A5057403645- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- CAR-T cell therapy research
- Helminth infection and control
- Virus-based gene therapy research
- Cancer-related molecular mechanisms research
- Viral Infectious Diseases and Gene Expression in Insects
- Liver Disease Diagnosis and Treatment
- DNA Repair Mechanisms
- Parasitic infections in humans and animals
- MicroRNA in disease regulation
- Parasitic Infections and Diagnostics
- Biosimilars and Bioanalytical Methods
- Immune Cell Function and Interaction
- Carcinogens and Genotoxicity Assessment
- Adsorption and biosorption for pollutant removal
- Genomics and Phylogenetic Studies
- Amoebic Infections and Treatments
- Biomedical Ethics and Regulation
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Neural Networks and Reservoir Computing
- Malaria Research and Control
- Freshwater macroinvertebrate diversity and ecology
- Phytochemical compounds biological activities
South China Agricultural University
2018-2025
First Affiliated Hospital Zhejiang University
2021-2024
Zhejiang University
2015-2024
Cell Technology (China)
2024
Hainan Medical University
2024
Nanjing Tech University
2023
Shanghai Jiao Tong University
2022
Ningxia Medical University
2022
Central South University
2013-2022
Huaibei Normal University
2022
Chimeric antigen receptor (CAR)-T therapy has shown superior efficacy against hematopoietic malignancies. However, many patients failed to achieve sustainable tumor control partially due CAR-T cell exhaustion and limited persistence. In this study, by performing single-cell multi-omics data analysis on patient-derived cells, we identify CD38 as a potential hallmark of exhausted which is positively correlated with exhaustion-related transcription factors further confirmed in vitro models....
Glutathione depletion and 12-lipoxygenase-dependent metabolism of arachidonic acid are known to be implicated in neurodegeneration associated with acute ischemic stroke. The objective this study was investigate the significance miR-29 Neural cell death caused by insult glutathione-deficient cells preceded a loss miR-29b. Delivery miR-29b mimic blunt such neuroprotective. inhibition potentiated neural death. 12-Lipoxygenase knockdown inhibitors attenuated challenged cells. In vivo, stroke...
Abstract Circular RNAs (circRNAs) have been shown to play critical roles in cancer biology, but their functions nonalcoholic steatohepatitis (NASH) remain unexplored. Full length of circRNA_002581 was amplified and sequenced, followed by RNA immunoprecipitation, RNA-Fluorescence Situ Hybridization dual luciferase reporter gene analysis confirm the existence circRNA_002581–miR-122–CPEB1 regulatory axis vitro. CircRNA_002581 knockdown used study its high concentration free fatty acids-induced...
Chimeric antigen receptor (CAR) T cells are potent agents for recognizing and eliminating tumors, have achieved remarkable success in the treatment of patients with refractory leukemia lymphoma. However, dysfunction cells, including exhaustion, is an inevitable obstacle persistent curative effects. Here, authors initially found that calcium signaling hyperactivated via sustained tonic CAR-T cells. Next, it revealed store-operated entry (SOCE) inhibitor BTP-2, but not chelator BAPTA-AM,...
The repeated appearance of strikingly similar crab–like forms in independent decapod crustacean lineages represents a remarkable case parallel evolution. Uncertainty surrounding the phylogenetic relationships among has hampered evolutionary studies. As is often case, aligned DNA sequences by themselves were unable to fully resolve these relationships. Four nested mitochondrial gene rearrangements–including one few reported movements an arthropod protein–coding gene–are congruent with...
miR-199a-5p plays a critical role in controlling cardiomyocyte survival. However, its significance endothelial cell biology remains ambiguous. Here, we report the first evidence that negatively regulates angiogenic responses by directly targeting v-ets erythroblastosis virus E26 oncogene homolog 1 (Ets-1). Induction of human dermal microvascular cells (HMECs) blocked response Matrigel® culture, whereas miR-199a-5p-deprived exhibited enhanced angiogenesis vitro. Bioinformatics prediction and...
Background The determinants of differences in host infectivity among Cryptosporidium species and subtypes are poorly understood. Results from recent comparative genomic studies suggest that gains losses multicopy subtelomeric genes encoding insulinase-like proteases (INS-19 INS-20 parvum their orthologs closely related species) may potentially contribute to these differences. Methodology/Principal findings In this study, we investigated the expression biological function INS-19 C ....
Abstract The success of chimeric antigen receptor (CAR) T cells in treating B cell malignancies comes at the price eradicating normal cells. Even though are aggressive and treatment options limited, similar strategies for constrained by severe immune suppression arising from bystander aplasia. Here, we show selective killing malignant without affecting cell-mediated responses vitro a mouse model disseminated leukemia. Further, develop CAR construct that carries single chain variable fragment...
The CAR T-cell therapy is a promising approach to treating hematologic malignancies. However, the application in solid tumors still has many tough challenges, including heterogenicity antigen expressions and immunosuppressive tumor microenvironment (TME). As new cancer treatment modality, oncolytic virotherapy can be engineered circumvent these obstacles for T cell tumors.In this study, an oHSV T7011 drive ectopic expression of dual-antigens, extracellular domains CD19 BCMA, on surface...
<b><i>Background:</i></b> Chimeric antigen receptor (CAR)-T cell therapy represents a significant advancement in the field of immunotherapy, providing targeted eradication abnormal cells through recognition between CAR and target antigens. This approach has garnered considerable attention due to its promising results clinical treatment hematological malignancies autoimmune diseases. As focus shifts toward exploring novel targets expanding application CAR-T solid...
Abstract Humic acid (HA) is used as one of organic active fractions a new binder in the process iron ore agglomeration. The purpose this study was to determine detailed adsorption characteristics HA onto particles. results demonstrated that strongly dependent on solution pH, concentration, contact time and temperature. chemical controlled particles typically found earlier reported results. kinetics at different testing conditions well described by first-order model, which indicated rate...
Activating transcription factor 6 (ATF6) and receptor-interacting protein 3 (RIP3) are important signaling proteins in endoplasmic reticulum (ER) stress necroptosis, respectively. However, their regulatory relationship clinical significance unknown. We investigate the impact of ATF6 on RIP3 expression, its role hepatocyte necroptosis an acute liver injury model.In vivo vitro experiments were carried out. LO2 cells treated with thapsigargin (TG). In vivo, male BALB/c mice carbon tetrachloride...
Abstract Dipetalonema gracile is a common parasite in squirrel monkeys ( Saimiri sciureus ), which can cause malnutrition and progressive wasting of the host, lead to death case massive infection. This study aimed identify suspected D. worm from dead monkey by means molecular biology, amplify its complete mitochondrial genome polymerase chain reaction (PCR) sequence analysis. The results identified as , full length was 13,584 bp, contained 22 tRNA genes, 12 protein-coding two rRNA one...