A5085266820- Oceanographic and Atmospheric Processes
- Arctic and Antarctic ice dynamics
- Marine and coastal ecosystems
- Cryospheric studies and observations
- Climate variability and models
- Geology and Paleoclimatology Research
- Ocean Waves and Remote Sensing
- Methane Hydrates and Related Phenomena
- Atmospheric and Environmental Gas Dynamics
- RNA modifications and cancer
- Isotope Analysis in Ecology
- Marine and fisheries research
- Tropical and Extratropical Cyclones Research
- Viral Infections and Vectors
- Microbial Community Ecology and Physiology
- Marine Biology and Ecology Research
- Mercury impact and mitigation studies
- CAR-T cell therapy research
- Viral Infections and Outbreaks Research
- Epigenetics and DNA Methylation
- Particle Detector Development and Performance
- Climate change and permafrost
- interferon and immune responses
- RNA regulation and disease
- IL-33, ST2, and ILC Pathways
Shanghai Jiao Tong University
2014-2025
Polar Research Institute of China
2022-2025
Zhejiang University
2018-2025
Ministry of Natural Resources
2022-2025
First Affiliated Hospital Zhejiang University
2022-2024
Cell Technology (China)
2024
Chaohu Hospital of Anhui Medical University
2016-2024
Institute of High Energy Physics
2019-2024
Chinese Academy of Sciences
2024
State Key Laboratory of Satellite Ocean Environment Dynamics
2022
Global and regional ocean sea ice reanalysis products (ORAs) are increasingly used in polar research, but their quality remains to be systematically assessed. To address this, the Polar ORA Intercomparison Project (Polar ORA-IP) has been established following on from ORA-IP project. Several aspects of ten selected ORAs Arctic Antarctic were addressed by concentrating comparing mean states terms snow, ice, transports hydrography. Most diagnostics carried out for first time such an extensive...
Abstract Microplastics (MPs) are contaminants ubiquitously found in the global biosphere that enter body through inhalation or ingestion, posing significant risks to human health. Recent studies emerge MPs present bone marrow and damage hematopoietic system. However, it remains largely elusive about specific mechanisms by which affect stem cells (HSCs) their clinical relevance HSC transplantation (HSCT). Here, we established a long-term intake mouse model caused severe Oral gavage...
Chimeric antigen receptor (CAR)-T therapy has shown superior efficacy against hematopoietic malignancies. However, many patients failed to achieve sustainable tumor control partially due CAR-T cell exhaustion and limited persistence. In this study, by performing single-cell multi-omics data analysis on patient-derived cells, we identify CD38 as a potential hallmark of exhausted which is positively correlated with exhaustion-related transcription factors further confirmed in vitro models....
The discovery of the Higgs boson with its mass around 125 GeV by ATLAS and CMS Collaborations marked beginning a new era in high energy physics. will be subject extensive studies ongoing LHC program. At same time, lepton collider based factories have been proposed as possible next step beyond LHC, main goal to precisely measure properties probe potential physics associated boson. Circular Electron Positron Collider~(CEPC) is one such factories. CEPC an $e^+e^-$ circular hosted China. Located...
Abstract The northern Antarctic Peninsula (NAP) region is a highly productive ecosystem that supports large krill‐based food web. In summer 2006, the NAP had substantially elevated phytoplankton biomass, with surface chlorophyll‐a concentrations reached greatest level during 2001–2023. Using long‐term in situ data from U.S. Marine Living Resources program, satellite observations, and ERA5 reanalysis products, mechanisms of anomalies 2006 were analyzed. results suggest position Amundsen Sea...
Adult hematopoietic stem cells (HSCs) homeostasis is critically important in maintaining lifelong hematopoiesis. However, how adult HSCs orchestrate its remains not fully understood. Imprinted gene Dlk1 has been shown to play critical role mouse embryonic hematopoiesis and regulation of cells, but physiological roles are unknown.We performed expression analysis Dlk1, constructed conditional knockout (KO) mice by crossing Mx1 cre with Dlkflox/flox mice. Western blot quantitative PCR were used...
Chronic hepatitis B (CHB) is caused by HBV infection and affects the lives of millions people worldwide causing liver inflammation, cirrhosis, cancer. Interferon-alpha (IFN-α) therapy a conventional immunotherapy that has been widely used in CHB treatment achieved promising therapeutic outcomes activating viral sensors interferon-stimulated genes (ISGs) suppressed HBV. However, longitudinal landscape immune cells patients effect IFN-α on system are not fully understood.
Abstract Frontal processes play a significant role in estuarine and coastal ecosystem dynamics. In this study, hydrodynamic model of the Changjiang River plume was developed based on Regional Ocean Modeling System, Lagrangian Coherent Structures (LCSs) were applied to simulations analyze horizontal transport characteristics river with surface front, tidal far‐field front summer. The results show that currents during ebb tide supercritical upstream near‐field subcritical downstream fronts....
Abstract The Pearl River plays an important role in transporting terrestrial organic carbon (OC) to the South China Sea (SCS). However, sources and compositional distribution of OC system are poorly understood. This study focused on delineating determining fate surface sedimentary from Feilaixia Hydropower Station coastal SCS. Elemental, stable carbon/nitrogen isotope (δ 13 C δ 15 N), lignin‐phenol analyses have been conducted. total (TOC) upstream sites were generally derived vascular...
Intrusions of the warm and nutrient-rich Circumpolar Deep Water (CDW) across Ross Sea shelf break play an important role in providing heat for ice basal melting setting physical environment biochemical processes. Several mechanisms driving CDW intrusions into were proposed such as mesoscale eddies, tidal rectification, interactions between Antarctic Slope Current (ASC) topographic features. The seasonal variations poleward transport are investigated using ERA-Interim wind data a circulation...
Abstract. High-salinity shelf water (HSSW) acts as a precursor to the Antarctic Bottom Water (AABW) and plays critical role in regulating global ocean circulation system. This study employs high-resolution coupled ocean-sea ice-ice model analyze interannual variation HSSW formation Ross Sea, which is one of major production sites HSSW. We are particularly focused on anomalously high during winter 2007. The results indicate that this winter, there were frequent passages synoptic-scale...
Abstract. The Ross Sea in the Southern Ocean is a key region for formation of Antarctic Bottom Water (AABW) that supplies lower limb global overturning circulation and contributes to 20 %–40 % total AABW production. primarily originates from polynyas characterized by strong sea ice production ocean convection lead Dense Shelf (DSW), precursor AABW. characteristics DSW surrounding are significantly affected shelf meltwater transported nearby Amundsen Sea. scarcity long-term observations...
Abstract The Ross Sea in the Southern Ocean is a key region for Antarctic Bottom Water (AABW) production, primarily originating from Dense Shelf (DSW) formed polynyas. Here we project future changes DSW and AABW production using high‐resolution ocean‐sea ice‐ice shelf coupled model that can well capture observed temporal variability, forced by projected atmospheric perturbations CMIP6 multi‐model mean results. Under high‐emissions scenario, volume of will decrease ∼26% 2051–2060 ∼51%...
Ocean frontal regions are pivotal for physical and biogeochemical processes, particularly in estuarine coastal regions, where their dynamic processes often associated with high-frequency phytoplankton blooms. In strongly tidal the horizontal divergence is significantly regulated by forcing. this study, a high-resolution hydrodynamic model based on Regional Modeling System was utilized to investigate seasonal, spring-neap tides, high-low water slack characteristics of Changjiang River plume...