A5051812984- Renal cell carcinoma treatment
- Pancreatic and Hepatic Oncology Research
- Virus-based gene therapy research
- Aortic Disease and Treatment Approaches
- Renal and related cancers
- Thyroid Cancer Diagnosis and Treatment
- CRISPR and Genetic Engineering
- Pancreatitis Pathology and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- MRI in cancer diagnosis
- Ultrasound Imaging and Elastography
- Mitochondrial Function and Pathology
- Ultrasound and Hyperthermia Applications
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- Aortic aneurysm repair treatments
- ATP Synthase and ATPases Research
- Power Systems Fault Detection
- Cancer-related molecular mechanisms research
- Liver physiology and pathology
- Autophagy in Disease and Therapy
- Liver Diseases and Immunity
- Angiogenesis and VEGF in Cancer
- Plant Virus Research Studies
Nanjing University
2014-2024
Nanjing General Hospital of Nanjing Military Command
2013-2024
Xiamen University
2020-2024
China Southern Power Grid (China)
2023
North China University of Science and Technology
2021-2023
Zhejiang University
2013-2021
Second Affiliated Hospital of Zhejiang University
2020-2021
Sir Run Run Shaw Hospital
2021
Blood Center of Zhejiang Province
2014
The clinical importance of intraductal papillary mucinous neoplasms (IPMN) the pancreas has been increasing due to large number newly diagnosed cases. A meta-analysis was used assess accuracy serum carcinoembryonic antigen (CEA) and carbohydrate 19-9 (CA19-9) for identification malignant invasive IPMN. literature search PubMed Web Knowledge conducted. Studies included in analysis addressed diagnostic CEA CA19-9 pooled estimates sensitivity, specificity, positive- negative-likelihood ratios...
Pseudorabies virus (PRV) is a major etiological agent of swine infectious diseases and responsible for significant economic losses in the industry. Recent data points to human viral encephalitis caused by PRV infection, suggesting that may be able overcome species barrier infect humans. To date, there no available therapeutic infection. Here, we report near-atomic structures A-capsid C-capsid, illustrate interaction occurs between these subunits. We show C-capsid portal complex decorated...
C-X-C motif chemokine ligand 14 (CXCL14) is a novel gene that expressed in many normal cells but absent from or at very low levels cancerous tissues such as head and neck squamous cell carcinoma (HNSCC), prostate cancer, pancreatic cancer. However, the relationship between CXCL14 hepatocellular (HCC) remains unclear. Therefore, exact function of CXCL14, which may modulate antitumor immune responses certain cancers, was evaluated. downregulated HCC compared to adjacent tissues. Moreover,...
The mitochondrial GTPase mitofusin-2 (MFN2) gene encodes a membrane protein that can induce apoptosis of hepatocellular carcinoma (HCC) via the apoptotic pathway, as validated in our previous research. However, little is known clinical significance MFN2 expression and its signaling pathways HCC.MFN2 mRNA tumor adjacent non-tumor tissues from 115 patients with HCC was investigated using quantitative real-time PCR. association level pathological parameters evaluated statistically, while...
Abstract Background To investigate the contrast-enhanced ultrasound (CEUS) findings of renal cell carcinoma (RCC) associated with Xp11.2 translocation/TFE3 gene fusion (Xp11.2/TFE3) in adult patients by comparison those clear RCC (ccRCC) and papillary (pRCC). Methods In total, 110 (110 masses) who underwent CEUS examinations were enrolled this study. The cases included 18 Xp11.2/TFE3 RCCs, 60 ccRCCs 32 pRCCs. All masses confirmed operative pathology. imaging data these retrospectively...
Abstract The global incidence rate of kidney cancer (KC) has been steadily increasing over the past 30 years. With aging population, become an escalating concern that necessitates vigilant surveillance. Nowadays, surgical intervention remains optimal therapeutic approach for cancer, while availability efficacious treatments advanced tumors limited. Oncolytic viruses, emerging form immunotherapy, have demonstrated encouraging anti‐neoplastic properties and are progressively garnering public...
Intestinal ultrasound (IUS) is an emerging modality for assessing disease activity, extent, and treatment response in ulcerative colitis. This study aimed to evaluate the potential of IUS predicting severe flares, need rescue therapy (corticosteroid failure), colectomy patients with
Oncolytic viruses are now well recognized as potential immunotherapeutic agents against cancer. However, the first FDA-approved oncolytic herpes simplex virus 1 (HSV-1), T-VEC, showed limited benefits in some patients clinical trials. Thus, identification of novel that can strengthen therapy is warranted. Here, we identified a live-attenuated swine pseudorabies (PRV-LAV) promising agent with broad-spectrum antitumor activity vitro and vivo.PRV cytotoxicity tumor cells normal was tested using...
To describe the clinical, imaging, pathological features and oncologic outcomes of mucinous tubular spindle cell carcinoma (MTSCC) kidney.
Automated breast volume scanner (ABVS) and US elastography (UE) have been useful for the differentiation of benign malignant lesions. However, combining these two methods applied in diagnosis lesions has not yet reported. The aim this study is to analyze inter-examiner reliability ABVS UE, compare diagnostic performance among ABVS, combination methods. Forty-one patients (forty-six lesions) underwent both UE examinations. images were acquired by medial lateral scans each classified a BI-RADS...
// Weilin Wang 1, 2, 3, * , Pengfei Huang Panyisha Wu 3 Rong Kong 1 Jiang Xu Lufei Zhang Qifan Yang Qingsong Xie Linshi 2 Xiaohu Zhou Linghui Chen Haiyang Lin Shusen Zheng Key Lab of Combined Multi-Organ Transplantation, Ministry Public Health, Hangzhou 310003, China Division Hepatobiliary and Pancreatic Surgery, Department First Affiliated Hospital, Zhejiang University School Medicine, Collaborative Innovation Center for Diagnosis Treatment Infectious Diseases, These authors have...
Long noncoding RNAs (lncRNAs) play crucial roles in cancer occurrence and progression. However, the relationship between expression levels of lncRNAs hepatocellular carcinoma (HCC) process is unclear. The goal this study was to determine level ZNF674-AS1, a newly found lncRNA, HCC its clinical association. ZNF674-AS1 137 pairs tumorous adjacent normal tissues from patients with detected by quantitative real-time reverse transcription polymerase chain reaction. Additionally, potential...
Abstract Purpose The purpose of this study was to evaluate the diagnostic performance novel ultrasound technology normalized local variance (NLV) and standard deviation NLV (NLV-SD) using different ROIs for hepatic steatosis in patients with metabolic-associated fatty liver disease (MAFLD) identify factors that influence value NLV-SD value, pathology results as gold standard. Methods We prospectively enrolled 34 consecutive suspected MAFLD who underwent percutaneous biopsy evaluation from...
Seasonal influenza is an acute respiratory infection causing around 500 000 global deaths annually. There unmet medical need to develop more effective antiviral drugs and vaccines against infection. A rapid, accurate, high-throughput titration assay for virus particles or neutralizing antibodies would be extremely useful in these research fields. However, commonly used methods such as tissue culture infective dose plaque-forming units (PFU) particle quantification, the plaque reduction...
To evaluate the effect of umbilical cord derived mesenchymal stem cells (UC-MSCs) transplantation on traumatic brain injury (TBI).UC-MSCs were isolated from human and TBI rat model was constructed. 30 male SD rats randomly divided into 3 groups: control group, group MSCs group. Rats in received injection a total 1.5 Ć- 106 (25 Ī¼l) via ventricle at operated ventricular coordinates (0 bregma, mm lateral, 1.1 behind, 4.5 depth).80% confluence formed tissue day 10 amount CD90, CD73, CD105...
Background: A high rate of glomerulosclerosis serves as an important signal poor response to treatment and a risk disease progression or adverse prognosis in transplanted kidneys. We hypothesized that contrast-enhanced ultrasound (CEUS) could serve novel imaging biomarker the early prediction by evaluating renal allograft microcirculation.
The use of lung ultrasound in the screening, diagnosis, and evaluation interstitial disease has been relatively well studied, but not widely accepted applied clinical practice. There are also some differences examination methods these studies. This paper summarized application, advantages, disadvantages diagnosis follow-up by comprehensively reviewing methods, research results progress new technologies disease.
Abstract Acute Stanford type A aortic dissection (ATAAD) with sudden onset and high mortality requiries a standard Bentall operation accurate prognosis in common, together alteration of CO 2 combining power (CO CP) serum sodium rase concern, hence, we evaluated the prognostic value CP combined ATAAD patients. This retrospective study included 183 patients who underwent for from 2015 to 2021 Fourth Hospital Hebei Medical University, subsequently followed grouping by levels sodium. The...