A5033731329- Immune Cell Function and Interaction
- Synthesis and biological activity
- SARS-CoV-2 and COVID-19 Research
- T-cell and B-cell Immunology
- Plant and animal studies
- Streptococcal Infections and Treatments
- HIV Research and Treatment
- CAR-T cell therapy research
- Network Security and Intrusion Detection
- SARS-CoV-2 detection and testing
- Plant Micronutrient Interactions and Effects
- Plant Parasitism and Resistance
- Cytomegalovirus and herpesvirus research
- Click Chemistry and Applications
- Antimicrobial Resistance in Staphylococcus
- Wheat and Barley Genetics and Pathology
- Photodynamic Therapy Research Studies
- Neonatal and Maternal Infections
- Monoclonal and Polyclonal Antibodies Research
- Plant Molecular Biology Research
- Advanced Biosensing Techniques and Applications
- Herpesvirus Infections and Treatments
- Polyomavirus and related diseases
- Infective Endocarditis Diagnosis and Management
- Opportunistic and Delay-Tolerant Networks
University of Auckland
2018-2024
Birla Institute of Technology and Science, Pilani
2019-2024
Eternal University
2018-2023
Dr. Babasaheb Ambedkar Marathwada University
2022-2023
Regeneron (United States)
2023
University of Basel
2023
Fraunhofer Institute for Digital Media Technology
2021
Plant & Food Research
2018-2020
Eli Lilly (United States)
2020
Emory National Primate Research Center
2012-2018
Chronic liver disease mediated by activation of hepatic stellate cells (HSCs) leads to fibrosis. Here, we postulated that the immune regulatory properties HSCs might promote profibrogenic activity B cells. Fibrosis is completely attenuated in carbon tetrachloride–treated, cell–deficient µMT mice, showing are required. The retinoic acid produced augmented B‐cell survival, plasma cell marker CD138 expression, and immunoglobulin G production. These activities were reversed following addition...
Controlling graft-versus-host disease (GVHD) remains a major unmet need in stem cell transplantation, and new, targeted therapies are being actively developed. CD28-CD80/86 costimulation blockade represents promising strategy, but targeting CD80/CD86 with CTLA4-Ig may be associated undesired of coinhibitory pathways. In contrast, CD28 exclusively inhibits T more potently prevent GVHD. Here, we investigated FR104, an antagonistic CD28-specific pegylated-Fab′, the nonhuman primate (NHP) GVHD...
Abstract This paper reviews institutional reforms in the irrigation sector for sustainable agricultural water management (AWM) undertaken 14 countries and regions, including Australia, China, India, Indonesia, Iran, Japan, Malaysia, Mexico, Nepal, South Korea, Sudan, Chinese Taipei, Turkey Ukraine. These regions represent a vast diversity of geography, climate, governance, socio‐economic conditions level development. In those with smaller land areas high‐technology manufacturing, such as...
CD3-engaging bispecific antibodies (bsAbs) and chimeric antigen receptor (CAR) T cells are potent therapeutic approaches for redirecting patient to recognize kill tumors. Here we describe a fully human bsAb (REGN5458) that binds B-cell maturation (BCMA) CD3, compare its antitumor activities vs those of anti-BCMA CAR identify differences in efficacy mechanism action. In vitro, BCMAxCD3 efficiently induced polyclonal T-cell killing primary plasma multiple myeloma (MM) cell lines expressing...
Understanding the immune profile of acute rheumatic fever (ARF), a serious post-infectious sequelae
M1UK is associated with current surges in invasive infection globally, partly due to increased production of superantigen streptococcal pyrogenic exotoxin A. We show that now the dominant emm1 lineage Aotearoa New Zealand and genomically related community infections, suggesting measures effectively prevent group A Streptococcus pharyngitis children could reduce disease.
Introduction During HIV infection the severe depletion of intestinal CD4+ T-cells is associated with microbial translocation, systemic immune activation, and disease progression. This study examined peripheral T-cell subsets reconstitution under combined antiretroviral therapy (cART), activation markers. Methods longitudinal single-arm pilot evaluates T cells, including Th1 Th17, in gut blood soluble markers for inflammation HIV-infected individuals before (M0) after eight (M8) months cART....
The CD137 receptor plays a key role in mediating immune response by promoting T cell proliferation, survival, and memory. Effective agonism of has the potential to reinvigorate potent antitumor immunity either alone or combination with other immune-checkpoint therapies. In this study, we describe discovery characterization unique agonist, 7A5, fully human IgG1 Fc effector-null monoclonal antibody. biological properties 7A5 were investigated through vitro vivo studies. binds CD137, binding...
Vaccine hesitancy plays a crucial role in slowing down the efforts towards achieving an immunized and healthy society, particularly, children women. VH is very conspicuous among economically marginalized tribal indigenous population. Previous research papers have not presented comparative scenario between for RI COVID-19 discussed detail different reasons behind from gender perspective The key question this systematic review whether vaccine routine child vaccination population will reduce or...
Although XMRV dissemination in humans is a matter of debate, the prostate select patients seem to harbor XMRV, which raises questions about its potential route transmission. We established model infection rhesus macaques inoculated with XMRV. In spite intravenous inoculation, all infected exhibited readily detectable signal reproductive tract 4 males and 1 female during both acute chronic stages. showed explosive growth acini but not infection. seminal vesicles, epididymis, testes, protein...
Serological assays that detect antibodies to SARS-CoV-2 are critical for determining past infection and investigating immune responses in the COVID-19 pandemic. We established ELISA-based immunoassays using locally produced antigens when New Zealand went into a nationwide lockdown supply chain of diagnostic reagents was widely held domestic concern. The relationship between serum antibody binding measured by ELISA neutralising capacity investigated surrogate viral neutralisation test...
Abstract Surges in infections caused by respiratory pathogens have been documented multiple settings after relaxation of pandemic restrictions. Antibodies to major antigens from syncytial virus and Group A Streptococcus waned significantly a longitudinal adult cohort throughout the pandemic. This waning may contributed pathogen-surges that followed.
In many urban areas, traffic load and noise pollution are constantly increasing. Automated systems for monitoring promising countermeasures, which allow to systematically quantify predict local flow in order support municipal planning decisions. this paper, we present a novel open benchmark dataset, containing 15,706 2-second long stereo audio clips, were extracted from 4718 vehicle passing events captured with both high-quality sE8 medium-quality MEMS microphones. This dataset is well...
Abstract Background The sooty mangabey is a vulnerable West African species that naturally harbors simian immunodeficiency virus ( SIV ) without pathological symptoms. We present normative hematology and serum chemistry values for this species. Methods Hematology analytes from 136 females 96 males 57 26 were studied. Results Values of several fell outside published reference ranges in the rhesus monkey, laboratory standard Old World primates. Erythrocyte‐related parameters higher mangabeys...
Group A Streptococcus (GAS) is a leading human pathogen for which there no licensed vaccine. Infections are most common in young children and the elderly suggesting immunity accumulates with exposure until immune senescence older age. Though protection has been postulated to be strain type specific, based on M-protein (emm-type), antigenic basis of population-level remains poorly understood. Naturally acquired GAS antibody responses were investigated using intravenous immunoglobulin (IVIG),...
Abstract Strigolactones (SLs) are multifunctional plant hormones regulating essential physiological processes affecting growth and development. In vascular plants, SLs recognized by α/β hydrolase-fold proteins from the D14/DAD2 (Dwarf14/Decreased Apical Dominance 2) family in initial step of signaling pathway. We have previously discovered that N-phenylanthranilic acid derivatives (e.g. tolfenamic acid) potent antagonists SL receptors, prompting us to design quinazolinone quinazolinedione...