A5033002324- Acute Lymphoblastic Leukemia research
- Epigenetics and DNA Methylation
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Childhood Cancer Survivors' Quality of Life
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- Pluripotent Stem Cells Research
- T-cell and B-cell Immunology
- RNA Interference and Gene Delivery
- CAR-T cell therapy research
- Chronic Lymphocytic Leukemia Research
- Virology and Viral Diseases
- Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- Multiple Myeloma Research and Treatments
- Cancer Genomics and Diagnostics
- Electromagnetic Fields and Biological Effects
- Mosquito-borne diseases and control
- RNA and protein synthesis mechanisms
- Cancer-related gene regulation
- Immunotherapy and Immune Responses
- Microtubule and mitosis dynamics
- FOXO transcription factor regulation
- T-cell and Retrovirus Studies
Centro de Biología Molecular Severo Ochoa
2015-2024
Universidad Autónoma de Madrid
2015-2024
Consejo Superior de Investigaciones Científicas
1998-2023
Centro de Investigación del Cáncer
2001-2012
Universidad de Salamanca
1997-2012
National Research Council
2012
Research Institute of Molecular Pathology
2002-2009
Vienna Biocenter
2007-2009
Abstract The historical lack of preclinical models reflecting the genetic heterogeneity multiple myeloma (MM) hampers advance therapeutic discoveries. To circumvent this limitation, we screened mice engineered to carry eight MM lesions (NF-κB, KRAS, MYC, TP53, BCL2, cyclin D1, MMSET/NSD2 and c-MAF) combinatorially activated in B lymphocytes following T cell-driven immunization. Fifteen genetically diverse developed bone marrow (BM) tumors fulfilling pathogenesis. Integrative analyses ∼500...
Abstract Earlier in the past century, infections were regarded as most likely cause of childhood B-cell precursor acute lymphoblastic leukemia (pB-ALL). However, there is a lack relevant biologic evidence supporting this hypothesis. We present vivo genetic mechanistically connecting inherited susceptibility to pB-ALL and postnatal by showing that was initiated Pax5 heterozygous mice only when they exposed common pathogens. Strikingly, these murine pB-ALLs closely resemble human disease....
Abstract ETV6-RUNX1 is associated with the most common subtype of childhood leukemia. As few carriers develop precursor B-cell acute lymphocytic leukemia (pB-ALL), underlying genetic basis for development full-blown remains to be identified, but appearance cases in time-space clusters keeps infection as a potential causal factor. Here, we present vivo evidence mechanistically connecting preleukemic expression hematopoetic stem cells/precursor cells (HSC/PC) and postnatal infections...
Chromosomal translocations involving the MALT1 gene are hallmarks of mucosa-associated lymphoid tissue (MALT) lymphoma. To date, targeting these to mouse B cells has failed reproduce human disease. Here, we induced expression in Sca1 + Lin − hematopoietic stem/progenitor cells, which showed NF-κB activation and early priming, being selectively skewed toward B-cell differentiation. These accumulated extranodal tissues gave rise clonal tumors recapitulating principal clinical, biological,...
Summary: The recognition of host genetic factors underlying susceptibility to hematopoietic malignancies has increased greatly over the last decade. Historically, germline predisposition was thought primarily affect young. However, emerging data indicate that develop in people all ages across human lifespan can derive from predisposing conditions and are not exclusively observed younger individuals. age at which manifest appears correlate with distinct biological pathways. Progression having...
Abstract NKX2 homeobox family proteins have a role in cancer development. Here we show that - 3 is overexpressed tumour cells from subset of patients with marginal-zone lymphomas, but not other B-cell malignancies. While Nkx2-3 -deficient mice exhibit the absence B cells, transgenic expression NKX2-3 expansion leads to development tumours, faithfully recapitulating principal clinical and biological features human lymphomas. induces receptor signalling by phosphorylating Lyn/Syk kinases,...
Developmental processes require a precise regulation of all the aspects cellular function to successfully achieve generation differentiated cells. This does not only encompass gene expression levels activating developmental programs, but should also attend demanding energetic needs differentiating Epigenetic regulators are essential for establishing cell-type-specific transcriptional emerging evidence suggests that they play more direct role in regulating metabolism. Nsd2 is...