A5080059317- RNA modifications and cancer
- RNA Research and Splicing
- Neuroscience and Neuropharmacology Research
- Cancer-related molecular mechanisms research
- Neurogenesis and neuroplasticity mechanisms
- RNA and protein synthesis mechanisms
- RNA regulation and disease
- MicroRNA in disease regulation
- Alzheimer's disease research and treatments
- Genomics and Rare Diseases
- Long-Term Effects of COVID-19
- Inflammatory Biomarkers in Disease Prognosis
- Mitochondrial Function and Pathology
- Tryptophan and brain disorders
- Epigenetics and DNA Methylation
- Neuroinflammation and Neurodegeneration Mechanisms
- Bioinformatics and Genomic Networks
- Parkinson's Disease Mechanisms and Treatments
- COVID-19 and healthcare impacts
- Ubiquitin and proteasome pathways
- Cellular transport and secretion
- interferon and immune responses
- Ginseng Biological Effects and Applications
- SARS-CoV-2 and COVID-19 Research
- Autophagy in Disease and Therapy
Hanyang University
2007-2025
Korea Brain Research Institute
2019-2021
The University of Texas Southwestern Medical Center
2014-2017
The University of Tokyo
2011
Homeostatic scaling allows neurons to maintain stable activity patterns by globally altering their synaptic strength in response changing levels. Suppression of the blocking action potentials increases through an upregulation surface α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. Although this upscaling was shown require transcription, molecular nature intrinsic transcription program underlying process and its functional significance have been unclear. Using RNA-seq,...
The prolonged effects of N-methyl-D-aspartate (NMDA) receptor activation on the proliferation and differentiation hippocampal neural progenitor cells (NPCs) were studied. Under conditions mitogen-mediated proliferation, a single NMDA pulse (5 microM) increased fraction 5-bromo-2-deoxyuridine (BrdU)-positive (BrdU(+)) after delay 72 hours. Similarly, systemic injection (100 mg/kg) number BrdU(+) in dentate gyrus (DG) 28 days, but not 3 days. induced an immediate influx Ca(2+) into NPCs...
Glutamate receptor (GluR) δ1 is widely expressed in the developing forebrain, whereas GluRδ2 selectively cerebellar Purkinje cells. Recently, we found that trans-synaptic interaction of postsynaptic and pre-synaptic neurexins (NRXNs) through cerebellin precursor protein (Cbln) 1 mediates excitatory synapse formation cerebellum. Thus, a question arises whether GluRδ1 regulates forebrain. In this study, showed N-terminal domain induced inhibitory presynaptic differentiation some populations...
Abstract Background The parkin-interacting substrate (PARIS, also known as ZNF746) is a transcriptional repressor, whose accumulation and phosphorylation play central pathological roles in Parkinson’s disease (PD). PARIS-induced repression of PGC-1α or MDM4 contributes to mitochondrial dysfunction p53-dependent neuron loss PD. Despite the important role PARIS PD pathogenesis, unbiased transcriptomic profiles influenced by dopaminergic neurons remain unexplored. Methods We engineered Tet-Off...
Recent preclinical studies show that Neuropilin-1 (NRP1), which is a transmembrane protein with roles in neuronal development, axonal outgrowth, and angiogenesis, also plays role the infectivity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Thus, we hypothesize NRP1 may be upregulated Alzheimer's disease (AD) patients correlation between AD SARS-CoV-2 NRP1-mediated exist as angiotensin converting enzyme (ACE2). We used an mouse model mimics performed high-throughput total...
Exon splicing triggered by unpredicted genetic mutation can cause translational variations in neurodegenerative disorders. In this study, we discover Alzheimer's disease (AD)-specific single-nucleotide variants (SNVs) and abnormal exon of phospholipase c gamma-1 (
Neurodegenerative disorders are caused by neuronal cell death, miscommunications between synapse, and abnormal accumulations of proteins in the brain. Alzheimer’s disease (AD) is one age-related disorders, which most common degenerative today, strongly affects memory consolidation cognitive function Amyloid-β tau triggers for AD pathogenesis, usually used as candidate biomarkers clinical research. Especially, exam, brain imaging molecular biological methods being to diagnosis AD. Genome-wide...
Ginseng leaves are known to contain high concentrations of bioactive compounds, such as ginsenosides, and have potential a treatment for various conditions, including fungal infections, cancer, obesity, oxidative stress, age-related diseases. This study assessed the impact ginseng leaf extract (GLE) on mast cell-mediated allergic inflammation atopic dermatitis (AD) in DNCB-treated mice. GLE reduced skin thickness lymph node nodules suppressed expression secretion histamine pro-inflammatory...
Neurodegenerative diseases result from the interplay of abnormal gene expression and various pathological factors. Therefore, a disease-specific integrative genetic approach is required to understand complexities causes target diseases. Recent studies have identified correlation between genes encoding several transmembrane proteins, such as cluster differentiation (CD) Alzheimer's disease (AD) pathogenesis. In this study, CD48 CD40 in AD, neurodegenerative disease, was analyzed infer link....