A5083212027- Meningioma and schwannoma management
- Head and Neck Surgical Oncology
- Neurofibromatosis and Schwannoma Cases
- Glioma Diagnosis and Treatment
- Facial Nerve Paralysis Treatment and Research
- Vascular Malformations Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Brain Metastases and Treatment
- Spinal Fractures and Fixation Techniques
- Intracranial Aneurysms: Treatment and Complications
- Bone Tumor Diagnosis and Treatments
- Trigeminal Neuralgia and Treatments
- Neurosurgical Procedures and Complications
- Ear and Head Tumors
- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Sinusitis and nasal conditions
- Vestibular and auditory disorders
- Sarcoma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Oral and Maxillofacial Pathology
- Radiomics and Machine Learning in Medical Imaging
- Management of metastatic bone disease
- Reconstructive Facial Surgery Techniques
- Mitochondrial Function and Pathology
The University of Texas Southwestern Medical Center
2016-2025
Neurological Surgery
2015-2024
Southwestern Medical Center
2012-2024
Princeton University
2022
VA North Texas Health Care System
2016
MED-EL (Austria)
2016
Olympus (Germany)
2016
Cochlear (France)
2016
Stryker (United States)
2016
Medtronic (Ireland)
2016
Purpose Proton magnetic resonance spectroscopy (MRS) of the brain can detect 2-hydroxyglutarate (2HG), oncometabolite produced in neoplasms harboring a mutation gene coding for isocitrate dehydrogenase ( IDH). We conducted prospective longitudinal imaging study to determine whether quantitative assessment 2HG by MRS could serve as noninvasive clinical biomarker IDH-mutated gliomas. Patients and Methods was performed 136 patients using point-resolved at 3 T parallel with standard assessment....
Abstract Background Historically, creating patient-derived models of lower-grade glioma (LGG) has been challenging, contributing to few experimental platforms that support laboratory-based investigations this disease. Although organoid modeling approaches have recently employed create in vitro high-grade (HGG), it is unknown whether approach can be successfully applied LGG. Methods In study, we developed an optimized protocol for the establishment organoids from LGG primary tissue samples by...
OBJECTIVE The goal of this study was to analyze the natural history symptomatic brainstem cavernomas (medulla, pons, or midbrain) and outcome after surgical resection. METHODS We retrospectively analyzed clinical data all patients who presented our institution with between 1995 2007 (n = 44). RESULTS After a first neurological event, median event-free interval 2 years, an annual event rate 42%. second (new deficit significant worsening previous deficit), only 5 months, monthly 8%....
Intracranial or brain arteriovenous malformations (BAVMs) are some of the most interesting and challenging lesions treated by cerebrovascular neurosurgeon. It is generally believed that combination BAVMs intracranial aneurysms (IAs) associated with higher hemorrhage rates at presentation rehemorrhage thus a more aggressive course natural history. There wide variation in literature on prevalence BAVM-associated (range 2.7%-58%), 10%-20% being often cited largest case series. The risk patients...
Resection of brainstem cavernous malformations (BSCMs) may reduce the risk stepwise neurological deterioration secondary to hemorrhage, but morbidity surgery remains high. Diffusion tensor imaging (DTI) and diffusion tractography (DTT) are neuroimaging techniques that assist in complex surgical planning necessary for these lesions. The authors evaluate utility preoperative DTI DTT management BSCMs their correlation with functional outcome.A retrospective review was conducted identify...
Introduction: Surgeries for tumors in the cerebellopontine angle (CPA) are challenging, causing deficits hearing, balance, and facial sensation, among others. While previous studies have focused on vestibular schwannomas, there is less data long-term postoperative cranial nerve (CN) outcomes meningiomas, making this one of first retrospective to explore effects surgical clinical characteristics immediate CN CPA meningioma patients.
The incidence of small vestibular schwannomas in patients with serviceable hearing is increasing because the widespread use MRI. middle fossa approach provides patient an opportunity for tumor removal preservation.To determine rate preservation and facial nerve outcomes after a schwannoma approach.A retrospective case review at tertiary, academic medical center was performed identifying from 1998 through 2008 that underwent by approach. Preoperative postoperative audiograms were compared to...
The field of facial paralysis requires the reconstructive surgeon to apply a wide spectrum and aesthetic principles, using comprehensive array surgical tools, including microsurgery, peripheral nerve surgery, surgery on road optimize patient outcomes. distinct deficits created by different anatomical levels injury require fundamental understanding anatomy. Palsy duration, followed location mechanism, will determine mimetic muscle salvageability, means either direct repair, grafting, or...
Anterolateral cavernomas of the pons have been surgically removed via a variety approaches, commonly retrosigmoid or transventricular. The goal in this study was to evaluate presigmoid approach as an alternative.Clinical data were reviewed 9 patients presenting with anterolateral pontine between 1999 and 2007.All treated approach, which provided nearly perpendicular trajectory pons. brainstem entered through "safe zone" trigeminal nerve facial/vestibulocochlear complex. Complete resection...
Patients presenting with trigeminal schwannomas require multimodality management by a skull base surgical team that can offer expertise in both transcranial and transnasal approaches as well radiosurgical microsurgical strategies. Improvement neurologic symptoms, preservation of cranial nerve function, control mass effect are the primary goals for schwannomas. Complete resection is treatment choice but may not be possible all cases. Radiosurgery an option small- to moderate-sized tumors used...
Purpose To test the efficacy of triple‐refocusing MR spectroscopy (MRS) for improved detection 2‐hydroxyglutarate (2HG) in brain tumors at 3T vivo. Methods The sequence parameters were tailored 3T, with density‐matrix simulations and phantom validation, enhancing 2HG 2.25‐ppm signal selectivity respect to adjacent resonances glutamate (Glu), glutamine (Gln), gamma‐aminobutyric acid (GABA). In vivo MRS data acquired from 15 glioma patients analyzed LCModel using calculated basis spectra....
OBJECTIVE A short-term lumbar drain (LD) trial is commonly used to assess the response of normal pressure hydrocephalus (NPH) patients CSF diversion. However, it remains unknown whether predictors passing an LD match improvement after ventriculoperitoneal shunting. The aim this study was examine outcomes, complication rates, and associations between outcomes in with NPH. METHODS authors retrospectively reviewed records 254 probable NPH who underwent March 2008 September 2017. Multivariate...
Objective: To analyze clinical outcomes after treatment of petroclival chondrosarcoma and to propose a novel staging system. Study Design: Retrospective case review, 1995 2015. Setting: Multicenter study. Patients: Consecutive patients with histopathologically proven chondrosarcoma. Intervention(s): Microsurgery, endoscopic endonasal surgery, radiation therapy, observation. Main Outcome Measures: Disease- treatment-associated morbidity, recurrence, mortality. Results: Fifty-five (mean age 42...
Objective: To demonstrate successful surgical management of vestibular schwannomas via an exclusively endoscopic transcanal transpromontorial approach (EETTA). Patients: Four patients with schwannomas. Interventions: Surgical excision EETTA. Main Outcomes: Technique refinements, tumor access, complete removal, and patient morbidity. Results: Three tumors were Koos grade I one was II. All ears had non-serviceable hearing prior to surgery. The EETTA enabled access the internal auditory canal...
Background The etiology of spontaneous cerebrospinal fluid (CSF) rhinorrhea remains unknown, though emerging evidence suggests that this likely represents a variant idiopathic intracranial hypertension. Long-term success rates for repair and postoperative management strategies remain variable. Methods Retrospective review patients undergoing surgical CSF was conducted over 5-year period. Analysis performed to correlate recurrence with demographics perioperative variables. Lumbar puncture...