A5029892045- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Bacteriophages and microbial interactions
- Cancer, Hypoxia, and Metabolism
- Nanoparticle-Based Drug Delivery
- Genetic factors in colorectal cancer
- Peptidase Inhibition and Analysis
- Advanced biosensing and bioanalysis techniques
- Colorectal Cancer Treatments and Studies
- PI3K/AKT/mTOR signaling in cancer
- Cancer Mechanisms and Therapy
- Cancer, Lipids, and Metabolism
- Cancer-related Molecular Pathways
- Lymphoma Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Chemokine receptors and signaling
- Virus-based gene therapy research
- RNA modifications and cancer
- Toxin Mechanisms and Immunotoxins
- Supramolecular Self-Assembly in Materials
- Head and Neck Cancer Studies
- CAR-T cell therapy research
Josep Carreras Leukaemia Research Institute
2016-2025
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2016-2025
Hospital de Sant Pau
2016-2025
Instituto de Salud Carlos III
2013-2025
Institut de Recerca Sant Pau
2024-2025
Universitat Autònoma de Barcelona
2004-2024
Fundación Josep Carreras Contra la Leucemia
2021-2022
Institut d'Investigació Biomédica de Bellvitge
2022
Centro de Investigación Biomédica en Red
2012-2019
Biomedical Research Institute
2017-2019
Protein misfolding and deposition underlie an increasing number of debilitating human disorders. We have shown that model proteins unrelated to disease, such as the Src homology 3 (SH3) domain p58α subunit bovine phosphatidyl-inositol-3′-kinase (PI3-SH3), can be converted in vitro into assemblies with structural cytotoxic properties similar those pathological aggregates. By contrast, homologous proteins, α-spectrin-SH3, lack capability forming amyloid fibrils at a measurable rate under any...
PURPOSE: Mutations in the K-ras gene are frequent human cancer. ras activation primary cells results a cellular senescence phenotype that is precluded by inactivation of p16. At clinical level, this may imply differential behavior for tumors with alternative or cooperative function and impairment p16 pathways. PATIENTS AND METHODS: We have determined presence mutations methylation status promoter series 119 prospectively collected colorectal carcinomas. p53 p14 reading frame were also...
Platelet-derived growth factor (PDGF) receptor signaling is a major functional determinant of cancer-associated fibroblasts (CAF). Elevated expression PDGF receptors on stromal CAFs associated with metastasis and poor prognosis, but mechanism(s) that underlie these connections are not understood. Here, we report the identification secreted glycoprotein stanniocalcin-1 (STC1) as mediator by function in setting colorectal cancer. PDGF-stimulated increased migration invasion cocultured cancer...
Colorectal cancer (CRC) has traditionally been treated with genotoxic chemotherapy to activate pro-apoptotic proteins induce anticancer effects. However, cells develop resistance apoptosis, which leads recurrence and poor prognosis. Moreover, this kind of therapy shown be highly toxic healthy tissues and, therefore, patients. To overcome issue, we developed a self-assembly tumor-targeted nanoparticle, T22-DITOX-H6, that incorporates the T22 peptide (a CXCR4 ligand) selectively target...
Cell-targeting peptides or proteins are appealing tools in nanomedicine and innovative medicines because they increase the local drug concentration reduce potential side effects. CXC chemokine receptor 4 (CXCR4) is a cell surface marker associated with several severe human pathologies, including colorectal cancer, for which intracellular targeting agents currently missing.
The fully de novo design of protein building blocks for self-assembling as functional nanoparticles is a challenging task in emerging nanomedicines, which urgently demand novel, versatile, and biologically safe vehicles imaging, drug delivery, gene therapy. While the use viruses virus-like particles limited by severe constraints, generation protein-only nanocarriers progressively reachable engineering protein-protein interactions, resulting blocks. In particular, end-terminal cationic...
Abstract The chemokine receptor CXCR4 has been implicated in the migration and trafficking of malignant B cells several haematological malignancies. Over‐expression identified tumours, but data concerning role this diffuse large cell lymphoma ( DLBCL ) are lacking. is a marker poor prognosis various neoplasms, correlating with metastatic disease decreased survival patients. We studied involvement vitro dissemination vivo. also evaluated prognostic significance 94 biopsies observed that level...
// Miguel Angel Pavón 1, 2, # , Irene Arroyo-Solera Marta Téllez-Gabriel 2 Xavier León 3 David Virós 4 Montserrat López Alberto Gallardo 5 Maria Virtudes Céspedes Isolda Casanova Antonio López-Pousa 6 Antonia Mangues 7 Miquel Quer Agustí Barnadas Ramón 1 Grup d’Oncogènesi i Antitumorals, lnstitut d’Investigacions Biomèdiques Sant Pau (IIB-Sant Pau), Barcelona, Spain Centro de Investigación...
Research Article6 September 2018Open Access Transparent process Selective depletion of metastatic stem cells as therapy for human colorectal cancer María Virtudes Céspedes Institut d'Investigacions Biomèdiques Sant Pau, Hospital de Santa Creu i Barcelona, Spain CIBER Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Search more papers by this author Ugutz Unzueta Anna Aviñó Institute Advanced Chemistry Catalonia (IQAC), CSIC, Alberto Gallardo Department Pathology, la Patricia Álamo...
The impact of cell factory quality control on material properties is a neglected but critical issue in the fabrication protein biomaterials, which are unique merging structure and function. molecular chaperoning conformational status revealed here as potent instructor macroscopic self-assembling, cell-targeted nanoparticles, including biodistribution upon vivo administration. As service to our authors readers, this journal provides supporting information supplied by authors. Such materials...
Abstract Background Current acute myeloid leukemia (AML) therapy fails to eliminate quiescent leukemic blasts in the bone marrow, leading about 50% of patient relapse by increasing AML burden blood, and extramedullar sites. We developed a protein-based nanoparticle conjugated potent antimitotic agent Auristatin E that selectively targets because their CXCR4 receptor overexpression (CXCR4+) as compared normal cells. The therapeutic rationale is based on involvement blast homing quiescence...