A5101814170- Inflammasome and immune disorders
- Gout, Hyperuricemia, Uric Acid
- Streptococcal Infections and Treatments
- Immune Response and Inflammation
- Insurance, Mortality, Demography, Risk Management
- Health disparities and outcomes
- Grief, Bereavement, and Mental Health
- Global Health Care Issues
- Zoonotic diseases and public health
- Demographic Trends and Gender Preferences
- Economics of Agriculture and Food Markets
- T-cell and B-cell Immunology
- Mine drainage and remediation techniques
- Radioactive element chemistry and processing
- Antimicrobial Resistance in Staphylococcus
- Glioma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Intellectual Capital and Performance Analysis
- Pneumocystis jirovecii pneumonia detection and treatment
- Income, Poverty, and Inequality
- ATP Synthase and ATPases Research
- Dermatological and COVID-19 studies
- Rangeland Management and Livestock Ecology
- Carbohydrate Chemistry and Synthesis
- Hormonal Regulation and Hypertension
Augusta University
2018-2023
Callaghan Innovation
2019-2021
Ministry of Business, Innovation and Employment
2021
Institute for Progressive Medicine
2014-2020
Walter and Eliza Hall Institute of Medical Research
1967-2018
The University of Melbourne
2015-2018
Theravance Biopharma (United States)
2011-2014
University of California, Los Angeles
2012
Malaghan Institute of Medical Research
2008-2012
Institute of Geographic Sciences and Natural Resources Research
2007
In the United States, approximately 35% of adults with Systemic Lupus Erythematosus (SLE) have clinical evidence nephritis at time diagnosis; an estimated total 50–60% developing during first 10 years disease [1–4]. The prevalence is significantly higher in African Americans and Hispanics than Caucasians, men women. Renal damage more likely to develop non-Caucasian groups [2–4]. Overall survival patients SLE 95% 5 after diagnosis 92% [5, 6]. presence lupus reduces survival, 88% years, even...
Abstract Objective To determine whether infiltrating monocytes, neutrophils, or resident macrophages contribute to the early inflammatory response monosodium urate monohydrate (MSU) crystals in vivo. Methods MSU crystal–induced inflammation was monitored using a peritoneal model of acute gout. The production proinflammatory cytokines (interleukin‐1β [IL‐1β], tumor necrosis factor α [TNFα], IL‐6) by macrophages, and neutrophils during onset gout determined flow cytometry. Infiltrating cells...
In the anterior maxilla, dental implant–supported prostheses need to replicate hard and soft tissues in order be esthetically acceptable. Three systematic reviews Group 3 were prepared address topic of optimizing esthetic outcomes. Following tooth extraction, clinician has choice various time points place implants. Implant placement postextraction is often accompanied by bone augmentation procedures manage residual defects enhance results. Thus, first review Chen Buser analyzed influence...
To profile monosodium urate monohydrate (MSU) crystal-recruited monocyte inflammatory function during the course of in vivo differentiation, a murine model peritoneal MSU crystal-induced inflammation.C57BL/6J mice were injected intraperitoneally with crystals, and cells harvested at different time points. The monocyte/macrophage population was analyzed for expression differentiation activation markers, cytokine production following crystal restimulation ex vivo, NLRP3-associated proteins...
Abstract Background Recurrent brain tumors are the leading cause of cancer death in children. Indoleamine 2,3-dioxygenase (IDO) is a targetable metabolic checkpoint that, preclinical models, inhibits anti-tumor immunity following chemotherapy. Methods We conducted phase I trial (NCT02502708) oral IDO-pathway inhibitor indoximod children with recurrent or newly diagnosed diffuse intrinsic pontine glioma (DIPG). Separate dose-finding arms were performed for combination temozolomide (200...
Experiments were designed to test the possibility that thymus-derived (T) cells cooperate with nonthymus derived (B) in antibody responses by acting as passive carriers of antigen. Thoracic duct lymphocytes (TDL) from fowl gammaG-tolerant mice incubated vitro anti-mouse lymphocyte globulin (FALG), which was shown not be immunosuppressive mice. On transfer into adult thymectomized, irradiated, and marrow protected (TxBM) hosts together a control antigen, horse RBC, response RBC but gammaG...
Can cultural identity be a disadvantage for indigenous employees? it lead to critical issues around workload and pressures? This article explores the role of Māori, people Aotearoa/New Zealand, findings are telling. We target Māori scientists, given their limited number but growing legislated sector demands engagement. conducted several studies. Study one (12 interviews) identified themes whakawhanaungatanga (relationship management), kawenga (responsibilities) taumaha (workload). two (wave...
Background: Acute rheumatic fever (ARF) and heart disease are autoimmune consequences of group A streptococcus infection remain major causes cardiovascular morbidity mortality around the world. Improved treatment has been stymied by gaps in understanding key steps immunopathogenesis ARF disease. This study aimed to identify (1) effector T cell cytokine(s) that might be dysregulated response patients with streptococcus, (2) an immunomodulatory agent suppresses this could clinically...
The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. work eugenicists was often pervaded prejudice against racial, ethnic and disabled groups. publication this material research purposes is not endorsement those views nor a promotion eugenics in any way.
Understanding the immune profile of acute rheumatic fever (ARF), a serious post-infectious sequelae
This paper focuses on current efforts to demonstrate the value of knowledge in organisations with reference activities and systems for measurement intangibles. These stem largely from widespread dissatisfaction manner which traditional accounting methods treat The wider context is that national international governments striving master drivers knowledge‐based change by involvement research projects, conferences, attempts find new means representing intangibles standard industrial...
Research Articles| July 21 2009 Assay for the Immunosuppressive Capacity of Antilymphocyte Serum Based on its Action Thymus-Derived Cells Subject Area: Immunology and Allergy W.J. Martin; Martin The Walter Eliza Hall Institute Medical Research, Royal Melbourne Hospital, Melbourne, Australia Search other works by this author on: This Site PubMed Google Scholar J.F.A.P. Miller International Archives Applied (1969) 35 (2): 163–178. https://doi.org/10.1159/000230169 Article history Published...