A5024525126- Acute Lymphoblastic Leukemia research
- Lymphoma Diagnosis and Treatment
- Lichen and fungal ecology
- Chronic Myeloid Leukemia Treatments
- Mycorrhizal Fungi and Plant Interactions
- Botany and Plant Ecology Studies
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Epigenetics and DNA Methylation
- Viral-associated cancers and disorders
- Genetic factors in colorectal cancer
- Plant Pathogens and Fungal Diseases
- Cancer Genomics and Diagnostics
- RNA Interference and Gene Delivery
- T-cell and Retrovirus Studies
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Childhood Cancer Survivors' Quality of Life
- Genomic variations and chromosomal abnormalities
- Ethics and bioethics in healthcare
- CNS Lymphoma Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Carcinogens and Genotoxicity Assessment
Instituto de Investigación Biomédica de Salamanca
2014-2024
Complejo Hospitalario de Salamanca
2005-2024
Universidad de Salamanca
2014-2023
Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Frascati
2020
Centro de Investigación del Cáncer
2014-2018
Agencia Española de Consumo, Seguridad Alimentaría y Nutrición
2015-2016
Instituto Nacional de la Salud
2013
Ministry of Health
2013
Centro Nacional de Información Geográfica
2010
Universidad Complutense de Madrid
2002-2008
Abstract Parmelioid lichens are a diverse and ubiquitous group of foliose lichens. Generic delimitation in parmelioid has been state flux since the late 1960s with segregation large, heterogeneous genus Parmelia into numerous smaller genera. Recent molecular phylogenetic studies have demonstrated that some these new genera were monophyletic, not, others, previously believed to be unrelated, fell within single monophyletic groups, indicating need for revision generic delimitations. This study...
Abstract Earlier in the past century, infections were regarded as most likely cause of childhood B-cell precursor acute lymphoblastic leukemia (pB-ALL). However, there is a lack relevant biologic evidence supporting this hypothesis. We present vivo genetic mechanistically connecting inherited susceptibility to pB-ALL and postnatal by showing that was initiated Pax5 heterozygous mice only when they exposed common pathogens. Strikingly, these murine pB-ALLs closely resemble human disease....
Abstract Generic concepts in the parmelioid lichens have been discussed intensively over past three decades without reaching a broad consensus. We now employed molecular data from genes to provide basis for revised generic concept of containing Xanthoparmelia type lichenan. The phylogeny lichenan was reconstructed using combined Bayesian analysis nuclear ITS, LSU rDNA and mitochondrial SSU sequences, maximum parsimony also made comparison. 179 new partial sequences 58 taxa were generated 12...
Abstract The chemokine receptor CXCR4 has been implicated in the migration and trafficking of malignant B cells several haematological malignancies. Over‐expression identified tumours, but data concerning role this diffuse large cell lymphoma ( DLBCL ) are lacking. is a marker poor prognosis various neoplasms, correlating with metastatic disease decreased survival patients. We studied involvement vitro dissemination vivo. also evaluated prognostic significance 94 biopsies observed that level...
Abstract ETV6-RUNX1 is associated with the most common subtype of childhood leukemia. As few carriers develop precursor B-cell acute lymphocytic leukemia (pB-ALL), underlying genetic basis for development full-blown remains to be identified, but appearance cases in time-space clusters keeps infection as a potential causal factor. Here, we present vivo evidence mechanistically connecting preleukemic expression hematopoetic stem cells/precursor cells (HSC/PC) and postnatal infections...
Background and Aims G protein–coupled receptor (GPR) 55 is a putative cannabinoid receptor, l‐α‐lysophosphatidylinositol (LPI) its only known endogenous ligand. Although GPR55 has been linked to energy homeostasis in different organs, specific role lipid metabolism the liver contribution pathophysiology of nonalcoholic fatty disease (NAFLD) remains unknown. Approach Results We measured (1) expression patients with NAFLD compared individuals without obesity disease, as well animal models...
Summary Circulating tumour DNA (ctDNA) allows genotyping and minimal residual disease (MRD) detection in lymphomas. Using a next‐generation sequencing (NGS) approach (EuroClonality‐NDC), we evaluated the clinical prognostic value of ctDNA series R‐CHOP‐treated diffuse large B‐cell lymphoma (DLBCL) patients at baseline ( n = 68) after two cycles 59), monitored by metabolic imaging (positron emission tomography combined with computed [PET/CT]). A molecular marker was identified 61/68 (90%)...
Summary Crespo, A., Blanco, O. & Hawksworth, D. L.: The potential of mitochondrial DNA for establishing phylogeny and stabilising generic concepts in the parmelioid lichens. ‐ Taxon 50: 807–819. 2001. ISSN 0040‐0262. A satisfactory resolution current instability lichens, particularly Parmelia s.l., has not so far emerged from molecular studies. rDNA ITS sequence proven too variable SSU conserved to provide discrimination around family levels Parmeliaceae s.l. Studies 31 new sequences...
The phylogenetic relationships of 16 species Parmelia s. str. are presented based on sequences nuITS rDNA from 56 specimens, and β-tubulin gene 29 collections. serrana sp. nov. a Mediterranean morphologically very close to P. saxatilis is described. ernstiae the sister-group str., further undescribed North American complex may require recognition. isidiate squarrosa closely allied sorediate sulcata , which paraphyletic. Japanese samples cochleata form monophyletic group but too few...
Abstract Multicentric Castleman disease (MCD) is an uncommon lymphoproliferative disorder for which the best therapeutic option not yet well established. Immune‐related disorders are rare complications of MCD. We report on MCD case in a 23‐year‐old patient with extensive abdominal involvement and associated immune hemolytic anemia Raynaud phenomenon. He was negative human immunodeficiency virus (HIV) herpesvirus‐8 (HHV‐8). After 8 courses anti‐CD20 monoclonal antibody (rituximab), achieved...
Parmotrema is one of the larger genera segregated from Parmelia s. lat. Additional recently have been this large genus based mainly on morphological and chemical features. We employed molecular data three genes to continue a revision generic concept within parmelioid lichens. A Bayesian analysis nuclear ITS, LSU rDNA mitochondrial SSU sequences was performed. The Canomaculina, Concamerella, Parmelaria Rimelia appear nested Parmotrema. Alternative hypotheses maintain independence Concamerella...
Abstract: After a discussion of changing generic concepts in the parmelioid lichens, checklist with current species placements is presented. Twenty-five genera and 143 are accepted for Europe, which 17 112 belong to monophyletic clade. The individual countries from reported provided, along references key publications. Synonyms used at rank Europe cross-referenced, dates publication all names provided. One new combination made: Xanthoparmelia pulvinaris (syn. Parmelia , X. pseudohungarica ).
Abstract Seafood mislabeling is a problem worldwide because it may cause underreporting of species exploitation and have detrimental effects on endangered conservation. The persistence this has been documented for important commercial species, revealing the need to devote more effort provide effective management control measures. In study, we applied DNA authentication tools, sequences two mitochondrial genes, 245 samples fish marketed in Spain, one top consumer countries world. Fresh,...
Preleukemic clones carrying
Prognostic factors in Hodgkin lymphoma (HL) still fail to accurately identify high-risk patients. Tumor microenvironment HL is a current focus of research for risk definition but few studies have focused on infiltrating lymphocytes. Here, we analyzed the number tumor lymphocytes by flow cytometry diagnostic biopsies from 96 homogeneously treated patients with ABVD or without radiotherapy. Most lymph node cells were (90 ± 17), median T/B/NK distribution 74%/26%/0.7%, and CD4+ T-cell...
Primary lymphomas of the uterine cervix are a rare disease. They often misdiagnosed because their rarity and they can be easily confused with squamous cell carcinoma cervix, as usually presented exophytic mass vaginal bleeding most common symptoms. Nevertheless, considering that both prognosis treatment completely different between them, differential diagnosis should taken into account.A case 51-year-old woman primary diffuse large B-cell lymphoma is presented.Diagnosis this tumor was...