A5037571653- Natural product bioactivities and synthesis
- Metabolomics and Mass Spectrometry Studies
- Ginseng Biological Effects and Applications
- Phytochemistry and Biological Activities
- Traditional Chinese Medicine Analysis
- Biological Activity of Diterpenoids and Biflavonoids
- Plant biochemistry and biosynthesis
- Bioactive Natural Diterpenoids Research
- Plant-derived Lignans Synthesis and Bioactivity
- Advanced Proteomics Techniques and Applications
- Pharmacological Effects of Natural Compounds
- Analytical Chemistry and Chromatography
- Cancer, Lipids, and Metabolism
- Fern and Epiphyte Biology
- Mass Spectrometry Techniques and Applications
- Plant Toxicity and Pharmacological Properties
- Fungal Biology and Applications
- Phytochemical compounds biological activities
- Identification and Quantification in Food
- Gout, Hyperuricemia, Uric Acid
- Plant-based Medicinal Research
- Liver Disease Diagnosis and Treatment
- Phytochemical Studies and Bioactivities
- Essential Oils and Antimicrobial Activity
- Meat and Animal Product Quality
Beijing University of Chinese Medicine
2011-2025
Shenyang Pharmaceutical University
2015
National Institutes for Food and Drug Control
2003-2014
United States Food and Drug Administration
2005-2013
Macau University of Science and Technology
2012
Northwest University
2010-2011
National Taiwan Normal University
2010
National Medical Products Administration
2004-2005
University of Mississippi
2004-2005
Chinese University of Hong Kong
2004
Chronic kidney disease (CKD) is becoming a worldwide public health problem. In this study, metabonomics method based on the ultra performance liquid chromatography/high-sensitivity mass spectrometry with MS(E) data collection technique was undertaken to explore excretion pattern of low molecular metabolites in rat model adenine-induced chronic renal failure (CRF). Coupled blood biochemistry and histopathology results, significant difference metabolic profiling between CRF group control by...
The surface layer of Poria cocos (Fu-Ling-Pi, FLP) is commonly used in traditional Chinese medicine and its diuretic effect was confirmed rat. Ultra performance liquid chromatography/quadrupole time-of-flight high-sensitivity mass spectrometry a novel spectrometryElevated Energy data collection technique employed to investigate metabonomic characteristics chronic kidney disease (CKD) induced from adenine excess the protective effects FLP. Multiple metabolites are detected CKD correlated with...
Amentoflavone and three other flavonoids were isolated from the ethanol extract of Selaginella sinensis. showed potent antiviral activity against respiratory syncytial virus (RSV), with an IC50 5.5 μg/ml. The contents amentoflavone in nine species determined by reversed-phase HPLC. S. sinensis a higher content 1.13%.
An ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC Q-TOF MS) metabonomics approach was employed to study the serum metabolic profiling of adenine-induced chronic renal failure (CRF) rats. Acquired data were subjected principal component analysis (PCA) for differentiating CRF and normal control groups. Potential biomarkers screened by using S-plot identified accurate mass, isotopic pattern MS/MS fragments information obtained from UPLC MS...
The ethnic drug Melastoma dodecandrum Lour. (MDL) is widely distributed throughout South China, and the major component of Gong Yan Ping Tablets/Capsules Zi Di Ning Xue San. Although pharmacological effects MDL have been well documented, its chemical profile has not fully determined. In this study, we developed a rapid sensitive UPLC-ESI-Q-Exactive Focus-MS/MS method to characterize constituents in positive negative ionization modes. A comparison chromatographic spectrometric data obtained...
Chronic renal failure (CRF) is a major challenge for the public healthcare problem. A novel UPLC Q-TOF/MS method with MSE data collection mode was developed as very effective biochemical analytical tool precise identification of important biomarkers in adenine-induced CRF rats. Nine endogenous metabolites were identified by using metabonomic combined multivariate analysis, accurate mass, isotopic pattern, fragments information and MassLynx i-FIT algorithm. The indicated perturbations bile...
Mountain-cultivated ginseng (MCG) and cultivated (CG) both belong to Panax have similar ingredients. However, their pharmacological activities are different due significantly growth environments. An ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS/MS)-based approach was developed distinguish MCG CG. Multivariate statistical methods, such as principal component analysis supervised orthogonal partial-least-squares discrimination were used select...
ABSTRACT Introduction We report a rapid and accurate method to determine the natural occurrence of aflatoxins (AFs) B1, B2, G1 G2 in medicinal herbs analysis 174 commercial samples by this method. Objective The aim present work is examine common herbs. Methodology AFs were extracted, purified immunoaffinity column analysed high‐performance liquid chromatography–tandem quadrupole mass spectrometry with electrospray ionisation (HPLC–MS/MS). Results can be separated within 6 min using an...