A5034975422- Head and Neck Cancer Studies
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Head and Neck Surgical Oncology
- Reconstructive Surgery and Microvascular Techniques
- Congenital heart defects research
- Nasal Surgery and Airway Studies
- Lung Cancer Treatments and Mutations
- Gastroesophageal reflux and treatments
- Cardiac tumors and thrombi
- Meningioma and schwannoma management
- Dermatologic Treatments and Research
- Sinusitis and nasal conditions
- Cleft Lip and Palate Research
- Reconstructive Facial Surgery Techniques
- Tracheal and airway disorders
- Facial Nerve Paralysis Treatment and Research
- Viral Infections and Vectors
- Hedgehog Signaling Pathway Studies
- Mosquito-borne diseases and control
- Facial Rejuvenation and Surgery Techniques
- Craniofacial Disorders and Treatments
- Ear Surgery and Otitis Media
- Body Contouring and Surgery
University of South Florida
2006-2022
The University of Texas Southwestern Medical Center
2013-2018
Facial Plastics Surgery Associates
2017
Jacksonville University
2014
Johns Hopkins University
2012-2013
Greater Baltimore Medical Center
2012-2013
Asuragen (United States)
2013
Florida College
2006-2013
University of Florida
2011-2013
Sidney Kimmel Comprehensive Cancer Center
2012
Abstract NOTCH1 mutations have been reported to occur in 10% 15% of head and neck squamous cell carcinomas (HNSCC). To determine the significance these mutations, we embarked upon a comprehensive study NOTCH signaling cohort 44 HNSCC tumors 25 normal mucosal samples through set expression, copy number, methylation, mutation analyses. Copy number increases were identified pathway genes, including ligand JAG1. Gene analysis defined differential expression relative tissues. Analysis individual...
No consensus exists as to the best technique, or techniques, optimize wound healing, decrease pharyngocutaneous fistula formation, and shorten both hospital length of stay time initiation oral intake after salvage laryngectomy. We sought combine recent experience multiple high-volume institutions, with different reconstructive preferences, in management pharyngeal closure technique for post-radiation therapy total laryngectomy an effort bring clarity this clinical challenge.To determine if...
Abstract Purpose: To validate a panel of methylation-based salivary rinse biomarkers (P16, CCNA1, DCC, TIMP3, MGMT, DAPK, and MINT31) previously shown to be independently associated with poor overall survival local recurrence in larger, separate cohort patients head neck squamous cell carcinoma (HNSCC). Experimental Design: One hundred ninety-seven were included. All pretreatment saliva DNA samples evaluated for the methylation status gene promoters by quantitative methylation-specific PCR....
Objective To describe a novel technique for lateral graft tympanoplasty. Study Design Case series with chart review. Setting Tertiary care university hospital. Subjects and Methods Pediatric adult patients tympanic membrane perforations deemed unfavorable medial due to the perforation characteristics or myringitis. Results Between 2014 2016, 34 ears from 31 underwent transcanal endoscopic cartilage The mean age was 24.4 years (range, 6-71 years), 22 (65%) were younger than 18 years. All had...
Objective: To demonstrate successful surgical management of vestibular schwannomas via an exclusively endoscopic transcanal transpromontorial approach (EETTA). Patients: Four patients with schwannomas. Interventions: Surgical excision EETTA. Main Outcomes: Technique refinements, tumor access, complete removal, and patient morbidity. Results: Three tumors were Koos grade I one was II. All ears had non-serviceable hearing prior to surgery. The EETTA enabled access the internal auditory canal...
Antireflux fundoplications are undertaken with hesitation in older patients because of presumed higher morbidity and poorer outcomes. This study was to determine if symptoms gastroesophageal reflux disease (GERD) could be safely abrogated a high-risk/reward population patients. One hundred eight more than 70 years age (range, 70–90 years) underwent laparoscopic Nissen between 1992 2005 were compared 108 concurrent less 60 18–59 relative Before after fundoplication, scored the severity...
Background: Abdominal wound extraction site continues to be a major source of morbidity after laparoscopic-assisted surgery. Methods: A 59-year-old African American woman with past history T3N2M1 colon cancer, who underwent laparoscopic sigmoid colectomy and wedge liver resection (segment IV A) followed by adjuvant chemotherapy was our subject for this study. Twelve months later, she found have positron emission tomography positive lesion 6.5 cm at the left lateral segment. combined...
Background Salivary rinses have been recently proposed as a valuable resource for the development of epigenetic biomarkers detection and monitoring head neck squamous cell carcinoma (HNSCC). Both salivary collected with without an exfoliating brush from patients HNSCC are used in promoter hypermethylation, yet their correlation hypermethylation has not evaluated. This study was to evaluate concordance between HNSCC. Methodolgy 57 paired or identical were evaluated status using Quantitative...
A surgeon faces challenges with cranioplasty techniques to achieve a successful result relatively few complications.To describe unique technique for incorporating both biologic autologous bone and nonbiologic allograft materials defect coverage in favorable outcomes low occurrence of complications.A retrospective medical records review all 26 patients who underwent primary procedure modified between January 2011 December 2015 at high-volume head neck oncologic reconstructive practice was...
<b>Objectives</b> Oncogenic osteomalacia is a paraneoplastic syndrome in which the tumor secretes peptide-like hormone, fibroblast growth factor, resulting urinary loss of phosphates. <b>Methods</b> We present case 50-year-old woman with benign phosphaturic mesenchymal (PMT) involving ethmoid sinus obstruction ostiomeatal complex causing unilateral nasal airway obstruction. <b>Results</b> The was initially thought to be an esthesioneuroblastoma based on primary pathology interpretation and...
The periorbital and forehead regions are among the most expressive parts of face. A thorough understanding complex facial anatomy aesthetic norms essential when evaluating treating a patient for brow rejuvenation. Not only will knowledge enhance injection surgical outcomes, but also diminish potential complications. Combining nonsurgical techniques, including laser skin rejuvenation, can yield natural effective improvements.
This article aims to review the use of giant bilobed flaps in reconstruction various large defects within head and neck. A single case series study with chart was performed. Various facial, neck, mentum were documented, closure accomplished through a variety medially laterally based flaps. Preoperative postoperative photography, as well intraoperative planning, total 23 patients able achieve head, neck single-stage flap. No tissue expanders, free transfers, or skin grafts required final...
Importance: Percutaneous radiofrequency-based skin tightening procedures can offer patients an option to undergo a potential treatment for laxity and excess adipose of the face neck with less downtime, lower cost, decreased risk complications compared more aggressive open such as lift, platysmaplasty. Observations: FaceTite AccuTite safely yet effectively deliver energy into subdermal space, targeting dermal collagen network deeper fascial layer. Ideal candidates have early jowl formation,...
Introduction: Defects of the chin after Mohs resection skin cancer are relatively uncommon yet technically challenging. This is due in part from numerous topographic features and multiple soft-tissue components such as underlying muscle layers, well-defined submental crease, bony gonion, all which contribute to intricacy reconstruction. We review our results over an 11-year period assess most commonly used closure techniques provide a simplified algorithm for defects. Materials Methods:...