A5000842663- Laser Applications in Dentistry and Medicine
- Photoacoustic and Ultrasonic Imaging
- Cancer, Hypoxia, and Metabolism
- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Circular RNAs in diseases
- Respiratory Support and Mechanisms
- Bee Products Chemical Analysis
- Electrospun Nanofibers in Biomedical Applications
- Optical Imaging and Spectroscopy Techniques
- Healthcare and Venom Research
- Medical and Biological Ozone Research
- Hydrogen's biological and therapeutic effects
- Cancer-related molecular mechanisms research
- Vitamin C and Antioxidants Research
- Dermatologic Treatments and Research
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Heme Oxygenase-1 and Carbon Monoxide
- Nitric Oxide and Endothelin Effects
- Wound Healing and Treatments
- Spaceflight effects on biology
- Peptidase Inhibition and Analysis
- Neonatal Respiratory Health Research
- Plant nutrient uptake and metabolism
Tiangong University
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2025
State Key Laboratory of Automotive Simulation and Control
2024
Wuhan Polytechnic University
2024
Jilin University
2024
Shanghai Stomatological Hospital
2024
Tongji University
2024
Anhui Academy of Agricultural Sciences
2024
Peking University
2024
Institute of Hematology & Blood Diseases Hospital
2024
Abstract Assembly ubiquitously occurs in nature and gives birth to numerous functional biomaterials sophisticated organisms. In this work, chiral hydrogen-bonded organic-inorganic frameworks (HOIFs) are synthesized via biomimicking the self-assembly process from amino acids proteins. Enjoying homohelical configurations analogous α -helix, HOIFs exhibit remarkable chiroptical activity including fluorescence ( g lum = 1.7 × 10 −3 ) that is untouched among previously reported frameworks....
Abstract Statins are a class of low molecular weight drugs that inhibit the rate-limiting enzyme mevalonate pathway 3-hydroxy-3-methylglutaryl-CoA reductase. have been approved and effectively used to control hypercholesterolemia in clinical setting. Recent study showed statin's antitumor activity suggested potential role for prevention human cancers. In this study, we did cell viability, DNA fragmentation, terminal deoxynucleotidyl transferase–mediated dUTP nick-end labeling assays evaluate...
Mitochondria house many metabolic pathways required for homeostasis and growth. To explore how human cells respond to mitochondrial dysfunction, we performed metabolomics in fibroblasts from patients with various disorders cancer electron transport chain (ETC) blockade. These analyses revealed extensive perturbations purine metabolism, stable isotope tracing demonstrated that ETC defects suppress de novo synthesis while enhancing salvage. In lung cancer, tumors markers of low oxidative...
Abstract Benefit from the deeper penetration of mechanical wave, ultrasound (US)‐based sonodynamic therapy (SDT) executes gratifying efficacy in treating deep‐seated tumors. Nevertheless, complicated mechanism SDT undeniably hinders exploration ingenious sonosensitizers. Herein, a receptor engineering strategy aggregation‐induced emission (AIE) sonosensitizers (TPA‐Tpy) with acceptor (A)‐donor (D)‐A’ structure is proposed, which inspects effect increased cationizations on US sensitivity....
ABSTRACT Neuroinflammation plays a key role in the development of neurodegenerative diseases, with microglia regulating this process through pro‐inflammatory M1 and anti‐inflammatory M2 phenotypes. Studies have shown that human umbilical cord mesenchymal stem cells (hUCMSCs) modulate neuroinflammation by secreting cytokines. Photobiomodulation (PBM), non‐invasive therapy, has demonstrated significant potential alleviating neuroinflammation. This study examines combined effects PBM hUCMSCs an...
The phytohormone auxin is essential for root development in plants. OsMADS25 a homologue of the AGL17-clade MADS-box genes rice. Despite recent progress, molecular mechanisms underlying regulation by are not well known. It unclear whether regulates via signalling. In this study, we examined role and characterized signalling pathway through which system overexpression significantly increased, but RNAi gene silencing repressed primary (PR) length lateral (LR) density. Moreover, promoted LR...
Nicotianamine (NA) plays a crucial role in transporting metal ions, including iron (Fe), plants; therefore, NICOTIANAMINE SYNTHASE (NAS) genes, which control NA synthesis, are tightly regulated at the transcriptional level. However, regulatory mechanisms of NAS genes require further investigations. In this study, we determined bZIP44 mediating plant response to Fe deficiency stress by conducting transformation experiments and assays. positively Arabidopsis interacting with MYB10 MYB72...
MicroRNA-495 (miR-495) is a small non-coding RNA encoded by gene located on chromosome 14 (14q32.31). Its expression regulated the transcription factors EF12 and EF47, in addition to promoter methylation status fusion oncoprotein mixed-lineage leukemia-AF9. Previous studies suggest that miR-495 involved various developmental, immunological inflammatory processes healthy tissue, proliferation, invasion, metastasis drug resistance of cancer cells. The role serves tumors controversial....
Advanced method to solve problems of tumor hypoxia and off-targeting in SDT: (1) transport O 2 through nanocarriers, (2) utilize catalase or nanozymes generate , (3) improve targeting efficiency by modifying coating structure.
Alzheimer's disease (AD) is a neurodegenerative disease. Amyloid β-protein (Aβ) one of the key pathological features AD, which cytotoxic and can damage neurons, thereby causing cognitive dysfunction. Photobiomodulation (PBM) non-invasive physical therapy that induces changes in intrinsic mechanisms cells tissues through low-power light exposure. Although PBM has been employed treatment effect precise mechanism on AD-induced neurological are still unclear. In vivo experiments, (808 nm, 20...
Background Clinical evidence indicates that late acute renal failure (ARF) predicts high mortality in severely burned patients but the pathophysiology of ARF remains undefined. This study was designed to test hypothesis sustained reactive oxygen species (ROS) induced a rat model and investigate signaling mechanisms involved. Materials Methods Rats were exposed 100°C bath for 15 s induce severe burn injury (40% total body surface area). Renal function, ROS generation, tubular necrosis...
Oral squamous cell carcinoma (OSCC) is capable of constructing a favorable immune escape environment through interactions cells with and the environment. Programmed death ligand‑1 (PD‑L1) well‑recognized inhibitor anti‑tumor immunity that plays an important role in tumor escape. However, molecular mechanisms regulating PD‑L1 expression are not yet fully understood. In this study, to investigate protein kinase D3 (PKD3) regulation expression, correlation PKD3 were first analyzed by...
Abstract Oral squamous cell carcinoma (OSCC) has a high incidence of metastasis. Tumour immunotherapy targeting PD-L1 or PD-1 been revolutionary; however, only few patients with OSCC respond to this treatment. Therefore, it is essential gain insights into the molecular mechanisms underlying growth and metastasis OSCC. In study, we analysed expression levels protein kinase D3 (PKD3) their correlation mesenchymal epithelial markers. We found that PKD3 in cells tissues was significantly...
Piwi-interacting RNAs (piRNAs) are a class of non-coding that play key role in spermatogenesis. However, little is known about their expression characterization and somatic cells infected with herpes simplex virus type 1 (HSV-1). In this study, we systematically investigated the cellular piRNA profiles HSV-1-infected human lung fibroblasts. Compared control group, 69 differentially expressed piRNAs were identified infection among which 52 up-regulated 17 down-regulated. The changes 8 further...
Periosteum provides a major source of mesenchymal progenitor cells for bone fracture repair. Combining cell-specific targeted Cox-2 gene deletion approaches with in vitro analyses the differentiation periosteum-derived (PDMPCs), here we demonstrate spatial and temporal role function modulation osteogenic chondrogenic periosteal progenitors Prx1Cre-targeted mesenchyme resulted marked reduction intramembraneous endochondral repair, leading to accumulation poorly differentiated immature...