A5047319652- interferon and immune responses
- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- Virus-based gene therapy research
- Cancer-related molecular mechanisms research
- Sepsis Diagnosis and Treatment
- Microtubule and mitosis dynamics
- Acute Kidney Injury Research
- Nutrition and Health in Aging
- Wnt/β-catenin signaling in development and cancer
- Wind and Air Flow Studies
- Structural Analysis of Composite Materials
- Pancreatitis Pathology and Treatment
- Phagocytosis and Immune Regulation
- Gallbladder and Bile Duct Disorders
- Genomics, phytochemicals, and oxidative stress
- Diet and metabolism studies
- Lipid metabolism and disorders
- Paraquat toxicity studies and treatments
- Traditional Chinese Medicine Analysis
- Probabilistic and Robust Engineering Design
- Herpesvirus Infections and Treatments
- Immune Response and Inflammation
- Cytomegalovirus and herpesvirus research
- RNA Interference and Gene Delivery
Shandong Normal University
2022-2025
Zhengzhou University
2022
First Affiliated Hospital of Zhengzhou University
2022
Nanjing Medical University
2021
Wenzhou Medical University
2021
Dongyang People's Hospital
2021
Huaian First People’s Hospital
2021
Second Affiliated Hospital of Nanchang University
2018
Nanchang University
2018
Texas Tech University
2005
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is closely related to various cellular aspects associated with autophagy. However, how SARS-CoV-2 mediates the subversion of macroautophagy/autophagy pathway remains largely unclear. In this study, we demonstrate that overexpression ORF7a protein activates LC3-II and leads accumulation autophagosomes in multiple cell lines, while knockdown viral gene via shRNAs targeting sgRNA during decreased autophagy levels....
Phenazine biosynthesis-like domain-containing protein (PBLD) and Cedrelone have been identified as tumor suppressors. However, their roles in virus infection remain unclear. Here, we demonstrate that PBLD upregulates the type I interferon (IFN-I) response through activating NF-kappaB (NF-κB) signaling pathway to resist viral cells mice. Mechanistically, activates NF-κB during via blocking tripartite motif containing 21 (TRIM21)-mediated phosphorylated inhibitory kappa B kinase beta (IKKβ)...
The sperm-associated antigen 5 (SPAG5) plays a key role in controlling various cellular phenomena, including cell cycle progression and proliferation. However, the of SPAG5 hepatocellular carcinoma (HCC) remains unknown.This study investigated function clinical significance protein expression carcinoma. We analyzed surgical specimens from 136 HCC patients. correlation between characteristics prognosis was also determined. Furthermore, overexpressed silenced with shRNA cells. Moreover,...
Progressive proteinuria is one of the earliest clinical features diabetic nephropathy (DN). In our previous study, lncRNA DLX6-AS1 (DLX6-AS1, Dlx6os1 in mouse) was found to be associated with extent albuminuria DN patients. Furthermore, lack pivotal switching off inflammatory response db/db mouse model. However, regulatory factors responsible for elevated remains unknown.To identify potential DLX6-AS1, JASPAR database and DNA pull down combined subsequent liquid chromatography-tandem mass...
Purpose: Considerable evidence suggests that inflammation and malnutrition are common in patients with acute kidney injury (AKI) correlated mortality of various diseases. Despite this, few studies have reported the underlying predictive effects inflammatory nutritional markers combination on AKI patients. Herein, we aimed to explore values PCT CRP as well ratios PCT/Alb CRP/Alb poor prognosis sepsis-induced AKI. Patients Methods: A total 171 AKI, caused by abdominal infection-evoked sepsis,...
Phenazine biosynthesis-like domain-containing protein (PBLD) has been reported to be involved in the development of many cancers. However, whether PBLD regulates innate immune responses and viral replication is unclear. In this study, although it was found that activity extends other PRRs, we focused on RLR pathway activated via p53–USP4–MAVS axis response virus infections. We deubiquitinates stabilizes MAVS through ubiquitin-specific protease 4 (USP4) promote antiviral immunity....
Sepsis, with its high morbidity and mortality, is a difficult problem in critical care medicine. The purpose of this study to investigate the involvement GRB2-associated binding protein 1 (GAB1) septic lung injury. Lipopolysaccharide (LPS)-induced mouse model A549 cell were used simulate Haematoxylin eosin (H&E) staining was observe pathological changes. terminal-deoxynucleotidyl transferase/(TdT)-mediated dUTP-biotin nick end labelling (TUNEL) flow cytometry detect apoptosis. levels...
Objective To summarize clinical experience of laparoscopic hepatectomy in the treatment hepatolithiasis. Methods Clinical data 78 patients with hepatolithiasis undergoing Second Affiliated Hospital Nanchang University from March 2016 to 2017 were retrospectively analyzed. The informed consents all obtained and local ethical committee approval was received. Among them, 29 cases male 49 female, aged 20-80 years a median age 54 years. All underwent hepatectomy. Choledocholithotomy...
Objective To explore the protective effects of cannabinoid analogues WIN55212-2 on paraquat poisoned mice. Methods Totally 35 healthy male C57BL/6 mice were randomly(random number) divided into four groups: PQ group (paraquat poisoned, n=10), WIN 1 mg (PQ+WIN55212-2 2 mg, control (n=5). The animal models established in group, and by intraperitoneally injection with a concentration 20 mg/kg. Intraperitoneal (containing Tween 80 cosolvent) at mg/kg was performed h before exposure two...