A5086294439- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Chronic Lymphocytic Leukemia Research
- Childhood Cancer Survivors' Quality of Life
- RNA Interference and Gene Delivery
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- T-cell and Retrovirus Studies
- Cancer Cells and Metastasis
- Pluripotent Stem Cells Research
- DNA Repair Mechanisms
- Neuroblastoma Research and Treatments
- Carcinogens and Genotoxicity Assessment
- RNA modifications and cancer
- DNA and Nucleic Acid Chemistry
- Nanoplatforms for cancer theranostics
- Immune Cell Function and Interaction
- Histone Deacetylase Inhibitors Research
- Bariatric Surgery and Outcomes
- Immunotherapy and Immune Responses
- Retinoids in leukemia and cellular processes
- Cancer therapeutics and mechanisms
- Vector-Borne Animal Diseases
Instituto de Investigación Biomédica de Salamanca
2013-2018
Centro de Investigación del Cáncer
2014-2018
Universidad de Salamanca
2013-2018
Consejo Superior de Investigaciones Científicas
2017
Biblioteca Nacional de España
2014
Translational Research in Oncology
2013
Instituto de Biologia Molecular e Celular
2013
Abstract Earlier in the past century, infections were regarded as most likely cause of childhood B-cell precursor acute lymphoblastic leukemia (pB-ALL). However, there is a lack relevant biologic evidence supporting this hypothesis. We present vivo genetic mechanistically connecting inherited susceptibility to pB-ALL and postnatal by showing that was initiated Pax5 heterozygous mice only when they exposed common pathogens. Strikingly, these murine pB-ALLs closely resemble human disease....
Abstract ETV6-RUNX1 is associated with the most common subtype of childhood leukemia. As few carriers develop precursor B-cell acute lymphocytic leukemia (pB-ALL), underlying genetic basis for development full-blown remains to be identified, but appearance cases in time-space clusters keeps infection as a potential causal factor. Here, we present vivo evidence mechanistically connecting preleukemic expression hematopoetic stem cells/precursor cells (HSC/PC) and postnatal infections...
Preleukemic clones carrying
Obesity and its complications are associated with high morbidity/mortality a significant healthcare cost burden in Spain. It is therefore essential to know the potential clinical economic benefits of reducing obesity. The objective this study predict decrease rates onset obesity savings after weight loss 15% over 10 years Data were combined an adapted version benefit simulation model. Sources demographic information on Spanish population distribution type 2 diabetes mellitus (T2DM) used...
Article7 June 2018Open Access Transparent process Lmo2 expression defines tumor cell identity during T-cell leukemogenesis Idoia García-Ramírez Experimental Therapeutics and Translational Oncology Program, Instituto de Biología Molecular y Celular del Cáncer, CSIC-USAL, Salamanca, Spain Institute of Biomedical Research Salamanca (IBSAL), Search for more papers by this author Sanil Bhatia Department Pediatric Oncology, Hematology Clinical Immunology, Medical Faculty, Heinrich-Heine University...
Leukaemia cells that are resistant to conventional therapies thought reside in protective niches. Here, we describe light-inducible polymeric retinoic acid (RA)-containing nanoparticles (NPs) with the capacity accumulate cytoplasm of leukaemia for several days and release their RA payloads within a few minutes upon exposure blue/UV light. Compared NPs not activated by light exposure, these more efficiently reduce clonogenicity bone marrow cancer from patients acute myeloid (AML) induce...
// Franziska Auer 1 , Deborah Ingenhag Stefan Pinkert Sven Kracker 2,3 Salima Hacein-Bey-Abina 4,5 Marina Cavazzana Michael Gombert Alberto Martin-Lorenzo 6,7 Min-Hui Lin Carolina Vicente-Dueñas 7 Isidro Sánchez-García Arndt Borkhardt and Julia Hauer Department of Pediatric Oncology, Hematology Clinical Immunology, Heinrich-Heine University Duesseldorf, Medical Faculty, Germany 2 Université Paris Descartes, Sorbonne Cité, Imagine Institute, Paris, France 3 INSERM UMR 1163, Human...
The latest studies of the interactions between oncogenes and its target cell have shown that certain may act as passengers to reprogram tissue-specific stem/progenitor into a malignant cancer stem state. In this study, we show genetic background influences tumoral reprogramming capacity using model Sca1-BCRABLp210 mice, where type tumor they develop, chronic myeloid leukemia (CML), is function reprogramming. mice containing FVB components were significantly more resistant CML. However, pure...
<div>Abstract<p><i>ETV6-RUNX1</i> is associated with the most common subtype of childhood leukemia. As few <i>ETV6-RUNX1</i> carriers develop precursor B-cell acute lymphocytic leukemia (pB-ALL), underlying genetic basis for development full-blown remains to be identified, but appearance cases in time-space clusters keeps infection as a potential causal factor. Here, we present <i>in vivo</i> evidence mechanistically connecting preleukemic...
<div>Abstract<p><i>ETV6-RUNX1</i> is associated with the most common subtype of childhood leukemia. As few <i>ETV6-RUNX1</i> carriers develop precursor B-cell acute lymphocytic leukemia (pB-ALL), underlying genetic basis for development full-blown remains to be identified, but appearance cases in time-space clusters keeps infection as a potential causal factor. Here, we present <i>in vivo</i> evidence mechanistically connecting preleukemic...
<div>Abstract<p>Preleukemic clones carrying <i>BCR-ABL</i><sup><i>p190</i></sup> oncogenic lesions are found in neonatal cord blood, where the majority of preleukemic carriers do not convert into precursor B-cell acute lymphoblastic leukemia (pB-ALL). However, critical question how these cells transform pB-ALL remains undefined. Here, we model a BCR-ABL<sup>p190</sup> state and show that limiting expression to hematopoietic...
<p>Differentially expressed genes in bone marrow tumors from Sca1-BCR-ABLp190 mice compared to wild-type B220+ B cells. (3692 genes-probesets with FDR = 0.05)</p>
<p>Supplementary Figures and Table legends as well supplementary methods</p>