A5085773409- Hydrogen's biological and therapeutic effects
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Medical and Biological Ozone Research
- Laser Applications in Dentistry and Medicine
- Anesthesia and Neurotoxicity Research
- Silk-based biomaterials and applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Bone Tissue Engineering Materials
- Sirtuins and Resveratrol in Medicine
- Cerebrospinal fluid and hydrocephalus
- Histone Deacetylase Inhibitors Research
- Neurosurgical Procedures and Complications
- Microwave Dielectric Ceramics Synthesis
- Organ Transplantation Techniques and Outcomes
- Phytoestrogen effects and research
- Advanced battery technologies research
- Mesenchymal stem cell research
- RNA modifications and cancer
- Trigeminal Neuralgia and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Nuclear Receptors and Signaling
- Spaceflight effects on biology
Tianjin Beichen Hospital
2018-2025
Tiangong University
2024
South China Agricultural University
2020-2024
Wuhan University of Technology
2022
Tianjin Medical University
2018
Pingjin Hospital
2012-2015
Chinese People's Armed Police Force
2012
ABSTRACT Neuroinflammation plays a key role in the development of neurodegenerative diseases, with microglia regulating this process through pro‐inflammatory M1 and anti‐inflammatory M2 phenotypes. Studies have shown that human umbilical cord mesenchymal stem cells (hUCMSCs) modulate neuroinflammation by secreting cytokines. Photobiomodulation (PBM), non‐invasive therapy, has demonstrated significant potential alleviating neuroinflammation. This study examines combined effects PBM hUCMSCs an...
Genistein, a potent antioxidant compound, protects dopaminergic neurons in mouse model of Parkinson's disease. However, the mechanism underlying this action remains unknown. This study investigated human SH-SY5Y cells overexpressing A53T mutant α-synuclein. Four groups were assayed: control group (without any treatment), genistein (incubated with 20 μM genistein), rotenone (treated 50 rotenone), and + then treated rotenone). A lactate dehydrogenase release test confirmed protective effect...
As a substitute of Pt-based catalysts, MoS2-based catalysts have been widely used in hydrogen evolution reaction, but the inherent low conductivity, limited active edges, self-stacking and agglomeration still hinder their activities. In this work, Mn-doped MoS2 nanosheets were vertically anchored on carbon nanotubes (CNTs) by one-step hydrothermal which Mn-O-C/Mo-O-C was considered as bridge between Mn-MoS2 CNTs. The doping Mn element enables spreading CNTs rapid escape bubbles from...
Background: Malignant glioma is refractory to conventional treatment, highlighting a need develop novel efficacious therapies. Biguanides, class of oral antidiabetic drug, have been thought inhibit proliferation and metastasis in variety cancers. Purpose: The objective this study was investigate the affections biguanides, phenformin (Phen) metformin (Met), on growth migration cells LN229 vitro vivo. Methods: Glioma were treated with Phen or Met, then cell death evaluated by MTT assay PI...
Trigeminocardiac reflex (TCR) is a reflexive response of bradycardia, hypotension and gastric hypermotility which observed upon mechanical stimulation in the distribution trigeminal nerve. Previous articles have described TCR during intracranial operations, ophthalmic surgery, microcompression ganglion radiofrequency lesioning ganglion. may occur transarterial embolization dural arteriovenous fistula (DAVF) with Onyx, leading to significant decrease heart rate under standard anesthetic...
In this study, a novel prefabricated light-steel beam–column connection consisting of thin-walled rectangular hollow section column and two cold-formed steel truss beams is proposed investigated by carrying out experimental tests. Eight cruciform specimens with different configurations are fabricated tested to failure under monotonic static loading. First, mode the loading–displacement curve each specimen investigated. Consequently, effect three variables, including truss-beam configuration,...
To evaluate the effect of umbilical cord derived mesenchymal stem cells (UC-MSCs) transplantation on traumatic brain injury (TBI).UC-MSCs were isolated from human and TBI rat model was constructed. 30 male SD rats randomly divided into 3 groups: control group, group MSCs group. Rats in received injection a total 1.5 Ć- 106 (25 Ī¼l) via ventricle at operated ventricular coordinates (0 bregma, mm lateral, 1.1 behind, 4.5 depth).80% confluence formed tissue day 10 amount CD90, CD73, CD105...
Introduction: Tumor-infiltrating lymphocytes (TILs) therapy is one of the most promising adoptive T cell therapies, which has shown great clinical efficacy against several solid malignancies. Nevertheless, response to TILs mono-therapy in Asian patients with recurrent cervical cancer not been well reported. Case Presentation: Here, we report two who were diagnosed metastatic and tumor progression following multiple conventional treatments. In particular, a history severe myelosuppression...
Background and aim Lymphocytes are effector cells that fight cancer by killing tumor cells. Here, we to explore the prognostic significance of both peripheral tumor-infiltrating lymphocytes (TILs) in newly diagnosed stage III/IV non-small-cell lung (NSCLC). Materials methods In total, 105 cases NSCLC from July 2017 October 2022 at Tianjin Beichen Hospital were retrospectively investigated. Peripheral blood samples time diagnosis tissue slices these patients collected. General cell...
<title>Abstract</title> Neuroinflammation develops in neurodegenerative diseases. The severity of neuroinflammation is closely linked to microglial polarization. Different phenotypes release inflammatory cytokines with distinct functions. Modulation polarization alter a potential therapeutic strategy. Human umbilical cord mesenchymal stem cells (hUCMSCs) possess multiple cell properties that can be used modulate inflammation. Various methods pre-treatment have shown enhanced efficacy disease...
Brain glioma is one of the cancer types with worst prognosis, and LMO2 has been reported to play oncogenic functions in brain gliomas. Herein, analysis datasets from The Cancer Genome Atlas (TCGA) indicated that higher level patient samples worse prognosis lower grade gliomas (LGG) but not glioblastoma multiforme (GBM). Further, tumor tissues consisting a variety cell types, intratumoral endothelium pattern recognition receptor (PRR) response both LGGs GBMs, additionally cytotoxic...
Objective To investigate the safety of application biological artificial dura mater in large decompressive craniectomy for treatment craniocerebral trauma.Methods The incidence complications (intracranial infection,cerebrospinal fluid leak,epilepsy,etc.) and foreign - body reaction after surgery experimental group (330 cases ) was compared with that control (222 cases).Results intracranial leak,epilepsy or other significantly lower than group,while there no statistically significant...
Targeted temperature management (TTM) is referred to as the reducing of core body a specific repair or mitigate tissue damage caused by inadequate blood perfusion.It promising treatment method.However, it widely used in clinical practice, more and disputes have been made about scope effect TTM.This paper will review mechanism TTM, method its implementation application disease, so provide references for further understanding TTM optimizing TTM. Key words: Targeted...
Objective To investigate the effects of resveratrol on formation intracranial aneurysm (IA) and telomere length in rats. Methods Thirty-six SD rats were randomly divided into control group (n=12), IA (n=12) (n=12). Rats used to construct rat model. According dose 40 mg/kg, was dissolved 2 mL saline given intragastrically rats, every day, no additional operation performed group. After 12 weeks, relative expression telomerase reverse transcriptase (TERT) binding protein-tripeptidase 1...