A5103012555- Epigenetics and DNA Methylation
- Advanced Chemical Physics Studies
- Cancer-related molecular mechanisms research
- Metal complexes synthesis and properties
- Cancer-related gene regulation
- Inflammatory Biomarkers in Disease Prognosis
- Molecular Spectroscopy and Structure
- Mitochondrial Function and Pathology
- Mass Spectrometry Techniques and Applications
- Endoplasmic Reticulum Stress and Disease
- RNA modifications and cancer
- Congenital heart defects research
- Heat shock proteins research
- Spectroscopy and Quantum Chemical Studies
- DNA and Nucleic Acid Chemistry
- Cancer therapeutics and mechanisms
- Pluripotent Stem Cells Research
- Bioactive Compounds and Antitumor Agents
- Biochemical effects in animals
- Helicobacter pylori-related gastroenterology studies
- Adenosine and Purinergic Signaling
- Ophthalmology and Visual Health Research
- Traditional and Medicinal Uses of Annonaceae
- Organic Chemistry Synthesis Methods
- Photochemistry and Electron Transfer Studies
Xuzhou Medical College
2025
Shandong Normal University
2025
Northwest A&F University
2025
Georgia State University
2019-2024
South China Normal University
2019-2022
Key Laboratory of Guangdong Province
2021
Sir Run Run Shaw Hospital
2020
Zhejiang University
2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2019
Shandong University
2018
Objectives The aim of this study was to elucidate the impact nutritional status on survival per Controlling Nutritional Status (CONUT) score and Geriatric Risk Index (GNRI) in patients with hypertension over 80 years age. Design Prospective follow-up study. Participants A total 336 hypertensive old were included Outcome measures All-cause deaths recorded as Kaplan-Meier curves evaluate association between CONUT all-cause mortality at follow-up. Cox regression models used investigate...
Phenazine biosynthesis-like domain-containing protein (PBLD) and Cedrelone have been identified as tumor suppressors. However, their roles in virus infection remain unclear. Here, we demonstrate that PBLD upregulates the type I interferon (IFN-I) response through activating NF-kappaB (NF-κB) signaling pathway to resist viral cells mice. Mechanistically, activates NF-κB during via blocking tripartite motif containing 21 (TRIM21)-mediated phosphorylated inhibitory kappa B kinase beta (IKKβ)...
Immuno-inflammation plays a major role in the process of hypertension. We aimed to evaluate association between inflammatory markers, neutrophil-to-lymphocyte ratio (NLR), red cell distribution width (RDW) and all-cause mortality elderly patients with A total 341 hypertensive over 80 years age were included this study. The NLR RDW measured on admission all selected followed up for 90 days. Kaplan–Meier curves plotted at follow-up. Using Cox regression models, we investigated prognostic value...
Objective To evaluate the predictive value of dual-energy CT angiography (DECTA) parameters carotid intraplaque and perivascular adipose tissue (PVAT) in acute stroke events. Methods A retrospective analysis was conducted using clinical, laboratory, imaging data from patients who underwent CTA cranial MRI. Acute cerebral infarctions occurring ipsilateral anterior circulation were classified as symptomatic group (STA group), while other cases categorized asymptomatic (ATA group). LASSO...
SMYD proteins are an exciting field of study as they linked to many types cancer-related pathways. Cardiac and skeletal muscle development function also depend on opening a possible avenue for cardiac-related treatment. Previous crystal structure studies have revealed that this special class protein lysine methyltransferases bilobal structure, open–closed motion may regulate substrate specificity. Here we use the molecular dynamics simulation investigate still-poorly-understood SMYD2...
A new CN covalent bond was formed between acrylonitrile and ammonia in ionization state.
Protein interactions that stabilize the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) at apical membranes of epithelial cells have not yet been fully elucidated. We identified keratin 19 (CK19 or K19) as a novel CFTR-interacting protein. CK19 overexpression stabilized both wild-type (WT)-CFTR and Lumacaftor (VX-809)-rescued F508del-CFTR (where F508del is deletion phenylalanine residue position 508) plasma membrane (PM), promoting Cl
The first spectral evidence for the formation of stable hemibonds between second-period elements (nitrogen or oxygen) and third-period (sulfur) in gas phase.
Prebiotic molecules have often been identified in the interstellar medium and meteorite samples. However, we still only a fragmentary knowledge of mechanism evolutionary process these prebiotic molecules. With aid state-of-the-art vacuum ultraviolet (VUV)-infrared (IR) spectroscopy ab initio calculations, reveal new pathway leading to formation biorelevant carrying amine groups or peptide bonds via single-photon ionization induced Michael/cyclization reaction acrylonitrile (AN)–alcohol...
SMYD3 plays a key role in cancer cell viability, adhesion, migration and invasion. promotes formation of inducible regulatory T cells is involved reducing autoimmunity. However, the nearly "closed" substrate-binding site poor vitro H3K4 methyltransferase activity have obscured further understanding this oncogenically related protein. Here we reveal that can adopt an "open" conformation using molecular dynamics simulation small-angle X-ray scattering. This ligand-binding-capable open state to...
Valosin-containing protein (VCP) was found to play a vital protective role against cardiac stresses. Genetic mutations of VCP are associated with human dilated cardiomyopathy. However, the essential in heart during physiological condition remains unknown since knockout mice is embryonically lethal. We generated cardiac-specific dominant-negative transgenic (DN-VCP TG) mouse determine effects impaired activity on heart. Using echocardiography, we showed that overexpression DN-VCP induced...
The present study aimed to investigate the signaling pathways and underlying molecular mechanisms involved in ethanol‑induced intestinal epithelial barrier (IEB) dysfunction. Therefore, an vitro experimental model of IEB was established using ethanol‑treated Caco‑2 cell monolayer. results confirmed that Rho‑associated kinases (ROCKs), namely ROCK1 ROCK2, were pathway Ethanol exposure significantly increased expression both ROCK isoforms activity nuclear factor κB (NF‑κB). Furthermore, ROCK1‑...