A5081621577- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Viral-associated cancers and disorders
- Respiratory viral infections research
- COVID-19 and Mental Health
- Virus-based gene therapy research
- Animal Virus Infections Studies
- Immune Cell Function and Interaction
- Respiratory Support and Mechanisms
- Plant Stress Responses and Tolerance
- Cytomegalovirus and herpesvirus research
- Monoclonal and Polyclonal Antibodies Research
- Obstructive Sleep Apnea Research
- Herpesvirus Infections and Treatments
- Parvovirus B19 Infection Studies
- T-cell and B-cell Immunology
- CRISPR and Genetic Engineering
- Pediatric health and respiratory diseases
- Plant responses to elevated CO2
- COVID-19 diagnosis using AI
- Facial Rejuvenation and Surgery Techniques
- SARS-CoV-2 detection and testing
- Posttraumatic Stress Disorder Research
- Viral gastroenteritis research and epidemiology
Sun Yat-sen University
2022-2025
Xiamen University
2014-2024
University of South China
2020-2024
Hunan University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Zhejiang University
2013-2023
Sichuan University
2023
West China Hospital of Sichuan University
2023
Tianjin haihe hospital
2017-2023
Chenzhou First People's Hospital
2020-2023
The emergence of Omicron/BA.1 has brought new challenges to fight against SARS-CoV-2. A large number mutations in the Spike protein suggest that its susceptibility immune protection elicited by existing COVID-19 infection and vaccines may be altered. In this study, we constructed pseudotyped SARS-CoV-2 variant Omicron. sensitivity 28 serum samples from convalescent patients infected with original strain was tested Omicron as well other variants concern (VOCs, Alpha, Beta, Gamma, Delta)...
Aim: To identify the psychological change process of registered nurses who worked in epicenter COVID-19 outbreak.
Abstract Introduction Interleukin (IL)-21 is a member of type I cytokine family. Recent studies indicate that IL-21 can promote T follicular helper (Tfh) cell differentiation and survival, specialized subset which provides help for B cell. It also regulate the activation, proliferation human immunoglobulin (Ig) production as well isotype switching plasma Rheumatoid arthritis (RA) characterized by auto-antibodies overproduction such rheumatoid factor (RF) anti-cyclic citrullinated peptide...
Coronavirus disease 2019 (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)1–3 and individuals COVID-19 have symptoms that can be asymptomatic, mild, moderate or severe4,5. In the early phase of infection, T- B-cell counts are substantially decreased6,7; however, IgM8–11 IgG12–14 detectable within 14 d after symptom onset. COVID-19-convalescent individuals, spike-specific neutralizing antibodies variable3,15,16. No specific drug vaccine...
Abstract Coronavirus disease 2019 (COVID-19) has gained prominence as a global pandemic. Studies have suggested that systemic alterations persist in considerable proportion of COVID-19 patients after hospital discharge. We used proteomic and metabolomic approaches to analyze plasma samples obtained from 30 healthy subjects 54 survivors 6 months discharge the hospital, including non-severe 24 severe patients. Through this analysis, we identified 1019 proteins 1091 metabolites. The...
Plasmonic metasurfaces (PMs) functionalized with the monoclonal antibody (mAb) are promising biophotonic sensors for biomolecular interaction analysis and convenient immunoassay of various biomarkers, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. Previous PM biosensing suffers from slow affinity detection rate lack sufficient studies on SARS-CoV-2 Here, we develop a high-efficiency testing method based label-free mAbs demonstrate their binding characteristics...
We aimed to investigate changes in pulmonary function and computed tomography (CT) findings patients with coronavirus disease 2019 (COVID-19) during the recovery period. COVID-19 underwent symptom assessment, tests, high-resolution chest CT 6 months after discharge from hospital. Of 54 enrolled, 31 23 were moderate severe group, respectively. The main symptoms fatigue exertional dyspnea, experienced by 24.1% 18.5% of patients, respectively, followed smell taste dysfunction (9.3%) cough...
Epstein-Barr virus (EBV) infects more than 90% of the world's adult population and accounts for a significant cancer burden epithelial B cell origins. Glycoprotein (gB) is primary fusogen essential EBV entry into host cells. Here, we isolated two gB-specific neutralizing antibodies, 3A3 3A5; both effectively neutralized dual-tropic infection In humanized mice, antibodies showed effective protection from EBV-induced lymphoproliferative disorders. Cryoelectron microscopy analyses identified...
Background: In this study, we investigated the relationship between serum lactate dehydrogenase (LDH) level and disease progression prognosis of patients with COVID-19. Methods: We retrospectively reviewed information 1,751 COVID-19 from Leishenshan Hospital in Wuhan, China. Univariate multivariate Cox regression analyses as well Logistics analyses, Kaplan-Meier curves were used to determine association LDH levels patients. Results: was an independent risk factor for in-hospital death no...
A miniaturized electronic nose comprised of a detection module and freshness assessment module, was developed for real-time food in refrigerator.
Background Several systemic inflammatory biomarkers have been associated with poor overall survival (OS) and disease severity in patients coronavirus 2019 (COVID-19). However, it remains unclear which markers are better for predicting prognosis, especially COVID-19 Omicron BA.2 infected patients. The present study aimed to identify reliable predictors of prognosis from indicators. Methods A cohort 2645 were retrospectively analyzed during the surge Shanghai between April 12, 2022, June 17,...
Purpose: The purpose of the present study was to estimate effect shionone (SHI) on sepsis-induced acute lung injury (ALI). Methods: cecal ligation and puncture (CLP) surgery performed induce sepsis in mice. Pulmonary hematoxylin eosin staining, wet/dry ratio, myeloperoxidase (MPO) activity, survival rate were detected. RAW264.7 cells treated with SHI stimulated lipopolysaccharide (LPS). also overexpressed by extracellular mechanism protein 1 (ECM1) adenovirus. relative levels...
Long-term humoral immunity to SARS-CoV-2 is essential for preventing reinfection. The production of neutralizing antibody (nAb) and B cell differentiation are tightly regulated by T follicular help (T
Introduction Since December 2019, the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing disease 2019 (COVID-19) has presented considerable public health challenges. Multiple vaccines have been used to induce neutralizing antibodies (nAbs) and memory B-cell responses against viral spike (S) glycoprotein, many essential epitopes defined. Previous reports identified spike-reactive naïve B cells preexisting in unexposed individuals. However, role these...
Epstein-Barr Virus (EBV) as the first characterized tumorigenic virus in humans causes heavy disease burdens. An effective vaccine is urgently needed to block EBV infection. Glycoprotein B (gB) essential fusogen for infection of all susceptible cell types. We previously demonstrated that neutralizing antibody 3A3 targeting gB effectively blocked a humanized mouse model, indicating epitope recognized by potential immunogen candidate. Hence, we rationally designed chimeric virus-like particle...
Outbreaks of an epidemic, such as coronavirus disease 2019 (COVID-19), always brings about far-ranging discrimination and stigmatization to the epicenter. This was a cross-sectional survey conducted assess experienced discrimination, internalized stigma, shame, mental health (anxiety, depression, distress, insomnia) among college students who merely had perceived linkage with COVID-19, explore between negative outcomes through mediating effects shame stigma. A total 995 participants (53%...
Epstein-Barr virus (EBV) is an oncogenic herpesvirus that associated with 200,000 new cases of cancer and 140,000 deaths annually. To date, there are no available vaccines or therapeutics for clinical usage. Recently, the viral heterodimer glycoprotein gH/gL has become a promising target development prophylactic against EBV. Here, we developed anti-gH antibody 6H2 its chimeric version C6H2, which had full neutralizing activity in epithelial cells partial B cells. C6H2 exhibited potent...
Epstein-Barr virus (EBV) is the first reported human oncogenic and infects more than 95% of population worldwide. EBV latent infection in B lymphocytes essential for viral persistence. Glycoprotein gp42 an indispensable member triggering complex entry into cells. The C-type lectin domain (CTLD) plays a key role receptor binding major target neutralizing antibodies. Here, we isolated two rabbit antibodies, 1A7 6G7, targeting CTLD with potent activity against cell infection. Antibody 6G7...
The Epstein-Barr virus (EBV) is the first reported oncogenic herpesvirus that establishes persistent infection in B lymphocytes 95% of adults worldwide. Glycoprotein (gB) plays a predominant role fusion viral envelope with host cell membrane. Hence, it great significance to isolate gB-specific fusion-inhibiting neutralizing antibodies (NAbs). AMMO5 only gB NAb but fails antagonize B-cell infection. It essential potent NAbs can completely block EBV cells. Using hybridoma technology and...
The COVID-19 pandemic has taken a significant toll on people worldwide for more than 2 years. Previous studies have highlighted the negative effects of mental health healthcare workers (HCWs) positive changes, such as post-traumatic growth (PTG). Furthermore, most previous were cross-sectional surveys without follow-ups. This study draws PTG follow-up during outbreak at 12-month intervals years since 2020. trajectories and baseline predictors described.A convenience sampling method was used...