A5089952907- Chromosomal and Genetic Variations
- 3D Printing in Biomedical Research
- Bacteriophages and microbial interactions
- Supramolecular Self-Assembly in Materials
- Cellular Mechanics and Interactions
- Multiple Myeloma Research and Treatments
- Biochemical and Structural Characterization
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Polymer Surface Interaction Studies
- RNA and protein synthesis mechanisms
- Bone Tissue Engineering Materials
- Protein purification and stability
- Lipid Membrane Structure and Behavior
- Surfactants and Colloidal Systems
- Silk-based biomaterials and applications
- Probiotics and Fermented Foods
- Spaceflight effects on biology
- Glycosylation and Glycoproteins Research
- Nanoparticle-Based Drug Delivery
- Tribology and Wear Analysis
- Nanofabrication and Lithography Techniques
- Genomics and Phylogenetic Studies
- Force Microscopy Techniques and Applications
- Advanced materials and composites
- Graphene and Nanomaterials Applications
Institut de Ciència de Materials de Barcelona
2013-2022
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2013-2022
University of Plymouth
2020
Centre Technique des Industries Mécaniques
2011
The fully de novo design of protein building blocks for self-assembling as functional nanoparticles is a challenging task in emerging nanomedicines, which urgently demand novel, versatile, and biologically safe vehicles imaging, drug delivery, gene therapy. While the use viruses virus-like particles limited by severe constraints, generation protein-only nanocarriers progressively reachable engineering protein-protein interactions, resulting blocks. In particular, end-terminal cationic...
Cell responses, such as positioning, morphological changes, proliferation, and apoptosis, are the result of complex chemical, topographical, biological stimuli. Here we show macroscopic responses cells when nanoscale profiles made with inclusion bodies (IBs) used for 2D engineering interfaces at microscale. A deep statistical data treatment fibroblasts cultivated on supports patterned green fluorescent protein human basic fibroblast growth factor-derived IBs demonstrates that these...
Abstract Background The cell-surface attachment protein (Env) of the HERV-K(HML-2) lineage endogenous retroviruses is a potentially attractive tumour-associated antigen for anti-cancer immunotherapy. human genome contains around 100 integrated copies (called proviruses or loci) virus and we argue that it important therapy development to know which how many these contribute expression, this varies across tissues. We measured relative provirus expression in HERV-K(HML-2), using enriched...
Quatsome nanovesicles, formed through the self-assembly of cholesterol (CHOL) and cetyltrimethylammonium bromide (CTAB) in water, have shown long-term stability terms size morphology, while at same time exhibiting high CHOL-CTAB intermolecular binding energies. We hypothesize that CHOL/CTAB quatsomes are indeed thermodynamically stable investigate mechanism underlying their formation. A systematic study was performed to determine whether satisfy experimental requisites vesicles. Coarse-grain...
A versatile evaporation-assisted methodology based on the coffee-drop effect is described to deposit nanoparticles surfaces, obtaining for first time patterned gradients of protein (pNPs) by using a simple custom-made device. Fully controllable patterns with specific periodicities consisting stripes different widths and distinct nanoparticle concentration as well can be produced over large areas (∼10 cm2) in fast (up 10 mm2/min), reproducible, cost-effective manner an operational protocol...
Eighty areas with different structural and compositional characteristics made of bacterial inclusion bodies formed by the fibroblast growth factor (FGF-IBs) were simultaneously patterned on a glass surface an evaporation-assisted method that relies coffee-drop effect. The resulting these protein nanoparticles enabled to perform high-throughput study motility NIH-3T3 fibroblasts under conditions including gradient steepness, particle concentrations, area widths FGF-IBs, using for data...