A5061460296- Immune Cell Function and Interaction
- HIV Research and Treatment
- Rheumatoid Arthritis Research and Therapies
- Immunotherapy and Immune Responses
- Spondyloarthritis Studies and Treatments
- Cancer Immunotherapy and Biomarkers
- Multiple Sclerosis Research Studies
- Melanoma and MAPK Pathways
- Hematopoietic Stem Cell Transplantation
- Zoonotic diseases and public health
- Hidradenitis Suppurativa and Treatments
- Chemotherapy-related skin toxicity
- Muscle Physiology and Disorders
- Polyomavirus and related diseases
- Viral-associated cancers and disorders
- Human-Animal Interaction Studies
- Virus-based gene therapy research
- Barrier Structure and Function Studies
- Neurogenesis and neuroplasticity mechanisms
- Probiotics and Fermented Foods
- Parvovirus B19 Infection Studies
- Pain Management and Opioid Use
- Vitamin D Research Studies
- Cutaneous Melanoma Detection and Management
- HER2/EGFR in Cancer Research
AbbVie (United States)
2017-2024
X-Fab (Germany)
2018
New England Biolabs (United States)
2004-2017
Harvard University
2004-2014
Primate Conservation
2014
Massachusetts General Hospital
2006-2007
Spaulding Rehabilitation Hospital
2005
Brigham and Women's Hospital
2004
While immune checkpoint blockade leads to potent antitumor efficacy, it also immune-related adverse events in cancer patients. These toxicities stem from systemic activation resulting inflammation of multiple organs, including the gastrointestinal tract, lung, and endocrine organs. We developed a dual variable domain immunoglobulin anti-CTLA4 antibody (anti-CTLA4 DVD, where CTLA4 is defined as cytotoxic T lymphocyte–associated antigen-4) possessing an outer tumor-specific antigen-binding...
Vascular permeability and inflammatory demyelination are intimately linked in the brain, but what is their temporal relationship? We aimed to determine radiological correlates of earliest tissue changes accompanying a primate model multiple sclerosis (MS), experimental autoimmune encephalomyelitis (EAE) common marmoset.By 7T magnetic resonance imaging (MRI), T1 maps, proton density, T2-weighted images were acquired before after EAE induction 5 marmosets (every other week lesions appeared,...
Human Herpesvirus 6 (HHV-6) is a ubiquitous virus with an estimated seroprevalence of 95% in the adult population. HHV-6 associated several neurologic disorders, including multiple sclerosis, inflammatory demyelinating disease affecting CNS. Animal models infection would help clarify its role human but have been slow to develop because rodents lack CD46, receptor for cellular entry. Therefore, we investigated effects infections non-human primate, common marmoset Callithrix jacchus. We...
The tumor necrosis factor (TNF) and IL-23/IL-17 axes are the main therapeutic targets in spondyloarthritis. Despite clinical efficacy of blocking either pathway, monotherapy does not induce remission all patients its effect on new bone formation remains unclear. We aimed to study TNF IL-17A dual inhibition disease structural damage using HLA-B27/human β2-microglobulin transgenic rat model SpA. Immunized rats were randomized according arthritis severity, 1 week after incidence reached 50%, be...
The pathogenesis of human immunodeficiency virus transmission via the rectal route remains poorly understood. By use simian (SIV)–rhesus macaque model and intrarectal inoculation with pathogenic SIVmac251, a significant increase was found in percentage CD11b+ monocyte lineage cells expressing HLA-DR and/or B7-2 local peripheral immune inductive sites, but not mucosal effector as early 7 days after up to 50 inoculation. Moreover, at 21 inoculation, only gut also lung mucosa were depleted CD4+...
A change in coreceptor preference from CCR5 to CXCR4 towards the end stage disease some HIV-1 infected individuals has been well documented, but reasons and mechanisms for this tropism switch remain elusive. It suggested that envelope structural constraints accommodating amino acid changes required usage is an obstacle switch, limiting rate pathways available switching. The present study was initiated two R5 SHIVSF162P3N-infected rapid progressor macaques with test hypothesis early step...
Mutations in the Interleukin (IL)-23/IL-23 receptor loci are associated with increased inflammatory bowel disease (IBD) susceptibility, and IL-23 neutralization has shown efficacy early clinical trials. To better understand how an excess of affects gastrointestinal tract, we investigated chronic systemic exposure healthy wildtype mice. As expected, resulted activation intestinal type 3 innate lymphoid cells (ILC3), followed by infiltration activated RORγt+ T helper cells. Surprisingly,...
DC inhibitory receptor (DCIR) is a C-type lectin selectively expressed on myeloid cells, including monocytes, macrophages, DCs, and neutrophils. Its role in immune regulation has been implicated murine models human genome-wide association studies, suggesting defective DCIR function associates with increased susceptibility to autoimmune diseases such as rheumatoid arthritis, lupus, Sjögren's syndrome. However, little known about the mechanisms underlying activation dampen inflammation. Here,...
We have shown that glial cell line‐derived neurotrophic factor (GDNF) given by the nasal route of administration provides significant protection substantia nigra (SN) dopamine neurons in rat 6‐hydroxydopmaine model Parkinson's Disease (PD). The next step preclinical development is to test efficacy intranasal GDNF a primate PD. Eighteen common marmosets (Callithrix jacchus) were three doses MPTP (2 mg/kg on day 1 and days 2 3) induce partial lesion SN neurons. Nine animals received 5 daily...
Adalimumab, but neither etanercept nor certolizumab-pegol, has been reported to induce a wound healing profile in vitro by regulating macrophage differentiation and matrix metalloproteinase expression, which may underlie the differences efficacy between various tumor necrosis factor alpha (TNF) inhibitors impaired patients with hidradenitis suppurativa (HS), chronic inflammatory skin disease. To examine compare of TNF cutaneous vivo, human knock-in Leprdb/db mouse model was established as...
<h3>Background</h3> The CXCL12/CXCR4 chemokine axis has been implicated in the pathogenesis of RA. expression this and receptor shown to be increased RA synovium, moreover, CXCR4 levels synovium have correlated with joint destruction patients. <h3>Objectives</h3> Given that high are associated pathogenesis, we sought determine whether altered by adalimumab (ADA) both <i>in vivo</i> patients human TNF transgenic mouse model (huTNF Tg197) arthritis, as well vitro</i> fibroblast-like...
Graft versus host disease (GvHD) is an often fatal complication of allogeneic tissue transplantation. While typical targets GvHD include the skin, lung, liver and GI tract, a myriad other organ systems are being identified as this disease. Although neurologic complications that occur during hematopoietic stem cell transplant (HCT) have been extensively described (Siegal et al., BBMT, 2007), little information available about incidence biology in central nervous system (CNS). Case reports...