A5100682884- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Vector-Borne Animal Diseases
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- Ubiquitin and proteasome pathways
- Phytochemistry and Biological Activities
- Insect symbiosis and bacterial influences
- Natural product bioactivities and synthesis
- Plant Virus Research Studies
- Phytochemistry and Bioactive Compounds
- Plant Molecular Biology Research
- Lipid metabolism and disorders
- Dialysis and Renal Disease Management
- T-cell and B-cell Immunology
- Viral-associated cancers and disorders
- Glycosylation and Glycoproteins Research
- Chronic Kidney Disease and Diabetes
- Plant Stress Responses and Tolerance
- Glioma Diagnosis and Treatment
- Land Use and Ecosystem Services
First Affiliated Hospital of Jiangxi Medical College
2022-2024
Credo Reference (United States)
2024
Weatherford College
2024
Institute of Botany
2014-2023
Zhejiang University
2023
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2023
Qingdao University
2011-2023
Jiangxi Provincial People's Hospital
2022-2023
National Clinical Research Center for Digestive Diseases
2023
Nanjing University of Posts and Telecommunications
2023
While immune checkpoint blockade leads to potent antitumor efficacy, it also immune-related adverse events in cancer patients. These toxicities stem from systemic activation resulting inflammation of multiple organs, including the gastrointestinal tract, lung, and endocrine organs. We developed a dual variable domain immunoglobulin anti-CTLA4 antibody (anti-CTLA4 DVD, where CTLA4 is defined as cytotoxic T lymphocyte–associated antigen-4) possessing an outer tumor-specific antigen-binding...
Progressive proteinuria is one of the earliest clinical features diabetic nephropathy (DN). In our previous study, lncRNA DLX6-AS1 (DLX6-AS1, Dlx6os1 in mouse) was found to be associated with extent albuminuria DN patients. Furthermore, lack pivotal switching off inflammatory response db/db mouse model. However, regulatory factors responsible for elevated remains unknown.To identify potential DLX6-AS1, JASPAR database and DNA pull down combined subsequent liquid chromatography-tandem mass...
Chronic hepatitis B (CHB) is caused by HBV infection and affects the lives of millions people worldwide causing liver inflammation, cirrhosis, cancer. Interferon-alpha (IFN-α) therapy a conventional immunotherapy that has been widely used in CHB treatment achieved promising therapeutic outcomes activating viral sensors interferon-stimulated genes (ISGs) suppressed HBV. However, longitudinal landscape immune cells patients effect IFN-α on system are not fully understood.
Japanese encephalitis (JE) is very prevalent in China, but the incidence of JE among children has been greatly reduced by extensive promotion vaccinations. The adults, however, increased some parts China.Data on mainland terms incidence, gender, and age, were collected between 2004 2014. We conducted spatial temporal analyses data from different age groups. Generally, aged 0-15 years still represent major population cases despite gradual decrease over years. However, adults several provinces...
Extracellular vesicles (EVs), which are small secreted by various cells, have been proven to play a significant role in the progression of multiple diseases, including sclerosis (MS). This study explores potential regulatory mechanisms EVs MS and their as carriers cytokines such TNF-α IL-6. Through numerical simulations experimental methods, we investigated impact cytokine cargo concentrations on immune responses neuroinflammation. The results from indicate that not only serve for but also...
Alternative strategies for vaccination against influenza that elicit both systemic antibody and mucosal IgA responses are needed to improve the efficacy in protection infection. This study demonstrated oral delivery of inactivated vaccine with heat-labile enterotoxin (LT) from enterotoxigenic Escherichia coli elicited spectrum humoral cell-mediated BALB/c mice critical recovery virus Coadministration LT increased antiviral serum IgG compared administration alone. Serum...
Abstract We isolated 17 viral strains capable of causing cytopathic effects in mammalian cells and death neonatal mice from sand flies China. Phylogenetic analysis showed that these belonged to the genus Phlebovirus. These findings highlight need control this potentially emerging virus help safeguard public health.
The cultivated strawberry (Fragaria × ananassa), an allo-octoploid with non-climacteric fleshy fruits, is a popular Rosaceae horticultural crop worldwide that mainly propagated via stolons during cultivation. Woodland vesca), one of the four diploid progenitor species strawberry, widely used as model plant in study fruit trees, fruits and stolons. One GRAS transcription factor has been shown to regulate stolon formation; other proteins woodland remain unknown. In this study, we identified 54...
The mechanism underlying epithelial‑to‑mesenchymal transition (EMT) caused by high glucose (HG) stimulation in diabetic nephropathy (DN) remains to be fully elucidated. present study investigated the effects of HG on EMT and activity glycogen synthase kinase 3β (GSK‑3β) podocytes kidneys db/db mice, assessed (2'Z, 3'E)‑6‑bromoindirubin‑3'‑oxime (BIO), an inhibitor GSK‑3β, glomerular injury. resulting data showed that GSK‑3β was upregulated downregulated BIO renal cortex. expression levels...
Inhibiting ErbB2 signaling with monoclonal antibodies (mAbs) or small molecules is an established therapeutic strategy in oncology. We have developed anti-ErbB2 Dual Variable Domain Immunoglobulin (DVD-Ig) proteins that capture the function of a combination two antibodies. In addition, some DVD-Ig gain new functions enhancing and cell proliferation N87 cells. further found proteins, DVD687 DVD688, distinct mechanisms actions Calu-3 enhances cycle progression while DVD688 induces apoptosis...
Two new phthalides, chuanxiongdiolides A and B, were isolated from the roots of Ligusticum chuanxiong Hort. Their structures established by UV, IR, 1D (¹H, ¹³C) 2D (HSQC, ¹H-¹H COSY, HMBC, NOESY) NMR, HR-ESI-MS methods, their absolute configurations assigned via circular dichroism exciton chirality. The two compounds showed different degrees inhibitory effects against butyrylcholine esterase.
Between 1% and 15% of people are globally affected by kidney stones, this disease has become more common since the 1970s. Therefore, study aims to investigate effects gastrin‐releasing peptide receptor (GRPR) gene silencing via PI3K/Akt signaling pathway on development epithelial–mesenchymal transition (EMT) formation a calcium oxalate crystal in renal tubular epithelial cells (TECs) stones. A total 70 clean healthy C57BL/6J mice were assigned into normal ( n = 10) stones groups 60). The...
BACKGROUND Angiopoietin-like proteins (ANGPTL) are a family of secretory glycoproteins that involved in many pathophysiological processes. ANGPTL7 is newly-discovered member the ANGPTL and plays role corneal morphogenesis, angiogenesis, glaucoma, cancer. To date, whether osteoporosis unknown. Therefore, to discover effects on osteoporosis, we explored expression preosteoblasts assessed mechanism underlying its proliferation differentiation abilities preosteoblasts. MATERIAL AND METHODS Mouse...
Background Chronic renal failure (CRF) has become a major public health concern, which increases the risk of stroke and systemic thromboembolism. Therefore, therapeutic strategies are in urgent requirement. This study was conducted for investigating efficacy hemodialysis (HD), hemodiafiltration (HDF), hemoperfusion (HP) patients with CRF correlation presence complications following HD therapy. Methods The effect, living quality, biochemical indicators, dry weight were detected before after...