblast-like synoviocytes (FLSs) and pannus formation. Various therapeutic strategies have been developed against inflammatory cytokines in RA recent decades. Based on the migratory features of FLSs, we examined whether modulation module attenuates severity. In this study, inflamed synovial fluid-stimulated FLSs exhibited enhanced migration apparatus expression, sodium bicarbonate cotransporter n1 (NBCn1) was...
Abstract Purpose To investigate the application of MR spectroscopy using chemical‐shift imaging (CSI) for characterizing human breast lesions at 1.5T, and to evaluate diagnostic performance ROC (receiver operating characteristics) analysis. Materials Methods Thirty‐six patients (35–73 years old, mean 52), with 27 malignant 9 benign lesions, underwent anatomical imaging, dynamic contrast‐enhanced CSI. The analysis was performed cutoff point yielding highest accuracy found be a choline (Cho)...
The purpose of this study was to evaluate the role high-resolution magic angle spinning (HR-MAS) 1H nuclear magnetic resonance (NMR) spectroscopy in patients with ductal carcinoma situ (DCIS) diagnosed on preoperative biopsy. We investigated whether metabolic profiling tissue samples using HR-MAS NMR could be used distinguish between DCIS lesions or without an invasive component. Our institutional review board approved combined retrospective and prospective study. Tissue were collected from...
The purpose of this study was to investigate the usefulness quantitative proton magnetic resonance spectroscopy ((1)H-MRS) for characterizing breast lesions at 1.5T, and evaluate diagnostic performance in vivo (1)H-MRS using receiver operating characteristics (ROC) analysis. 112 patients (99 malignant 13 benign tumors) who were scanned with MRI/MRS protocol included study. Choline-containing compounds (tCho) levels measured compared histological findings. tCho work had range 0.08-9.99...
Changes in brain morphometry have been extensively reported various studies examining the effects of chronic alcohol use alcohol-dependent patients. Such were able to confirm association between and volumetric reductions subcortical structures using FSL (FMRIB software library). However, each study that utilized had different sets showed significant reduction. First, we aimed investigate reproducibility assess differences patients control subjects. Second, Vertex analysis, a less program,...
This study aimed to investigate morphological and metabolic changes in the brains of 5xFAD mice. Structural magnetic resonance imaging (MRI) 1H spectroscopy (MRS) were obtained 10- 14-month-old wild-type (WT) mice, while 31P MRS scans acquired 11-month-old Significantly reduced gray matter (GM) was identified by voxel-based morphometry (VBM) thalamus, hypothalamus, periaqueductal areas mice compared WT Significant reductions N-acetyl aspartate elevation myo-Inositol revealed quantification...
The morphology of the brain undergoes changes throughout aging process, and accurately predicting a person’s age gender using features can aid in detecting atypical patterns. Neuroimaging-based estimation is commonly used to assess an individual’s health relative typical trajectory, while classifying from neuroimaging data offers valuable insights into inherent neurological differences between males females. In this study, we aimed compare efficacy classical machine learning models with that...
Even though many previous studies have reported structural or functional brain abnormalities in patients with alcohol dependence (ADPs), observing the and associated clinical characteristics of ADPs utilizing a multimodal approach are still scarce. The aim this study was to demonstrate their association alcoholism male ADPs. Fifteen healthy controls (HCs) 15 who had been diagnosed according Diagnostic Statistical Manual Mental Disorders 5 criteria underwent T1-weighted imaging resting-state...