A5100747604- Plant Stress Responses and Tolerance
- Gut microbiota and health
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Radiomics and Machine Learning in Medical Imaging
- Tea Polyphenols and Effects
- Cancer-related molecular mechanisms research
- Vitamin K Research Studies
- Plant biochemistry and biosynthesis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Antibiotic Resistance in Bacteria
- Plant Micronutrient Interactions and Effects
- Plant Molecular Biology Research
- Plant responses to water stress
- Cancer Mechanisms and Therapy
- Redox biology and oxidative stress
- Plant Surface Properties and Treatments
- Mechanisms of cancer metastasis
- Enzyme function and inhibition
- Psidium guajava Extracts and Applications
- Inflammatory Biomarkers in Disease Prognosis
- Ginger and Zingiberaceae research
- Aldose Reductase and Taurine
- Bioactive natural compounds
Cangzhou Central Hospital
2025
Chinese People's Liberation Army
2025
ZheJiang Academy of Agricultural Sciences
2020-2024
Hebei Medical University
2024
People's Hospital of Cangzhou
2019-2023
Zunyi Medical University
2009-2021
Sericultural Research Institute
2018
Lung cancer has high incidence and mortality rates worldwide. In the present study, mechanisms by which hesperidin decreases viability induces apoptosis of human non-small cell lung (NSCLC) A549 cells were investigated. Initially, MTT flow cytometric assays performed to evaluate effects on normal epithelial BEAS-2B cells. The results revealed that no negative treated with various concentrations was inhibited in a time- dose-dependent manner compared control groups. Subsequently, expression...
Sciadonic acid (SA) could alleviate obesity and its related metabolic disorders. SA altered the gut microbial structure composition in obese mice. ameliorated lipid metabolism disorders by activating PPARα/SREBP-1C/FAS pathway.
<title>Abstract</title> Extensive-stage small cell lung cancer (ES-SCLC) is a highly aggressive subtype of with limited treatment options and poor prognosis. In recent years, immune checkpoint inhibitors (ICIs) combined chemotherapy have demonstrated significant efficacy in several clinical trials. This study aims to evaluate the first-line immunotherapy ES-SCLC patients identify prognostic factors based on real-world data. retrospective analyzed data 349 treated at Cangzhou Hospital...
Macrophages produce a large volume of ROS (reactive oxygen species) through respiratory burst. However, the influence iNOS [inducible NOS (nitric oxide synthase)] activation on production remains unclear. In present study, kinetic generation in RAW264.7 murine macrophages was monitored by chemiluminescence. PMA induces robust chemiluminescence cells, suggesting PKC (protein kinase C)-related assembly and NOX (NADPH oxidase). The effects induction were examined. Induction expression cells...
Arabidopsis thaliana AKR2A plays an important role in plant responses to cold stress. However, its exact function resistance stress remains unclear. In the present study, we found that contents of very long-chain fatty acids (VLCFAs) akr2a mutants were decreased, and expression level KCS1 was also reduced. Overexpression could enhance VLCFAs chilling tolerance. Yeast-2-hybrid bimolecular fluorescence complementation (BIFC) results showed transmembrane motif interacts with PEST both vitro...
Upregulation of the six-transmembrane epithelial antigen prostate-1 (STEAP1) is closely associated with prognosis numerous malignant cancers. However, its role in lung adenocarcinoma (LUAD), most common type cancer, remains unknown. This study aimed to investigate STEAP1 occurrence and progression LUAD potential mechanisms underlying regulatory effects.STEAP1 mRNA protein expression were analyzed 40 patients via real-time PCR western blotting, respectively. We accessed clinical data 522 from...
Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by hyperglycemia. The aim of this work was to investigate the effect sciadonic acid (SA) on disorders glucolipid metabolism and intestinal flora imbalance further its potential molecular mechanism anti-diabetes. experimental data indicated that SA could alleviate hyperlipidemia, insulin resistance, oxidative stress, inflammatory response, repair liver function damage, promote glycogen synthesis caused T2DM. also activate...
Colitis is characterized by colonic inflammation and impaired gut health, alterations in the microbiota may lead to development of inflammatory bowel disease (IBD). Camellia oil (CO) possesses high nutritional value offers various health benefits for human metabolic disorders diseases. However, it unclear whether CO ameliorates IBD plays a role microbiota. This study aimed investigate effect on using mice model dextran sodium sulfate (Dss)-induced ulcerative colitis (UC). Our findings...
Abstract BACKGROUND Cyclophosphamide (Cy) is a frequently used chemotherapeutic drug, but long‐term Cy treatment can cause immunosuppression and intestinal mucosal damage. The barrier gut flora play important roles in regulating host metabolism, maintaining physiological functions protecting immune homeostasis. Dysbiosis of the affects development microenvironment, as well various external systemic diseases metabolic syndrome. RESULTS present study investigated influence sciadonic acid (SA)...
High-fat diet (HFD) has been associated with certain negative bone-related outcomes, such as bone metabolism disruption and loss.
Summary The biosynthesis of very‐long‐chain fatty acids (VLCFAs) and their transport are required for fibre development. However, whether other regulatory factors involved in this process is unknown. We report here that overexpression an Arabidopsis gene ankyrin repeat‐containing protein 2A ( AKR2A ) cotton promotes elongation. RNA‐Seq analysis was employed to elucidate the mechanisms regulating VLCFA content ratio VLCFAs short‐chain increased transgenic lines. In addition, elongation by...
The present study aims to investigate the therapeutic value of third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) combined with cranial radiotherapy (RT) in patients EGFR-positive non-small cell lung cancer (NSCLC) and brain metastases (BMs). Methodology This is a retrospective that involved 213 EGFR-NSCLC BMs, divided into two groups: upfront RT (ucRT) group (n = 96) non-ucRT 117). All were administered osimertinib, those ucRT also underwent RT....
The expression of progestin and adipoQ receptor 3 (PAQR3) is generally downregulated in multiple tumors, which associated with tumor progression poor prognosis. clinical value PAQR3 was analyzed using various databases 60 patients non-small cell lung cancer (NSCLC). In addition, counting kit-8 (CCK-8), colony formation, flow cytometry assays were used to evaluate the effect on growth NSCLC cells vitro. Gene set enrichment analysis (GSEA) performed investigate possible mechanism through...
Ricinus communis displays a broad range of phenotypic diversity in size, with dwarf, common, and large-sized varieties. To better understand the differences plant productivity between high-stalk variety dwarf under normal growth conditions, we carried out comparative proteomic study Zhebi 100 (a high stalk variety) 26 combined agronomic physiological analyses. Over 1000 proteins were detected, 38 which differed significantly two varieties identified by mass spectrometry. Compared 100, found...
Olive suffers from cold damage when introduced to high-latitude regions its native warm climes. Therefore, this study aims improve the adaption of olive climates in which it is for part year. The phenotype, physiological performance, nutrient content, and gene expression leaves (from two widely planted cultivars) were examined after cultivation normal stress conditions. results showed that cold-tolerant cultivar possessed stronger photosynthesis efficiency higher anti-oxidase activity...
A single carbapenem-resistant, hypervirulent Klebsiella pneumoniae strain has attracted major public concern. The aim of the present study was to better understand antimicrobial resistance and genetic characteristics XJ-K1. XJ-K1 isolated from a urine specimen 69-year-old male patient in teaching hospital Shanghai, China, January 2018. Antimicrobial susceptibility testing, string test, whole-genome sequencing, bioinformatics analysis phylogenetic were performed this study. an extensively...
In prior investigations, a correlation was established between patient outcomes in locally advanced non-small cell lung cancer (LA-NSCLC) following thoracic irradiation and parameters, such as pre/post-treatment neutrophil-to-lymphocyte ratio (NLR) NLR change (ΔNLR). However, these parameters could potentially be influenced by radiation-related variables, gross tumor volume (GTV). The primary aim of this study to elucidate the factors impacting post-treatment ΔNLR further assess their...
Obesity has become one of the most serious chronic diseases threatening human health. Its onset and progression are closely related to intestinal microbiota, as disruption flora promotes production endotoxins induces an inflammatory response. This study aimed investigate variations in physicochemical properties various refined tea seed oils their impact on microbiota disorders induced by a high-fat diet (HFD) through dietary intervention. In present study, C57BL/6J mice HFD were randomly...
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Chilling is common in nature and can damage most plant species, particularly young leaves buds. Mulberry (Morus spp.) an economically important food source for the domesticated silkworm (Bombyx mori). However, weather climatic extremes, such as "late spring coldness", seriously mulberry buds leaves. The molecular mechanism involved differing chilling tolerance unclear. In present study, we found that mSOD1, mFADII, mKCS1 interacted with mAKR2A expression of mAKR2A, mSOD, mFAD,...
As one of the serious environmental problems worldwide, acid rain (AR) has always caused continuous damage to forestry ecosystem. Studies have shown that AR can leach calcium ions from plants and soil. Calcium (Ca) is also a crucial regulator plant stress response, whereas there are few reports on how Ca regulates response AR-resistant woody stress. In this study, by setting different exogenous levels, we study physiological molecular mechanism in regulating Taxus wallichiana var. mairei Our...