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Amaia Etxebeste

ORCID: 0000-0003-4408-0981
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About
Contact & Profiles
A5073413629
Research Areas
  • Multiple Myeloma Research and Treatments
  • Protein Degradation and Inhibitors
  • Immunotherapy and Immune Responses
  • Peptidase Inhibition and Analysis

Universidad de Navarra
 2023

Centro de Investigación Biomédica en Red de Cáncer
 2023

 Preclinical models for prediction of immunotherapy outcomes and immune evasion mechanisms in genetically heterogeneous multiple myeloma
OPENALEX - Publications 
Marta Larráyoz María J. García‐Barchino Jon Celay Amaia Etxebeste Maddalen Jiménez and 41 more Cristina Pérez Raquel Ordóñez César Cobaleda Cirino Botta Vicente Fresquet Sergio Roa Ibai Goicoechea Catarina Maia Miren Lasaga Marta Chesi P. Leif Bergsagel María José Larráyoz Marı́a José Calasanz Elena Campos-Sánchez Jorge Martínez-Cano Carlos Panizo Paula Rodríguez‐Otero Silvestre Vicent Giovanna Roncador Patricia González Satoru Takahashi Samuel G. Katz Loren D. Walensky Shannon M. Ruppert Elisabeth A. Lasater Maria Amann Teresa Lozano Diana Llópiz Pablo Sarobe Juan José Lasarte Núria Planell David Gómez-Cabrero Olga Kudryashova Anna Kurilovich María V. Revuelta Leandro Cerchietti Xabier Agirre Jesús F. San Miguel Bruno Paiva Felipe Prósper José A. Martínez-Climent

Abstract The historical lack of preclinical models reflecting the genetic heterogeneity multiple myeloma (MM) hampers advance therapeutic discoveries. To circumvent this limitation, we screened mice engineered to carry eight MM lesions (NF-κB, KRAS, MYC, TP53, BCL2, cyclin D1, MMSET/NSD2 and c-MAF) combinatorially activated in B lymphocytes following T cell-driven immunization. Fifteen genetically diverse developed bone marrow (BM) tumors fulfilling pathogenesis. Integrative analyses ∼500...

10.1038/s41591-022-02178-3 article EN cc-by Nature Medicine 2023-03-01
 OAB-033: Pre-clinical models of genetically heterogeneous multiple myeloma reveal mechanisms of immune escape and predict clinical immunotherapy outcomes
OPENALEX - Publications 
Marta Larráyoz María J. García‐Barchino Jon Celay Amaia Etxebeste Maddalen Jimenez and 20 more C. Martin Perez Raquel Ordóñez César Cobaleda Marta Chesi Leif Bergsagel Paula Rodríguez‐Otero Satoru Takahashi Samuel G. Katz Loren D. Walensky Shannon M. Ruppert Elisabeth A. Lasater Maria Amann Juan José Lasarte Anna Kurilovich Leandro Cerchietti Xabier Agirre Jesús F. San Miguel Bruno Paiva Felipe Prósper José A. Martínez-Climent

10.1016/s2152-2650(22)00306-8 article EN Clinical Lymphoma Myeloma & Leukemia 2022-08-01
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