A5016193100- Cancer, Hypoxia, and Metabolism
- Renal cell carcinoma treatment
- Biochemical and Molecular Research
- SARS-CoV-2 and COVID-19 Research
- Ferroptosis and cancer prognosis
- Bladder and Urothelial Cancer Treatments
- Cancer Genomics and Diagnostics
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Urologic and reproductive health conditions
- Cancer-related molecular mechanisms research
- Chemical Synthesis and Reactions
- Advanced MRI Techniques and Applications
- Colorectal and Anal Carcinomas
- RNA modifications and cancer
- Organoboron and organosilicon chemistry
- Cancer, Lipids, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Folate and B Vitamins Research
- Genital Health and Disease
- Renal and related cancers
- Parvovirus B19 Infection Studies
- Asymmetric Synthesis and Catalysis
- Cytomegalovirus and herpesvirus research
- Dermatological and COVID-19 studies
University of Virginia
2022-2024
The University of Texas Southwestern Medical Center
2023-2024
Children's Medical Center
2023-2024
Southwestern Medical Center
2024
Children's Medical Center
2023
University of Houston
2021
Most kidney cancers are metabolically dysfunctional
Mitochondria house many metabolic pathways required for homeostasis and growth. To explore how human cells respond to mitochondrial dysfunction, we performed metabolomics in fibroblasts from patients with various disorders cancer electron transport chain (ETC) blockade. These analyses revealed extensive perturbations purine metabolism, stable isotope tracing demonstrated that ETC defects suppress de novo synthesis while enhancing salvage. In lung cancer, tumors markers of low oxidative...
Beyond their pulmonary disease, many COVID-19 patients experience a complex constellation of characteristics, including hyperinflammatory responses, autoimmune disorders, and coagulopathies. However, the pathogenesis these aspects is obscure. More than 90% people are latently infected with lymphotropic herpesviruses Epstein-Barr Virus (EBV) and/or Human Herpesvirus-6 (HHV-6). Some inflammatory features resemble clinical syndromes seen during EBV HHV-6 infection, latent viruses can be...
Summary Most kidney cancers display evidence of metabolic dysfunction 1–4 but how this relates to cancer progression in humans is unknown. We used a multidisciplinary approach infuse 13 C-labeled nutrients during surgical tumour resection over 70 patients with cancer. Labeling from [U- C]glucose varies across subtypes, indicating that the environment alone cannot account for all reprogramming these tumours. Compared adjacent kidney, clear cell renal carcinomas (ccRCC) suppressed labelling...
ABSTRACT Many mechanisms responsible for COVID-19 pathogenesis are well-established, but includes features with unclear pathogenesis, such as autonomic dysregulation, coagulopathies, and high levels of inflammation. The receptor the SARS-CoV-2 spike protein receptor-binding domain (RBD) is angiotensin-converting enzyme 2 (ACE2). We hypothesized that some patients may develop antibodies have a negative molecular image RBD sufficiently similar to ACE2 yield ACE2-like catalytic...
Stable isotopes are powerful tools to assess metabolism.
ABSTRACT Lipids are essential for tumours because of their structural, energetic, and signaling roles. While many cancer cells upregulate lipid synthesis, growing evidence suggests that simultaneously intensify the uptake circulating lipids carried by lipoproteins. Which mechanisms promote extracellular lipids, how this pool contributes to progression, poorly understood. Here, using functional genetic screens, we find lipoprotein confers resistance peroxidation ferroptotic cell death....
SUMMARY Cancer cells reprogram their metabolism to support cell growth and proliferation in harsh environments. While many studies have documented the importance of mitochondrial oxidative phosphorylation (OXPHOS) tumor growth, some cancer experience conditions reduced OXPHOS vivo induce alternative metabolic pathways compensate. To assess how human respond dysfunction, we performed metabolomics fibroblasts plasma from patients with inborn errors metabolism, subjected inhibition electron...
You have accessJournal of UrologyPenile & Testicular Cancer I (MP01)1 May 2024MP01-09 LANDSCAPE OF GENOMIC PROFILING AND CIRCULATING TUMOR DNA AMONG RARE GENITOURINARY CANCERS Austin G. Kazarian, Raj R. Bhanvadia, Thomas S. Gerald, Bailey Brooks, and Vitaly Margulis KazarianAustin Kazarian , BhanvadiaRaj Bhanvadia GeraldThomas Gerald BrooksBailey Brooks MargulisVitaly View All Author Informationhttps://doi.org/10.1097/01.JU.0001008660.87408.90.09AboutPDF ToolsAdd to favoritesDownload...
Abstract Many mechanisms responsible for COVID-19 pathogenesis are well-established, but includes features with unclear pathogenesis, such as autonomic dysregulation, coagulopathies, and high levels of inflammation. The receptor SARS-CoV-2 spike protein’s binding domain (RBD) is angiotensin converting enzyme 2 (ACE2). We hypothesized that some patients may develop antibodies have negative molecular image RBD sufficiently similar to ACE2 yield ACE2-like catalytic activity – abzymes. To...